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  • Article
  • Open Access
37 Citations
10,252 Views
24 Pages

Alpha-Bulges in G Protein-Coupled Receptors

  • Rob Van der Kant and
  • Gert Vriend

6 May 2014

Agonist binding is related to a series of motions in G protein-coupled receptors (GPCRs) that result in the separation of transmembrane helices III and VI at their cytosolic ends and subsequent G protein binding. A large number of smaller motions als...

  • Article
  • Open Access
506 Views
27 Pages

Boxy/Peanut Bulges: Comparative Analysis of EGIPS Galaxies and TNG50 Models

  • Anton Smirnov,
  • Alexander Marchuk,
  • Viktor Zozulia,
  • Natalia Sotnikova and
  • Sergey Savchenko

13 January 2026

We investigated the properties of boxy/peanut-shaped (B/PS) bulges in a sample of 71 galaxies from the Edge-on Galaxies in the Pan-STARRS Survey (EGIPS) and 20 simulated galaxies from Illustris TNG50 using multicomponent photometric decomposition. Fo...

  • Article
  • Open Access
10 Citations
4,138 Views
18 Pages

A Study on the Vortex Induced Vibration of a Cylindrical Structure with Surface Bulges

  • Haoyuan Xu,
  • Jie Wang,
  • Zhiqing Li,
  • Kaihua Liu,
  • Jiawei Yu and
  • Bo Zhou

19 November 2022

Inspired by the cactus in nature, a cactus-like cross-sectional structure was proposed to achieve the VIV suppression. The VIV of the elastically mounted cylinder was realized based on the ANSYS Fluent and User Defined Function (UDF). The dynamic mot...

  • Article
  • Open Access
1 Citations
909 Views
23 Pages

12 February 2025

The tubercles on the flipper of humpback whales are beneficial for improving their locomotion performance. Based on biomimetic design, the bulge model was developed to mimic this function through cubic B-spline curve fitting, aiming to improve the st...

  • Article
  • Open Access
5 Citations
2,846 Views
15 Pages

Knotify+: Toward the Prediction of RNA H-Type Pseudoknots, Including Bulges and Internal Loops

  • Evangelos Makris,
  • Angelos Kolaitis,
  • Christos Andrikos,
  • Vrettos Moulos,
  • Panayiotis Tsanakas and
  • Christos Pavlatos

6 February 2023

The accurate “base pairing” in RNA molecules, which leads to the prediction of RNA secondary structures, is crucial in order to explain unknown biological operations. Recently, COVID-19, a widespread disease, has caused many deaths, affec...

  • Article
  • Open Access
19 Citations
5,729 Views
12 Pages

The Habitability of the Galactic Bulge

  • Amedeo Balbi,
  • Maryam Hami and
  • Andjelka Kovačević

3 August 2020

We present a new investigation of the habitability of the Milky Way bulge, that expands previous studies on the Galactic Habitable Zone. We discuss existing knowledge on the abundance of planets in the bulge, metallicity and the possible frequency of...

  • Article
  • Open Access
1 Citations
2,154 Views
13 Pages

Zinc N,N-bis(2-picolyl)amine Chelates Show Substitution-Dependent Cleavage of Phosphodiesters in Models as Well as of PNAzyme-RNA Bulges

  • Søren W. Svenningsen,
  • Olivia Luige,
  • Zeyed Abdulkarim,
  • Roger Strömberg and
  • Nicholas H. Williams

PNAzymes are a group of artificial enzymes which show promising results in selective and efficient cleavage of RNA targets. In the present study, we introduce a series of metal chelating groups based on N,N-bis(2-picolyl) groups (parent, 6-methyl and...

  • Article
  • Open Access
5 Citations
1,841 Views
25 Pages

The Rotation of Classical Bulges in Barred Galaxies in the Presence of Gas

  • Rubens E. G. Machado,
  • Kenzo R. Sakamoto,
  • Andressa Wille and
  • Gustavo F. Gonçalves

Barred galaxies often develop a box/peanut pseudobulge, but they can also host a nearly spherical classical bulge, which is known to gain rotation due to the bar. We aim to explore how the presence of gas impacts the rotation of classical bulges. We...

  • Article
  • Open Access
5 Citations
6,023 Views
18 Pages

14 February 2019

The bulge deformation of the continuous casting slab must be controlled in order to improve the slab quality. In this study, a coupled three-dimensional thermomechanical model is suggested based on dynamic contact between the slab and the rollers, so...

  • Case Report
  • Open Access
1 Citations
153 Views
3 Pages

Bulging Fontanel During a Measles Infection

  • Kübra Şahin,
  • Gülsüm İclal Bayhan and
  • Başak Alan

28 December 2020

Introduction: Causes of a bulging fontanel in children include viral/bacterial meningitis, encephalitis, hydrocephaly, intracranial bleeding, psedotumor cerebri and central nervous system tumors. A less well-known cause of acutely-developing fontanel...

  • Article
  • Open Access
18 Citations
5,098 Views
16 Pages

Experimental and Numerical Simulation Investigation on Laser Flexible Shock Micro-Bulging

  • Huixia Liu,
  • Xianqing Sun,
  • Zongbao Shen,
  • Liyin Li,
  • Chaofei Sha,
  • Youjuan Ma,
  • Jenn-Terng Gau and
  • Xiao Wang

12 March 2017

Laser flexible shock micro-bulging (LFSB) is a novel micro fabrication technology, which combines laser dynamic forming and flexible die forming, which is a type of high strain rate micro-forming. The LFSB of 304 stainless steel foils was investigate...

  • Article
  • Open Access
21 Citations
8,638 Views
11 Pages

30 December 2016

The hydraulic bulge test (HBT) method is proposed to determine material tensile strengths. The basic idea of HBT is similar to the small punch test (SPT), but inspired by the manufacturing process of rupture discs—high-pressure hydraulic oil is used...

  • Article
  • Open Access
6 Citations
4,113 Views
15 Pages

2 May 2021

We proposed a local one-sided rubber bulging method of metal tubes to evaluate various strain paths at an aimed portion and measured the forming limit strains of metal tubes at the place of the occurrence of necking under biaxial deformation. Using t...

  • Article
  • Open Access
2 Citations
2,356 Views
24 Pages

A submerged inlet has good stealth characteristics and a low external drag, but it also has the disadvantage of low internal flow efficiency. In view of this, a new efficiency enhancement method based on the prepositive synergistic bulge of the inlet...

  • Article
  • Open Access
4 Citations
2,436 Views
23 Pages

Numerical Study on the Formation Mechanism of Plume Bulge in the Pearl River Estuary under the Influence of River Discharge

  • Chenyu Zhao,
  • Nan Wang,
  • Yang Ding,
  • Dehai Song,
  • Junmin Li,
  • Mengqi Li,
  • Lingling Zhou,
  • Hang Yu,
  • Yanyu Chen and
  • Xianwen Bao

2 May 2024

Previous studies have investigated the characteristics and influencing factors of plume bulge in the Pearl River Estuary (PRE) using observations and numerical simulations. However, the understanding of how river discharge affects plume bulge is not...

  • Article
  • Open Access
5 Citations
1,837 Views
13 Pages

30 July 2023

High-pressure steam pipes inevitably suffered from the reciprocal interaction of high pressure and temperature during a long-period service, causing deformation and cracking. However, only limited studies about abnormal bulging caused by condensed wa...

  • Article
  • Open Access
473 Views
14 Pages

The Influence of Bulging Pressure on Hydraulic Forming of Bimetallic Composite Pipes

  • Yuntao Xi,
  • Zhonghao Gong,
  • Jiaxi Han,
  • Haiyan Li,
  • Liyan Zou,
  • Zesheng Zhou,
  • Jun Zhang,
  • Lanyun Li and
  • Lei Wang

5 November 2025

This article is based on ABAQUS 2022 finite element software to establish a finite element model of the hydraulic forming process of bimetallic composite pipes. The results show that the larger the bulging pressure, the earlier the circumferential el...

  • Article
  • Open Access
9 Citations
8,388 Views
13 Pages

Prediction of Lumbar Disc Bulging and Protrusion by Anthropometric Factors and Disc Morphology

  • Isabella Yu-Ju Hung,
  • Tiffany Ting-Fang Shih,
  • Bang-Bin Chen and
  • Yue Leon Guo

The relationship between reduced disc height and disc bulging and/or protrusion has been controversial. The purposes of this study were to examine the relationship between disc morphology and disc bulging and protrusion and to establish a model for p...

  • Article
  • Open Access
10 Citations
3,500 Views
15 Pages

30 December 2021

The TC/BC interface morphology in APS TBC is one of the important factors leading to crack propagation and coating failure. Long cracks are found near the bulge on the TC/BC interface. In this study, the TBC model with the bulge on the interface is d...

  • Review
  • Open Access
8 Citations
3,714 Views
24 Pages

25 March 2022

RR Lyrae stars are recognized as some of the oldest stars in the Universe. In addition, they are some of the few old celestial objects for which distances can be reliably inferred. As such, these stars are excellent tracers of the oldest structures t...

  • Article
  • Open Access
3 Citations
2,124 Views
21 Pages

Mold Size Effect in Microscale Laser Dynamic Flexible Bulging Assisted by Laser Pre-Shocking

  • Yijun Fang,
  • Pin Li,
  • Xijin Zhen,
  • Jindian Zhang and
  • Zongbao Shen

The size effect seriously affects the forming quality of micro-formed parts in the field of micro-forming. This paper focuses on the influence of the mold size effect in microscale laser dynamic flexible bulging (μLDFB). The experimental results i...

  • Article
  • Open Access
1 Citations
1,954 Views
16 Pages

Experimental Study on the Current Pretreatment-Assisted Free Bulging of 304 Stainless Steel Sheets

  • Jinchao Sun,
  • Gui Wang,
  • Qingjuan Zhao,
  • Jiafang Pan,
  • Yunfei Qu and
  • Yongxiang Su

25 June 2024

In order to further improve the microplastic deformation ability and forming performance of metal sheets, a pulse current pretreatment-assisted micro-forming method was proposed. Firstly, a 304 stainless steel sheet was pretreated with current (0&nda...

  • Article
  • Open Access
2,239 Views
25 Pages

13 March 2023

This study explored the buckling performance of bi-segment pressure hulls under external pressure. We fabricated bi-segment pressure hulls from bi-segment cylindrical preforms by using free bulging. The cylindrical preforms had a nominal thickness of...

  • Article
  • Open Access
1 Citations
1,645 Views
16 Pages

29 August 2023

Quenched residual stress in pentagon-curved forgings (PCGs) often leads to severe deformation during subsequent machining operations. This study aims to mitigate the quenched residual stress in PCGs through the implementation of the bulging method. T...

  • Article
  • Open Access
2 Citations
2,771 Views
18 Pages

13 August 2024

The hydraulic bulge test with micro-samples is expected to be useful in the damage assessment of long-service-period metals to understand the degeneration of their mechanical properties. Since the hydraulic bulge test has a different stress state fro...

  • Article
  • Open Access
279 Views
26 Pages

Stress–Strain and Dimension Evolution of Wind Turbine Bearing Ring with Non-Standard Section During Hot Bulging Process

  • Ruijie Gu,
  • Yutong Fu,
  • Ziyang Shang,
  • Zhuangya Zhang,
  • Shan Lan,
  • Tongxun Wang,
  • Qiang Wang and
  • Liaoyuan Chen

28 February 2026

As wind turbines trend toward larger sizes, higher rotational speeds, and extended service lives, higher demands are emerging for the dimensional accuracy, mechanical properties, and service reliability of the main shaft bearings. The hot bulging pro...

  • Article
  • Open Access
7 Citations
2,932 Views
12 Pages

27 April 2021

This study combined finite element method (FEM) simulations and physical experiments to develop a novel cold bulging process, with the aim of studying and mitigating the quenching residual stresses in 2A14 tapered cylinder forgings. The samples under...

  • Article
  • Open Access
1 Citations
1,771 Views
15 Pages

Study on Stamping–Bulging Process of Thin-Walled Superalloy Diaphragm for S-Shaped Bellows

  • Zhubin He,
  • Qingsong Zhao,
  • Kun Zhang,
  • Jian Ning,
  • Yi Xu and
  • Xianggang Ruan

10 June 2024

A combined stamping–bulging forming process was proposed to achieve high-precision forming of large-diameter, ultra-thin-walled, superalloy welded S-type corrugated diaphragms. The underlying principle is to enhance the diaphragm’s formin...

  • Article
  • Open Access
966 Views
17 Pages

22 May 2025

High-density polyethylene (HDPE) is a key material in modern engineering, highly valued for its versatility and wide range of applications. However, accurately assessing its mechanical performance under complex stress conditions has remained a challe...

  • Feature Paper
  • Article
  • Open Access
16 Citations
5,958 Views
10 Pages

29 October 2017

In this report, we investigate the efficiency and selectivity of a Zn2+-dependent peptide nucleic acid-based artificial ribonuclease (PNAzyme) that cleaves RNA target sequences. The target RNAs are varied to form different sizes (3 and 4 nucleotides,...

  • Article
  • Open Access
12 Citations
3,100 Views
24 Pages

Characteristics of the Rongcheng Bulge Geothermal Field and the Evolution of Geothermal Fluids, Xiong’an New Area, China

  • Hanxiong Zhang,
  • Guiling Wang,
  • Wei Zhang,
  • Feng Ma,
  • Xi Zhu,
  • Gaofan Yue and
  • Mingxiao Yu

10 August 2022

The study of geothermal field characteristics and the mechanisms involved in the hydrogeochemical evolution of geothermal fluids is an effective means to understand the formation, reservoir conditions and circulation mechanics of geothermal resources...

  • Article
  • Open Access
1 Citations
2,327 Views
13 Pages

Study on Bulge State of PCrNi3MoV Target Plates Penetrated by Square Fragments

  • Dou Hong,
  • Wenbin Li,
  • Yu Zheng,
  • Ning Jiang,
  • Kebin Zhang,
  • Zhonghua Liu and
  • Yao Jiang

10 July 2022

The objective of this study was to study the penetration characteristics of tungsten alloy fragments on PCrNi3MoV target plates. Specifically, the penetration of square tungsten alloy fragments of gun steel target plates of different thicknesses were...

  • Article
  • Open Access
4 Citations
3,259 Views
14 Pages

10 August 2022

Creep-associated changes in disc bulging and axial strains are essential for the research and development of mechano-bionic biomaterials and have been assessed in various ways in ex vivo creep studies. Nonetheless, the reported methods for measuremen...

  • Article
  • Open Access
3 Citations
1,835 Views
19 Pages

2 October 2023

In this study, innovative enhancements of rectangular tube-type buckling-restrained braces are proposed to prevent bulging failure on the surface of the outer restrainer and validated experimentally. First, an inner restrainer composed of a bent plat...

  • Article
  • Open Access
4 Citations
2,358 Views
37 Pages

24 October 2024

Rupture discs, also known as bursting discs, are indispensable components in fluid-operated systems providing effective protection against hazardous over-pressure or partial vacuum. They belong to a special class of safety devices and are found in a...

  • Article
  • Open Access
6 Citations
2,047 Views
12 Pages

Quantitative Analysis of Lumbar Disc Bulging in Patients with Lumbar Spinal Stenosis: Implication for Surgical Outcomes of Decompression Surgery

  • Koji Akeda,
  • Takahiro Hasegawa,
  • Yusuke Togo,
  • Kento Watanabe,
  • Koki Kawaguchi,
  • Junichi Yamada,
  • Norihiko Takegami,
  • Tatsuhiko Fujiwara and
  • Akihiro Sudo

24 September 2023

This study aimed to quantitatively assess disc bulging using computed tomography (CT) in patients with lumbar spinal stenosis (LSS) and to examine whether disc bulging affects the surgical outcomes of patients with LSS after posterior decompression s...

  • Article
  • Open Access
2 Citations
2,521 Views
14 Pages

18 November 2021

In an effort to improve impact energy-absorption characteristics, this study introduces a cylindrical crash absorber (CAP) with discontinuous protrusions and a continuous local-expansion plastic-forming method for its manufacture. The mechanical prop...

  • Article
  • Open Access
5 Citations
2,795 Views
16 Pages

Experimental and Numerical Thickness Analysis of TRIP Steel under Various Degrees of Deformation in Bulge Test

  • Emil Spišák,
  • Janka Majerníková,
  • Ľuboš Kaščák,
  • Peter Mulidrán,
  • Vladimír Rohaľ and
  • Róbert Bidulský

20 March 2022

To design a reliable forming process it is necessary to determine the mechanical and formability properties of the processed material, which are used as input parameters for forming simulations. High-strength steel is irreplaceable as a material for...

  • Article
  • Open Access
10 Citations
4,212 Views
18 Pages

Elasticity of Cross-Linked Titania Nanocrystal Assemblies Probed by AFM-Bulge Tests

  • Andreas Hensel,
  • Clemens J. Schröter,
  • Hendrik Schlicke,
  • Norbert Schulz,
  • Svenja Riekeberg,
  • Hoc Khiem Trieu,
  • Andreas Stierle,
  • Heshmat Noei,
  • Horst Weller and
  • Tobias Vossmeyer

29 August 2019

In order to enable advanced technological applications of nanocrystal composites, e.g., as functional coatings and layers in flexible optics and electronics, it is necessary to understand and control their mechanical properties. The objective of this...

  • Article
  • Open Access
15 Citations
9,201 Views
17 Pages

16 June 2021

The study concerns a protection system applied against kinetic-energy penetrators (KEPs) composed of steel plates sandwiching a rubber layer. Laminated steel-elastomer armours represent non-explosive reactive (NERA) armours that take advantage of a s...

  • Article
  • Open Access
16 Citations
4,263 Views
22 Pages

17 February 2023

The rocket nozzle is one of the core components to ensure the safe flight of rockets. To overcome the problems of multi-step forming, the occurrence of defects, and severe plastic deformation in traditional technology, a novel forming method named tu...

  • Article
  • Open Access
2 Citations
1,944 Views
27 Pages

27 June 2023

We propose an experimental method to identify anisotropic coefficients in non-principal axis directions of thin-walled tubes. The method involves extracting specimens from the parent tubes and machining a hole in the axial center. The specimens are t...

  • Article
  • Open Access
350 Views
22 Pages

Circumferential Bulging Variation and Temperature Distribution of Profile-Tunable Roll for Freeform Optics in Roll-to-Plate (R2P) Hot-Embossing Process

  • Yanfeng Feng,
  • Lixiong Luo,
  • Yujie Zhou,
  • Zhiqiang Xu,
  • Tingsong Yang,
  • Chao Hong,
  • Benshuai Ruan,
  • Shengwei Li and
  • Chao Yan

11 December 2025

The roll-to-plate (R2P) hot-embossing process is a newly developed molding technique for the high-throughput, high-efficiency fabrication of large-area microstructured optical elements. However, this technology is limited to flat surfaces, because th...

  • Article
  • Open Access
8 Citations
5,528 Views
11 Pages

16 March 2017

Severe surface roughening during the hydroforming of aluminum alloy parts can produce surface defects that severely restrict their application in the automobile and aerospace industry. To understand the relation between strain, grain size and surface...

  • Article
  • Open Access
2 Citations
3,076 Views
11 Pages

4 March 2020

In this paper, homogeneous polystyrene (PS) microspheres with controllable sizes of 40 nm, 80 nm, and 120 nm were synthesized by controlling the temperature of solvothermal method. In order to explore the effect of PS microspheres on dielectric-hydro...

  • Article
  • Open Access
1,455 Views
32 Pages

Influence of Loading Mode on the Biaxial Stress–Strain Curve at Hydraulic Bulge Test

  • Jiří Sobotka,
  • Pavel Solfronk,
  • Martin Švec and
  • David Koreček

25 November 2024

Stress–strain curves are generally a very important material characteristic. For example, in numerical simulations, especially in sheet metal forming, stress–strain curves represent one of the most important data inputs. However, there is...

  • Article
  • Open Access
6 Citations
5,360 Views
15 Pages

Development of a Machine Learning Algorithm to Correlate Lumbar Disc Height on X-rays with Disc Bulging or Herniation

  • Pao-Chun Lin,
  • Wei-Shan Chang,
  • Kai-Yuan Hsiao,
  • Hon-Man Liu,
  • Ben-Chang Shia,
  • Ming-Chih Chen,
  • Po-Yu Hsieh,
  • Tseng-Wei Lai,
  • Feng-Huei Lin and
  • Che-Cheng Chang

Lumbar disc bulging or herniation (LDBH) is one of the major causes of spinal stenosis and related nerve compression, and its severity is the major determinant for spine surgery. MRI of the spine is the most important diagnostic tool for evaluating t...

  • Article
  • Open Access
3 Citations
2,513 Views
17 Pages

A Laminated Spherical Tsunami Shelter with an Elastic Buffer Layer and Its Integrated Bulge Processing Method

  • Junfu Hou,
  • Li Chen,
  • Jingchao Guan,
  • Wei Zhao,
  • Ichirou Hagiwara and
  • Xilu Zhao

20 July 2023

When a tsunami occurs, people can enter floating shelters and save their lives. Tsunami shelters consisting of thin-walled fiber-reinforced plastic (FRP) spherical shells have been developed and are currently in use. In this study, a novel three-laye...

  • Article
  • Open Access
2 Citations
2,465 Views
21 Pages

Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

  • Jiao Wang,
  • Yifei Qiu,
  • Yansheng Zhu,
  • Xuejiao Ren,
  • Xiaoqi Zhou,
  • Xia Wang,
  • Huiyang Song,
  • Jianhao Li,
  • Chengming Gao and
  • Pengbo Cao
  • + 1 author

Outer bulge (OB) hair follicle stem cells (HFSCs) play a crucial role in maintaining hair follicle structural stability and regulating the hair follicle cycle. Previous studies demonstrated that keratin 24 (Krt24) exhibits spatiotemporally restricted...

  • Article
  • Open Access
6 Citations
3,489 Views
19 Pages

15 January 2021

This study investigated the effects of different substrates on the mechanical properties of Ti-60at%Ni shape memory alloys (SMA). Two types of samples were prepared for this experiment: (1) a Ti-60at%Ni deposited on SiNx, and (2) a Ti-60at%Ni deposit...

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