Organic Chalcogen Chemistry: Recent Advances

Dear Colleagues,

Chalcogens (S, Se, Te) are relevant elements with multiple oxidation states and can be stereogenic centers, which contribute to the astounding diversity and complexity of molecule construction. Chalcogen atom-containing organic compounds are abundant in natural products, materials, agrochemicals and blockbuster pharmaceuticals. Chalcogens also show potential for creating novel polymers with improved mechanical, optical and electrochemical properties. Chalcogen-containing compounds are also important synthetic intermediates and can serve as versatile building blocks, catalysts and auxiliaries for organic transformations, including redox functional group interconversions. In this context, achieving high chemo-, regio- and stereoselectivity with cheaper, less toxic catalysts, milder reaction conditions, more readily available starting materials and a broader substrate scope remains a key objective in designing synthetic strategies for chalcogen-containing compounds. Reducing expensive and hazardous redox reagents and enabling more sustainable and greener routes, photochemistry and electrochemistry offer opportunities to develop new methodologies to synthesize chalcogen organic compounds. Scholars in theoretical chemistry, crystallography and supramolecular chemistry are making significant efforts to study chalcogen bonding, a subclass of noncovalent interactions. Organochalcogen biomolecules attract significant attention because of the presence of cysteines and selenocysteines in human protein families. Incorporating chalcogen atoms into biomolecules, such as nucleosides, is a promising strategy for developing therapeutics.

This Special Issue highlights the significance of chalcogen-containing compounds across various fields, including but not limited to the above-mentioned topics. Both original research articles and comprehensive review papers are welcome.

Dr. Damiano Tanini
Guest Editor

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• sulfur
• selenium
• tellurium
• synthetic methodologies
• redox chemistry
• medicinal chemistry
• biological activities
• catalysis
• sustainable chemistry