Developing the analytical model of a multibody system is often the initial step in control and optimization. The analytical model (equations of motion) describes a system’s time evolution under specified forcing conditions. Although developing...
SuFEx chemistry is based on the unique reactivity of the sulfonyl fluoride group with a range of nucleophiles. Accordingly, sulfonyl fluorides label multiple nucleophilic amino acid residues, making these reagents popular in both chemical biology and...
In advance of building moored floating offshore platforms, in recent years, there has been a greater demand for two-way coupled simulations between a motion solver based on the viscous flow theory and a mooring line model, including cable dynamics. T...
Synthetic DNA barcodes are double-stranded DNA molecules designed to carry recoverable information, information that can be used to represent and track objects and organisms. DNA barcodes offer robust, sensitive detection using standard amplification...
Mathematical optimization is a widespread method in order to improve, for instance, the efficiency of energy systems. A simulation approach based on partial differential equations can typically not be formulated as an optimization problem, thus requi...
Blockchain-based decentralized cryptocurrency platforms are currently one of the hottest topics in technology. Although most of the interest is generated by cryptocurrency related activities, it is becoming apparent that a much wider spectrum of appl...
Experimental pEC50s for 216 selective respiratory syncytial virus (RSV) inhibitors are used to develop classification models as a potential screening tool for a large library of target compounds. Variable selection algorithm coupled with random fores...
Heteroaromatic motifs are prevalent in natural products and numerous high-value drug molecules. Consequently, the construction of alkylated heterocyclic frameworks holds significant importance. The Minisci reaction of heteroarenes has evolved into a...
Background/Objectives: Routine diagnostic microbiology relies on separate workflows for pathogen identification, resistance genotyping, and molecular surveillance. This proof-of-concept study evaluated the feasibility of consolidating targeted assays...
Over the past years, large language models (LLMs) have gained significant attention and have led to major breakthroughs in natural language processing (NLP). Despite their remarkable efficiency and contextual understanding, LLMs still remain limited...
Single-cell genomics offers novel insights into genomic heterogeneity within cell populations, reframing our understanding of human development, tumorigenesis, and aging. However, constrained by the picogram-scale DNA templates of individual cells, W...
Background: The edible gonads of the sea urchin Paracentrotus lividus are highly valued, yet sex cannot be determined externally, limiting selective harvest and quality control. Objective: We aimed to test whether headspace solid-phase microextractio...
Background: The emergence of multidrug-resistant bacteria, coupled with the stagnation of antibiotic discovery, underscores the urgent need for new therapeutic strategies targeting underexplored bacterial mechanisms. The Escherichia coli mechanosensi...