You are currently on the new version of our website. Access the old version .

1,867 Results Found

  • Article
  • Open Access
16 Citations
5,041 Views
13 Pages

Could Road Safety Education (RSE) Help Parents Protect Children? Examining Their Driving Crashes with Children on Board

  • Francisco Alonso,
  • Sergio A. Useche,
  • Eliseo Valle,
  • Cristina Esteban and
  • Javier Gene-Morales

Recent evidence suggests that driving behavior and traffic safety outcomes of parents may be influenced by the extent to which they receive information and education on road safety, as well as the fact of driving with their children on board, which m...

  • Article
  • Open Access
7 Citations
2,720 Views
12 Pages

Background: Children with intellectual disability (ID) are known to have a deficit in self-care, social interaction, and learning abilities. Families raising these children experience a range of difficulties that require supportive systems to meet th...

  • Article
  • Open Access
3,751 Views
18 Pages

15 September 2025

Research in western countries concludes that children and adolescents are exposed to multiple forms of online risks and harms. However, in the context of Saudi Arabia, research in online safety education is lagging. Currently, online safety education...

  • Article
  • Open Access
4 Citations
10,157 Views
11 Pages

Relative Safety Assessment for Positioning Children in Vehicles with Varying Levels of Advanced Safety Technologies

  • Praveena Penmetsa,
  • Emmanuel K. Adanu,
  • Abhay Lidbe,
  • Xiaobing Li,
  • Shashi Nambisan and
  • Steven L. Jones

Recent studies suggest that advances in rear seat occupant protection are trailing while frontal crash prevention technologies have disproportionately improved front seat occupant safety. Therefore, the first objective of this study is to identify th...

  • Article
  • Open Access
5 Citations
2,668 Views
12 Pages

Safety Messaging Boosts Parental Vaccination Intention for Children Ages 5–11

  • Zhihan Cui,
  • Lu Liu,
  • Dan Li,
  • Sherry Jueyu Wu and
  • Xinyue Zhai

28 July 2022

The COVID-19 vaccination rate among children ages 5–11 is low in the U.S., with parental vaccine hesitancy being the primary cause. Current work suggests that safety and side effect concerns are the primary reasons for such vaccine hesitancy. T...

  • Article
  • Open Access
222 Views
12 Pages

Safety of Children with Food Allergies in Public Schools: Gaps, Challenges, and Strategies for Improvement

  • Alexandra Ribeiro,
  • Sara Diogo Gonçalves,
  • Maria Monteiro and
  • Ana Caramelo

19 December 2025

Food allergies in school-aged children are a growing public health concern, requiring coordinated strategies to ensure safety in educational settings. This study aimed to evaluate the safety conditions for children and young people with food allergie...

  • Article
  • Open Access
18 Citations
5,233 Views
17 Pages

Background: Education in road safety (also known as Road Safety Education—RSE) constitutes, nowadays, an emergent approach for improving present and future road behaviors, aiming at taking action against the current, and concerning, state-of-af...

  • Systematic Review
  • Open Access
56 Citations
9,955 Views
29 Pages

The literature on children’s active transportation has shown the influence of the built environment characteristics on walking and crashes. Various reviews have examined those two questions. One influence on walking is the perception of traffic...

  • Article
  • Open Access
24 Citations
15,670 Views
16 Pages

19 August 2023

This study analyzes the previous literature on the online safety of children and youth under “the 4Cs risk framework” concerning contact, content, conduct, and contract risks. It then conducts a comparative study of Australia, Canada, and...

  • Article
  • Open Access
5 Citations
3,621 Views
12 Pages

Food Safety Practices and Stunting among School-Age Children—An Observational Study Finding from an Urban Slum of Bangladesh

  • Kazi Istiaque Sanin,
  • Ahshanul Haque,
  • Baitun Nahar,
  • Mustafa Mahfuz,
  • Mansura Khanam and
  • Tahmeed Ahmed

Background: Food safety incorporates the handling, preparation, and storage of food materials in ways that prevent foodborne illness. We aimed to investigate the typical food safety practices in a Bangladeshi slum context and to explore if stunting a...

  • Feature Paper
  • Review
  • Open Access
47 Citations
11,414 Views
21 Pages

Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents

  • Derrick Matthew Buchanan,
  • Thomas Bogdanowicz,
  • Neha Khanna,
  • Guillaume Lockman-Dufour,
  • Philippe Robaey and
  • Amedeo D’Angiulli

10 February 2021

Background: Transcranial direct current stimulation (tDCS) is a safe, tolerable, and acceptable technique in adults. However, there is limited evidence for its safety in youth. Although limited, there are a handful of important empirical articles tha...

  • Article
  • Open Access
70 Citations
9,290 Views
14 Pages

Background: Road Safety Education (RSE) is widely known as a reliable determinant of the future results for what concerns health and welfare and as an undisputable factor which contributes to the social behavior of individuals and to their mid- and l...

  • Commentary
  • Open Access
3 Citations
5,021 Views
8 Pages

This paper discusses school safety mainly in relation to safety education and examines measures for the comprehensive development of systems to ensure the safety of children at school, including those requiring medical care. The number of children re...

  • Systematic Review
  • Open Access
23 Citations
5,059 Views
10 Pages

10 March 2022

Background: The proportion of children and adolescents with COVID-19 had gradually increased according to data reported by WHO. However, there was no meta-analysis of effectiveness and safety of SARS-CoV-2 vaccines in children and adolescents. We aim...

  • Review
  • Open Access
21 Citations
8,742 Views
13 Pages

31 December 2019

The growing number of available vaccines that can be potentially co-administered makes the assessment of the safety of vaccine co-administration increasingly relevant but complex. We aimed to synthesize the available scientific evidence on the safety...

  • Article
  • Open Access
3 Citations
3,843 Views
14 Pages

Efficacy and Safety of Statin Treatment in Children with Familial Hypercholesterolemia: Outcomes of 20 Years of Experience

  • Radosław Motkowski,
  • Paweł Abramowicz,
  • Jolanta Kubalska,
  • Bożena Mikołuć and
  • Jerzy Konstantynowicz

21 November 2023

Background: The objective of this retrospective cohort study was to present the experience of 20-year-long comprehensive care of pediatric patients with familial hypercholesterolemia (FH) in a single academic center. Methods and Results: The study in...

  • Article
  • Open Access
19 Citations
3,762 Views
11 Pages

Long-Term Safety of Omalizumab in Children with Asthma and/or Chronic Spontaneous Urticaria: A 4-Year Prospective Study in Real Life

  • Francesca Galletta,
  • Lucia Caminiti,
  • Cecilia Lugarà,
  • Simone Foti Randazzese,
  • Paolo Barraco,
  • Federica D’Amico,
  • Pierangela Irrera,
  • Giuseppe Crisafulli and
  • Sara Manti

29 June 2023

Background: Insufficient data are available on the long-term “real-life” safety profile of omalizumab in children. This study evaluated the long-term safety of omalizumab in a pediatric cohort with severe asthma or chronic spontaneous urt...

  • Article
  • Open Access
6 Citations
2,687 Views
14 Pages

Safety Surveillance of Mass Praziquantel and Albendazole Co-Administration in School Children from Southern Ethiopia: An Active Cohort Event Monitoring

  • Tigist Dires Gebreyesus,
  • Eyasu Makonnen,
  • Tafesse Tadele,
  • Habtamu Gashaw,
  • Workagegnew Degefe,
  • Heran Gerba,
  • Birkneh Tilahun Tadesse,
  • Parthasarathi Gurumurthy and
  • Eleni Aklillu

26 October 2022

Preventive chemotherapy (PC) with praziquantel and albendazole co-administration to all at-risk populations is the global intervention strategy to eliminate schistosomiasis and soil-transmitted helminth (STH) from being public health problems. Due to...

  • Article
  • Open Access
1,425 Views
17 Pages

28 July 2025

As digital technologies and food environments evolve, ensuring children’s food safety has become a pressing public health priority. This study examines how the policy discourse on children’s dietary safety in Korea has shifted over time b...

  • Article
  • Open Access
13 Citations
3,563 Views
13 Pages

Safety Monitoring of mRNA COVID-19 Vaccines in Children Aged 5 to 11 Years by Using EudraVigilance Pharmacovigilance Database: The CoVaxChild Study

  • Alessia Zinzi,
  • Mario Gaio,
  • Valerio Liguori,
  • Rosanna Ruggiero,
  • Marina Tesorone,
  • Francesco Rossi,
  • Concetta Rafaniello and
  • Annalisa Capuano

9 February 2023

Although the safety profiles of mRNA COVID-19 vaccines (mRNA-1273 and BNT162b2) were evaluated in pre-authorization clinical trials, real-world data allow us to better define their benefit/risk ratio in the paediatric population. The current study ai...

  • Article
  • Open Access
15 Citations
10,640 Views
19 Pages

8 September 2021

Hyponatraemia is a known complication in hospitalised children receiving maintenance intravenous fluid. Several studies have been published to investigate the efficacy and safety of intravenous fluids in children. However, there is still an ongoing d...

  • Article
  • Open Access
3 Citations
3,913 Views
18 Pages

The Safety and Immunogenicity of a Quadrivalent Influenza Subunit Vaccine in Healthy Children Aged 6–35 Months: A Randomized, Blinded and Positive-Controlled Phase III Clinical Trial

  • Lili Huang,
  • Guangfu Li,
  • Yuhui Zhang,
  • Xue Zhao,
  • Kai Wang,
  • Chunyu Jia,
  • Wei Zhang,
  • Jiebing Tan,
  • Xiaofen Chen and
  • Yaodong Zhang
  • + 6 authors

26 April 2025

Background: Influenza is a serious contagious disease caused by influenza virus. It is particularly dangerous for children, potentially leading to severe and even fatal complications. The aim of this study was to evaluate the safety and immunogenicit...

  • Article
  • Open Access
21 Citations
5,050 Views
19 Pages

(1) Background: In the context of a children friendly city, accessibility and safety are the basic needs of children’s pedestrian school travel. This study proposes a comprehensive evaluation method of pedestrian accessibility and safety for ch...

  • Article
  • Open Access
3 Citations
2,471 Views
23 Pages

30 June 2023

The disparity between urban and rural development in China has resulted in the significant migration of rural laborers to urban areas, giving rise to a growing population of left-behind children in rural areas. The number of accidental injuries among...

  • Article
  • Open Access
328 Views
12 Pages

Safety Evaluation of Large-Scale Administration of a Novel Human Diploid (SV-1) Cell Line-Derived Varicella Attenuated Live Vaccine in Children 7–12 Years Old

  • Yuanyuan Zhu,
  • Yurong Li,
  • Jing Yu,
  • Borong Xu,
  • Xun Li,
  • Ran Hu,
  • Xiaozhe Song,
  • Yonghong Sun,
  • Dongsheng Liu and
  • Zhiguo Wang
  • + 1 author

23 December 2025

Objectives: Varicella is a highly contagious viral disease affecting children. The SV-1 cell line-based varicella attenuated live vaccine (SV-1VarV) is the first vaccine produced using the human diploid SV-1 cell substrate. This study evaluated the r...

  • Article
  • Open Access
19 Citations
11,306 Views
16 Pages

Child Sexual Assault (CSA) in Aboriginal and Torres Strait Islander communities is a complex issue that cannot be understood in isolation from the ongoing impacts of colonial invasion, genocide, assimilation, institutionalised racism and severe socio...

  • Article
  • Open Access
9 Citations
4,385 Views
11 Pages

Immunogenicity and Safety of a Newly Developed Live Attenuated Varicella Vaccine in Healthy Children: A Multi-National, Randomized, Double-Blinded, Active-Controlled, Phase 3 Study

  • Ui Yoon Choi,
  • Ki Hwan Kim,
  • Hye-Kyung Cho,
  • Dong Ho Kim,
  • Sang Hyuk Ma,
  • Young Youn Choi,
  • Chun Soo Kim,
  • Maria Rosario Capeding,
  • Ilya Angelica Rochin Kobashi and
  • Jong-Hyun Kim
  • + 3 authors

24 August 2023

Korean manufacturers have developed a new varicella vaccine, NBP608. This phase 3, randomized, double-blind, multicenter study aimed to compare the immunogenicity and safety of NBP608 in healthy children to those of VarivaxTM (control). Children aged...

  • Article
  • Open Access
2 Citations
4,451 Views
9 Pages

Transportation-related injuries are a leading cause of pediatric death, and effective interventions are limited. Otto the Auto is a website offering engaging, interactive activities. We evaluated Otto among a sample of sixty-nine 4- and 5-year-old ch...

  • Article
  • Open Access
10 Citations
6,593 Views
11 Pages

There is a worldwide concern for young children’s online safety and a growing necessity for e-safety skills to be taught to children from a young age as part of formal schooling. The purpose of this study was to design and evaluate the effectiv...

  • Article
  • Open Access
22 Citations
3,672 Views
13 Pages

This cross-sectional study examines built and natural environmental correlates of parental safety concerns for children’s active travel to school (ATS), controlling for socio-demographic, attitudinal, and social factors. Questionnaire surveys (...

  • Article
  • Open Access
2,097 Views
11 Pages

Safety and Immunogenicity of the Tetravalent Recombinant COVID-19 Protein Vaccine SCTV01E in Children and Adolescents Aged 3 to 17 Years: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial

  • Fengcai Zhu,
  • Ting Huang,
  • Pengfei Jin,
  • Linglin Zhang,
  • Zhongqiang Jin,
  • Wenli Zhang,
  • Dongya Yuan,
  • Zhong Wang,
  • Yusong Deng and
  • Liangzhi Xie
  • + 5 authors

7 January 2025

Background: SCTV01E is a tetravalent recombinant COVID-19 vaccine authorized for emergency use in China for adults 18 years and older but not for those under 18. Objective: This Phase 2 trial assessed the safety and immunogenicity of SCTV01E in healt...

  • Perspective
  • Open Access
4,540 Views
21 Pages

Apmerengentyele—Our Systems, Our Children, Our Safety, Our Wellbeing

  • William Tilmouth,
  • Veronica Doolan,
  • Jane Vadiveloo and
  • Jen Lorains

9 September 2025

Western systems of child protection cannot protect First Nations children. Australia’s current child protection systems were born from a legislated and explicit intention of destroying the culture, language and identity of First Nations childre...

  • Article
  • Open Access
6 Citations
4,732 Views
11 Pages

The Current Status of Public Playground Safety and Children’s Risk Taking Behavior in the Park: Nakhon Si Thammarat Province, Thailand

  • Preeda Sansakorn,
  • Uraiwan Madardam,
  • Jutaluck Pongsricharoen,
  • Narumon Srithep,
  • Nisarat Janjamsri and
  • Jittaporn Mongkonkansai

12 July 2022

The playground is perhaps the one area where school children feel like they can roam free, and public playgrounds provide many learning opportunities through different types of play. A cross-sectional descriptive study is presented with the objective...

  • Article
  • Open Access
8 Citations
3,392 Views
18 Pages

Health Safety Assessment of Ready-to-Eat Products Consumed by Children Aged 0.5–3 Years on the Polish Market

  • Anita Żmudzińska,
  • Anna Puścion-Jakubik,
  • Joanna Bielecka,
  • Monika Grabia,
  • Jolanta Soroczyńska,
  • Konrad Mielcarek and
  • Katarzyna Socha

1 June 2022

Toxic elements have a negative impact on health, especially among infants and young children. Even low levels of exposure can impair the normal growth and development of children. In young children, all organs and metabolic processes are insufficient...

  • Article
  • Open Access
3,669 Views
25 Pages

Children Wearing Bicycle Helmets Influenced by Their Parents’ Safety Perception as Adults and Children

  • Leena R. Baghdadi,
  • Razan A. Alotaibi,
  • Layan A. Aldoukhi,
  • Wafa M. Alqahtani,
  • Roaa A. Alharbi and
  • Alhnouf H. Alyami

11 February 2025

Purpose: Cycling is a popular activity for children aged 5–14 years and has a notable risk of head injuries. Extensive evidence shows that bicycle helmets can reduce the severity of head injuries and prevent fatalities. The current study examin...

  • Article
  • Open Access
2 Citations
5,453 Views
12 Pages

Safety of Immunization for Children with Immune Thrombocytopenia

  • Xiangshi Wang,
  • Tianxing Feng,
  • Chuning Wang,
  • Jingjing Li,
  • Yanling Ge,
  • Xiaowen Zhai,
  • Hongsheng Wang and
  • Mei Zeng

9 January 2024

Vaccine hesitancy is a common issue for children with immune thrombocytopenia (ITP) in China. The objective of this paper is to assess the immunization statuses of children with ITP, analyze the possible relationship between immunization and thromboc...

  • Article
  • Open Access
20 Citations
9,750 Views
15 Pages

Child Pedestrian Safety: Study of Street-Crossing Behaviour of Primary School Children with Adult Supervision

  • Malik Sarmad Riaz,
  • Ariane Cuenen,
  • Evelien Polders,
  • Muhammad Bilal Akram,
  • Moustafa Houda,
  • Davy Janssens and
  • Marc Azab

27 January 2022

Road traffic accidents are the primary cause of injuries and fatalities among children. The current study focuses on children’s (un)safe crossing behaviour in a real traffic situation accompanied by an adult at a crosswalk in front of their sch...

  • Systematic Review
  • Open Access
2 Citations
3,635 Views
18 Pages

Efficacy and Safety of Acupuncture and Related Techniques in the Management of Oncological Children and Adolescent Patients: A Systematic Review

  • Esther Martínez García,
  • M. Betina Nishishinya Aquino,
  • Ofelia Cruz Martínez,
  • Yiming Ren,
  • Ruyu Xia,
  • Yutong Fei and
  • Carles Fernández-Jané

19 September 2024

Background/Objectives: Oncology acupuncture is emerging as a complementary treatment in pediatric cancer care centers. It is valued for its potential to manage symptoms associated with cancer and treatment toxicities without increasing polypharmacy....

  • Article
  • Open Access
27 Citations
4,970 Views
14 Pages

Safety and Immunogenicity of a Shigella Bivalent Conjugate Vaccine (ZF0901) in 3-Month- to 5-Year-Old Children in China

  • Yi Mo,
  • Wenjian Fang,
  • Hong Li,
  • Junji Chen,
  • Xiaohua Hu,
  • Bin Wang,
  • Zhengli Feng,
  • Honghua Shi,
  • Ying He and
  • Lin Du
  • + 2 authors

28 December 2021

No licensed Shigella vaccine is presently available globally. A double-blinded, randomized, placebo-controlled, age descending phase II clinical trial of a bivalent conjugate vaccine was studied in China. The vaccine ZF0901 consisted of O-specific po...

  • Article
  • Open Access
20 Citations
6,227 Views
22 Pages

Evaluating a Website to Teach Children Safety with Dogs: A Randomized Controlled Trial

  • David C. Schwebel,
  • Peng Li,
  • Leslie A. McClure and
  • Joan Severson

Dog bites represent a significant threat to child health. Theory-driven interventions scalable for broad dissemination are sparse. A website was developed to teach children dog safety via increased knowledge, improved cognitive skills in relevant dom...

  • Article
  • Open Access
5 Citations
2,984 Views
12 Pages

12 October 2023

Two doses of the inactivated influenza vaccine (IIV) are generally recommended for children under 9 years old. This study assessed the necessity for a second dose of quadrivalent IIV (IIV4) in children aged 3–8 years. In this randomized, open-l...

  • Article
  • Open Access
7 Citations
5,513 Views
20 Pages

Design and Development of an Instrument on Knowledge of Food Safety, Practices, and Risk Perception Addressed to Children and Adolescents from Low-Income Families

  • Sueny Andrade Batista,
  • Elke Stedefeldt,
  • Eduardo Yoshio Nakano,
  • Mariana de Oliveira Cortes,
  • Raquel Braz Assunção Botelho,
  • Renata Puppin Zandonadi,
  • António Raposo,
  • Heesup Han and
  • Verônica Cortez Ginani

20 February 2021

In the fight against foodborne diseases, expanding access to information for different groups is needed. In this aspect, it is crucial to evaluate the target audience’s particularities. This study constructed and validated an instrument containing th...

  • Article
  • Open Access
4 Citations
1,188 Views
7 Pages

An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery

  • Lina Kalibatienė,
  • Vytenis Kalibatas,
  • Andrius Macas and
  • Darius Trepenaitis

12 May 2015

Objective: The aim of this study was to evaluate the effectiveness and safety of oral midazolam in children undergoing dental surgery. Materials and methods: A prospective, randomized, controlled trial was conducted to assess the effectiveness and s...

  • Systematic Review
  • Open Access
65 Citations
13,828 Views
13 Pages

Safety, Immunogenicity, and Efficacy of COVID-19 Vaccines in Children and Adolescents: A Systematic Review

  • Meng Lv,
  • Xufei Luo,
  • Quan Shen,
  • Ruobing Lei,
  • Xiao Liu,
  • Enmei Liu,
  • Qiu Li and
  • Yaolong Chen

29 September 2021

Aim: To identify the safety, immunogenicity, and protective efficacy of COVID-19 vaccines in children and adolescents. Methods: We conducted a systematic review of published studies and ongoing clinical studies related to the safety, immunogenicity,...

  • Article
  • Open Access
1,142 Views
14 Pages

Safety and Immunogenicity of Vaccines in Children with Kaposiform Hemangioendothelioma Receiving Sirolimus: A Prospective Study

  • Junhong Yuan,
  • Zhenxiang Yuan,
  • Yingjing Ding,
  • Zuopeng Wang,
  • Wei Yao,
  • Jingjing Li,
  • Mei Zeng and
  • Kai Li

26 August 2025

Background: Sirolimus is an effective treatment for kaposiform hemangioendothelioma (KHE), a rare vascular tumor in children. However, its immunosuppressive properties raise concerns regarding the safety and efficacy of vaccinations during treatment....

  • Article
  • Open Access
5 Citations
3,057 Views
19 Pages

Vaccinating Children against SARS-CoV-2: A Literature Review and Survey of International Experts to Assess Safety, Efficacy and Perceptions of Vaccine Use in Children

  • Lauren Hookham,
  • Hillary C. Lee,
  • Divya A. Patel,
  • Mariana Coelho,
  • Norberto Giglio,
  • Kirsty Le Doare and
  • Pia S. Pannaraj

29 December 2022

Introduction: The balance of risks and benefits of COVID-19 vaccination in children is more complex than in adults with limited paediatric data resulting in no global consensus on whether all healthy children should be vaccinated. We sought to assess...

  • Article
  • Open Access
18 Citations
7,589 Views
17 Pages

This article presents the issues and needs for modern solutions in building urban infrastructure, based on the smart city idea to improve the living standards of residents. Particular attention is paid to one of the most important aspects of life, re...

  • Article
  • Open Access
4 Citations
3,159 Views
11 Pages

Mental Health and Well-Being among Children of Public Safety Personnel in Canada

  • Andrea M. Stelnicki,
  • Laleh Jamshidi,
  • Tamara L. Taillieu,
  • R. Nicholas Carleton and
  • Tracie O. Afifi

Public safety personnel (PSP) often experience stress due to their occupational demands that affect the family environment (e.g., work-family conflict, marital breakdown, disruption to home routines, and holidays). A substantial base of research has...

  • Review
  • Open Access
7 Citations
3,923 Views
15 Pages

Efficacy and Safety of Continuous Infusion of Vancomycin in Children: A Systematic Review

  • Marta Alonso-Moreno,
  • Marta Mejías-Trueba,
  • Laura Herrera-Hidalgo,
  • Walter Alfredo Goycochea-Valdivia and
  • María Victoria Gil-Navarro

Vancomycin is used to treat a wide variety of infections within the pediatric population. In adults, continuous infusion of vancomycin (CIV) has been evaluated as an alternative to intermittent infusion of vancomycin (IIV) with potential advantages....

  • Communication
  • Open Access
15 Citations
3,347 Views
6 Pages

Safety of Monoclonal Antibodies in Children Affected by SARS-CoV-2 Infection

  • Lorenza Romani,
  • Francesca Ippolita Calò Carducci,
  • Sara Chiurchiù,
  • Laura Cursi,
  • Maia De Luca,
  • Martina Di Giuseppe,
  • Andrzej Krzysztofiak,
  • Laura Lancella,
  • Paolo Palma and
  • Stefania Bernardi
  • + 4 authors

Monoclonal antibody therapies for COVID-19 have been frequently used in adults, whereas there are little data regarding the safety or efficacy of monoclonal antibody treatments in pediatric patients affected by COVID-19. We report our experience in t...

of 38