Search Results (3,748)

Since the COVID-19 pandemic, wastewater monitoring has become an additional tool in the surveillance of infectious diseases. Many EU countries put wastewater surveillance systems (WSS) in place to track SARS-CoV-2 and its variants and other pathogens, such as the influenza virus or Respiratory syncytial virus (RSV). In Germany, several research and pilot projects funded by the EU, the Federal Ministry of Education and Research, the Federal Ministry of Health, and projects at Federal State level have been launched in the last four years. In Germany, wastewater monitoring was not implemented as a public health tool before the COVID-19 pandemic, but in September 2022, it has been legally determined in the German infection protection act (Infektionsschutzgesetz, IfSG). As Germany is a federal state, competencies in epidemic management partly belong to the 16 federal states (“Länder”). In the federal states, the local health authorities at the county (“Kreise”) level also have specific risk management and communication competencies. Furthermore, WSS has been incorporated into the revised Urban Wastewater Treatment Directive (EU) 2024/3019. For this reason, the federal states and local health authorities play a pivotal role in successfully implementing wastewater monitoring as a supplementary component of disease surveillance in Germany. Between November 2021 and August 2022, the federal state of Thuringia, Germany, supported a pilot study to implement a surveillance system for SARS-CoV-2-RNA in wastewater of 23 wastewater treatment plants in 17 counties in Thuringia. Here, we describe the study design and the system behind the logistics and the planning, and we provide an overview of the options for involving the public health service. Furthermore, the possibilities for IT concepts and approaches to innovative AI solutions are shown. We also aim to explore the feasibility and potential barriers to further implementing wastewater surveillance as a supplementary public health tool in Thuringia. Full article

Chronic back pain (CBP) associated with intervertebral disc degeneration (IVDD) is a leading cause of medical consultations, decreased quality of life, and temporary and permanent disability. The mechanisms of CBP development and persistence in patients with IVDD have been studied for many years, but this issue remains far from resolved. The search for predictive biomarkers that could help identify patients with IVDD at high risk for CBP continues. In recent decades, research has shown increasing interest in identifying epigenetic biomarkers for this disorder. to summarize the results of preclinical and clinical studies on the role of microRNAs (miRs) as epigenetic biomarkers of the development and progression of CBP in patients with IVDD. English-language articles; original experimental (preclinical) studies; original clinical study; assessment of changes in systemic (in blood) and/or local (in intervertebral disk (IVD)) levels of miR expression in IVDD, either independently or in comparison with healthy controls; and studies that were completed and the results of which were published. PubMed, Springer, Google Scholar, Scopus, Oxford Press, Cochrane, and e-Library databases. Charting for this scoping review involved developing a data extraction form to summarize extracts and organize data from included studies. This was an iterative process where the charting tables and figures may be refined as the review progresses. 126 studies were analyzed in detail, focusing on their study designs and comparing changes in miR expression in animal models of IVDD and in patients with IVDD compared to healthy controls. During the preparation of this scoping review and upon subsequent detailed review of the original publications, it turned out that the results of one study were not justified by the authors due to identified technological problems (the article was withdrawn by the editorial board of the journal). Therefore, we excluded the results of this study from the subsequent analysis. As a result, this section summarizes the results of 60 preclinical and 65 clinical studies. Some miRs (e.g., miR-21 and miR-132) are associated with the regulation of inflammatory pathways that contribute to increased degradation of IVD extracellular matrix and enhanced nociceptive signaling through various mechanisms, contributing to the progression of CBP. Other miRs (e.g., miR-145 and miR-223) exert protective effects, enhance regenerative potential, and alleviate CBP. Despite the promising results of these studies, there are limitations in the use of miRs as perspective epigenetic biomarkers of CBP in patients with IVDD because the pattern of potentially predictive and protective miRs in relation to the mechanisms of CBP formation and progression in IVDD has not yet been sufficiently studied. The results of some preclinical and clinical studies are contradictory. Further research is needed to clarify the role of miR signatures in animal models and clinical trials on IVDD-specific CBP. Full article

Postsocialist peri-urban spaces are characterized by a chaotic development as a result of the transition from communism to capitalism. Recent research has highlighted that liveability in peri-urban spaces encounters challenges of adaptation to the peri-urban areas. The aim of the present study is to identify and analyze patterns and contrasts that occur between age groups and gender in relation to the level of liveability as well as to better understand the daily mobility practices and commuting dependencies and how mobility shapes key contrasts and emerging tensions within Timișoara’s postsocialist peri-urban spaces. As liveability relates to local development, commuting, and accessibility to service facilities in the residential environment, the identification of patterns and differences is imperative when considering the perception of local residents on potential (un)sustainable liveability in peri-urban areas. This study utilizes a quantitative analysis, informed by a survey of considerable size (N = 954) conducted in peri-urban settlements of Timisoara, Romania, with a view to elucidating the distinctions and commonalities in the perceptions held by the local populace. The findings indicate that the elderly population exhibits a greater reluctance to adapt to the emerging peri-urban environment. In contrast, the younger and more educated demographic demonstrates a higher degree of adaptability to the contemporary challenges posed by peri-urban expansion and hazardous development. Daily mobility, including commuting, is directly influenced by the effects of dispersed and chaotic development (e.g., more than 79% of respondents rely on private cars for commuting), as well as the lack of facilities and services (e.g., 2.21 level of satisfaction regarding cultural events). This highlights Timisoara’s dependence on external services, as well as the significant role of personal vehicles in providing access to the city center and its neighborhoods. Therefore, we can observe the peri-urban area undergoing a transitional phase as it navigates the initial stages of sustainable urban development and pursues an enhanced quality of life. Finally, we propose several policy recommendations for local authorities, offering solutions for enhancing liveability in peri-urban areas. Full article

This study examines the social factors shaping solar energy transitioning in Zambia’s mining sector, a key contributor to the national resource economy. It focuses on how policies, incentive systems, communication channels, training and skills development, and stakeholder engagement and partnership influence the sector’s readiness to adopt solar energy and support more reliable operations. A quantitative design was used, with a 5-point Likert-scale questionnaire administered to 192 respondents from mining companies, regulatory bodies, energy suppliers and local authorities. Data were analysed using descriptive statistics, reliability tests and hierarchical regression. The results show that stakeholder engagement and partnership and incentive systems are the strongest predictors of transition intentions, underscoring their role in improving energy security and supporting sustainable production. Policies, communication and training had weaker effects, indicating the need for stronger institutional coordination and targeted capacity building. Overall, the findings illustrate how social conditions shape renewable energy adoption and contribute to more resilient mining activities. Full article

This study explores the development potential of thematic tourism in the Municipality of Pella, Northern Greece. It examines local residents’ perceptions regarding tourism as a growth strategy, evaluates current informational and promotional efforts by the local government, and assesses the public’s willingness to participate in tourism activities. A structured questionnaire was distributed to a representative sample of residents that was given both in person and via the internet. Quantitative analysis revealed that while respondents generally support the idea of tourism development and feel moderately informed, there is a strong perception that the municipality’s efforts to promote tourism are insufficient. Key factors influencing residents’ attitudes include age, level of education, and personal involvement with tourism. The findings suggest that thematic tourism could serve as a viable development path, provided that local authorities implement targeted education, infrastructure, and promotion strategies. This study recommends enhanced cooperation between public institutions and local stakeholders to support sustainable tourism growth. It is suggested, therefore, to increase the depth of focus given in the development of an innovative agricultural area development model that will combine traditional agriculture with agritourism and the remaining types according to each place’s capabilities. Full article

Foundational biomedical sciences are commonly taught without routine integration of local population health contexts, limiting students’ ability to connect mechanisms to community disease burden and practice responsibilities. In this method paper, we developed and piloted an AI-enabled “Sacramento County Public Health (SACPH)” AI workflow and app prototype, a structured, faculty-authored prompt sequence designed to guide population-to-practice reasoning using publicly available data. The workflow was implemented during a TBL session with first-year PharmD students in an immunology course. Using splenectomy and risk of overwhelming post-splenectomy infection (OPSI) as an illustrative use case, students executed a standardized prompt sequence addressing data source identification, coding logic (diagnosis vs. procedure codes), population-level estimation with uncertainty framing, and translation to pharmacist-relevant prevention and counseling implications. Feasibility was defined by conceptual convergence. The validated reasoning workflow was subsequently translated into a prototype, app-style interface using generative design prompts. Across student teams, outputs converged on similar categories, consistent recognition of coding frameworks and verification steps, and directionally similar interpretations of local burden and pharmacist responsibilities. The prototype demonstrated successful externalization of the reasoning workflow into a modular, reproducible artifact. SACPH demonstrates a feasible, reproducible method for using generative AI to integrate foundational science instruction with local population health context and pharmacist practice reasoning, while supporting AI literacy competencies. Full article

The rapid development of electromobility increases the need for fast, accessible and robust charging stations devoted to EVs (electric vehicles). Planning a network of such stations poses new challenges—amongst others, a power supply that may power such chargers. One major concept is to utilise wind energy as a power source. The paper analyses meteorological data gathered since 2001 in several stations across Poland to achieve quantitative indexes, which summarise (a) wind power density (WPD) as a metric of energy amount, (b) long-term (multiannual) time trends of amount of energy, (c) short-term stability (and thus predictability) of the wind power. The indexes that cover the abovementioned factors allow the authors to answer the research questions, where the local wind conditions allow the authors to consider the integration of a wind powerplant and a network of EV chargers. Additionally, we investigated locations where the amount of available energy is sufficient, but the variability of wind power impedes its practical exploitation. In such cases, the power system may be extended by an energy storage system that acts as a buffer, smoothing power fluctuations and thereby improving the robustness and reliability of downstream charging systems. Full article

Hard-to-heal wounds remain a significant challenge for healthcare professionals, particularly in aging populations. Although most chronic wounds are associated with diabetes or chronic venous insufficiency, rare etiologies should also be considered. One such cause is envenomation by Phoneutria spp. (native to South America, rare in Europe). Their venom contains potent neurotoxins. While systemic manifestations are more commonly reported, localized necrotic skin lesions may also occur. This case report presents a rare chronic wound following a suspected Phoneutria spider bite and highlights the importance of an individualized, multimodal treatment approach. A 61-year-old male patient with a progressive thigh wound following a spider bite sustained during work. Despite initial self-treatment and pharmacotherapy the wound deteriorated. The patient was admitted to the authors’ facility, where surgical treatment included necrosectomy and a sandwich graft using an acellular dermal matrix combined with a split-thickness skin graft. Adjunctive therapies included negative pressure wound therapy and hyperbaric oxygen therapy. After discharge, outpatient wound care was continued. Treatment was monitored with photographic documentation and serial microperfusion measurements. Complete wound closure was achieved after 4 months of specialized therapy. Management of chronic wounds requires a multidisciplinary and individualized approach with surgical intervention, advanced wound care and specialized outpatient follow-up. Full article

Flooding is an increasing climate risk in the UK, yet schools remain marginal in resilience planning. Flood events disrupt education, heighten pupil anxiety, increase staff workload and unsettle communities, but these experiences are rarely documented in ways that inform policy. This study examines how schools in the East and West Midlands regions of the UK have experienced and adapted to flooding. Eight qualitative case studies were undertaken in flood-affected schools using semi-structured interviews with key staff, site visits and documentary evidence. Interview transcripts were thematically analysed using NVivo to explore past flood events, levels of preparedness, and readiness for measures such as Property Flood Resilience, Sustainable Drainage Systems and Climate Action Plans. Findings show wide variation in awareness, emergency procedures and engagement with local authorities. Most schools had faced flooding or near misses but lacked formal guidance or flood-specific plans, leading to improvised responses led internally by staff. Despite limited funding, inconsistent communication and exclusion from wider planning, schools demonstrated adaptive potential and willingness to support community preparedness. The study offers evidence to guide headteachers, policymakers and local authorities in strengthening school-based flood resilience and supporting the development of a resilience innovation blueprint for flood-prone schools in the UK. Full article

Recurrent canine cervical sialocele is most often caused by incomplete excision of the mandibular–sublingual gland complex, leading to anatomical distortion and concealment of residual tissue. This case describes the multimodal management of a repeatedly recurrent cervical sialocele in a young, small-breed dog following multiple previous revision surgeries. A stepwise bridging strategy was adopted before definitive salvage surgery. Oral phenobarbital was instituted, resulting in partial reduction in fluid accumulation and improved comfort. Ultrasound-guided intracavitary sclerotherapy with OK-432 was then performed, inducing a localized fibrotic response but without durable cure. Final resolution was achieved only after salvage ventral paramedian (VPM) sialoadenectomy, which provided wide exposure for complete excision of deeply concealed sublingual remnant tissue within a fibrotic pseudocapsule. Histology confirmed a cervical sialocele. Transient neuropraxia resolved within 3 weeks, and no recurrence was observed at 6 months postoperatively. To the authors’ knowledge, this is the first report describing intracavitary OK-432 sclerotherapy as part of a staged multimodal strategy for canine cervical sialocele. This case illustrates the feasibility of integrating medical salivary suppression and minimally invasive sclerotherapy as bridging measures before salvage VPM surgery for refractory cervical sialocele. Full article

This study suggests the concept of multifunctional social spaces (MSSs) as intergenerational communication platforms, contributing to SDG achievement and environment awareness in local communities. Retirees could perform socially significant practices via local MSS premises supported by municipalities and initiative groups. The basic social vector of an MSS is supposed to produce a synergy effect with the educational and environmental impetus of the Sustainable Environmental Education (SEE) approach. Lifelong education underlies the process of adapting various age groups to different local spaces, namely metropolis, suburb, or rural areas. Test qualitative interviews were conducted with pensioners and young people to discover attitudes towards MSS-prescribed functions within different reference groups. These interviews helped to define the preferred communication instruments for MSS operation. General types of MSSs were classified based on mini case studies. MSS introduction is supposed to influence basic social indices such as population health, life expectancy, and fertility levels in the long term, and support several environmental awareness markers. Future studies could examine such influences in detail and discuss more national and regional specifics. Municipal and regional authorities, as well as local community leaders, could use the results of this study to consider local development, SDG strategies, and roadmaps. Full article

Around eight million people—mainly in cities—die prematurely from pollution-related diseases; thus, studies of urban dust have become increasingly relevant over the last two decades. In this study, an assessment of heavy metal and metalloid contamination in urban dust was conducted in downtown Murcia, Spain. The objectives were to evaluate the level of contamination and the associated health risks, both with a spatially explicit focus. One hundred and twenty-eight urban dust samples were collected, each from a 1-square-meter area, using plastic tools to prevent contamination. The dust was dried and weighed, then acid-digested before analysis via inductively coupled plasma mass spectrometry. Corresponding maps were then generated using a geographic information system. The elements analyzed in the urban dust (with their median concentrations, given in mg/kg) were As (2.14), Bi (14.06), Cd (0.38), Co (1.88), Cr (71.17), Cu (142.60), Fe (13,752), Mn (316.64), Mo (3.90), Ni (21.94), Pb (106.27), Sb (6.54), Se (4.34), Sr (488.08), V (28.05), and Zn (357.33). The sequence of median concentrations for the analyzed elements was Fe > Sr > Zn > Mn > Cu > Pb > Cr > V > Ni > Bi > Sb > Se > Mo > As > Co > Cd. The pollution assessment reveals that the city is moderately polluted. Using local background levels, the elements with median values exceeding the threshold for considerable contamination were As, Cu, Pb, Sb, Se, and Zn. Using the global background level, the elements with median values exceeding the threshold for considerable contamination were Bi, Cu, Mo, Pb, Sb, Se, and Zn. The median value of the sum of the hazard index (1.82) indicates a risk to children’s health. The hazard index revealed that 43% of the sites pose a relative risk to children. In contrast to previous global studies, the present research provides a multi-scale assessment of urban pollution and health risks. Pollution is evaluated by metal, city, zone, and site, while health risks are assessed by metal, city, and site. We recommend a strategy for both local authorities and residents. Full article

This study introduces the Sustainable Urban Mobility Maturity Model (SUM-MM) to assess and enhance the maturity of sustainable urban mobility in cities. The SUM-MM comprises 3 main dimensions (enablers, sustainability, and transport modes) and 11 sub-dimensions (strategic and spatial planning, organization and human resources, information and communication technologies, environment, economy, social, walking, micromobility, public transport, paratransit systems, and multimodal integration), evaluated at 5 levels (beginner, initial, integrated, managed, and mature). Developed through a literature review and validated using a questionnaire-based expert opinion method, the model was tested in Konya, Türkiye. The results show that Konya’s overall maturity falls between integrated and managed, with significant variability across sub-dimensions. The enablers dimension demonstrated the highest maturity, driven by strong organizational and technological capabilities, whereas the transport modes dimension had the lowest—particularly in paratransit systems. The SUM-MM serves as both a benchmarking tool and a policy guidance framework, facilitating targeted strategies for sustainable urban mobility improvements. Unlike existing smart city or transport maturity models, the SUM-MM specifically focuses on sustainable urban mobility, offering a structured, operational, and decision-oriented framework for policy-makers and city administrations. The results can be used by local and national authorities to support comparative benchmarking, strategic planning, and the prioritization of sustainable urban mobility investments. Full article

In parametric statistics, it is well established that the canonical measures of estimator performance—such as bias, variance, and mean squared error—are inherently dependent on the parameterization of the model. Consequently, these quantities describe the behavior of an estimator only relative to a particular parameterization, rather than representing intrinsic properties of either the estimator itself or the underlying probability distribution it seeks to estimate. Some years ago, the authors introduced a framework, termed the intrinsic analysis of point estimation, in which tools from information geometry were employed to construct analogues of classical statistical notions that are intrinsic to both the estimator and the associated probability measure. Within this framework, a contravariant vector field was introduced to define the intrinsic bias, while the squared Riemannian distance naturally emerged as the intrinsic analogue of the classical squared distance. Intrinsic counterparts of the Cramér–Rao inequalities, as well as the Rao–Blackwell and Lehmann–Scheffé theorems, were also established. The present work extends the intrinsic analysis—originally founded on the concept of intrinsic risk, a fundamentally local measure of estimator performance—to an approach that characterizes the estimator over an entire region of the parameter space, thereby yielding an intrinsically global perspective. Building upon intrinsic risk, two indices are proposed to evaluate estimator performance within a bounded region: (i) the integral of the intrinsic risk with respect to the Riemannian volume over the specified region, and (ii) the maximum intrinsic risk attained within that region. The Riemannian volume induced by the Fisher information metric on the manifold associated with the parametric model provides a natural means of averaging the intrinsic risk. Using variational methods, integral inequalities of the Cramér–Rao type are derived for the mean squared integrated Rao distance of the estimators, thereby extending previous contributions by several authors. Furthermore, lower bounds for the maximum intrinsic risk are obtained through corresponding integral formulations. Full article

Women play a key role in Greek olive cultivation, a sector at the heart of local economies currently facing increasing pressures from climate change. This study explores gender roles, responsibilities, and access to resources shaping the adoption of sustainable agriculture practices. Through in-depth interviews with female farmers on the island of Crete, the results show that women face limited access to training and financial services as well as gender-based discrimination and the hidden caregiving and house working tasks. However, they manifest a strong openness towards sustainable practices, driven by environmental values, even among those lacking decision-making authority. Despite these challenges, women show a positive attitude toward learning and innovation, calling for more institutional support and training opportunities. This study sheds light on the need for recognition of women’s roles in agriculture, particularly in the context of climate adaptation, and offers practical recommendations to improve gender roles within the olive sector. Full article