Hybrid and Chimeric Heterocycles: A Promising Approach to Synthesizing Biologically Active Compounds
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 December 2025 | Viewed by 278
Special Issue Editor
Interests: heterocycles; medicinal chemistry; anticancer; antituberculosis; microwave; ultrasounds; organic synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A literature survey revealed that heterocycles are privileged core scaffolds in medicinal chemistry, playing an essential role in drug design and reported to exhibit many biological and pharmacological activities, including antimicrobial, antiviral, anthelmintic, anti-HIV, anticancer, antiallergic, diuretics, cardiotonics, antihypertensive, antiplatelet, analgesic, anxiolytic, antidepressant, hypnotic sedative, antineurodegenerative, anti-Alzheimer’s, etc.
Despite the recent progress in obtaining new drugs with various biological activities in medicinal chemistry, there is an urgent need, in both the pharmaceutical industry and society, for new drugs with better activity, lower toxicity and enhanced properties. One of the most promising approaches used by scientists in the design of new drugs is the Multiple Targeting Drugs (MTD) approach, where a single chemical structure interacts with two or more distinct biological targets associated with a disease, resulting in new drug candidates with improved pharmacodynamic, pharmacokinetic and toxicologic properties and better patient compliance. Usually drug candidates in the Multiple Targeting Drugs approach are classified as Hybrid Drugs (HDs) or Chimeric Drugs (CDs). However, despite the advantages described above, both HDs and CDs have some drawbacks, such as decreases in target binding efficiency, side effects, toxicity, etc.
The aim of this Special Issue is to present the latest developments in biologically active compounds with a hybrid and/or chimeric heterocyclic core, with a focus on the synthesis, structure and biological activity of these compounds.
Prof. Dr. Ionel Mangalagiu
Guest Editor
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Keywords
- hybrid heterocyclic compounds
- chimeric heterocyclic compounds
- multifactorial diseases
- multiple targeting drugs
- biological activity: antimicrobials, antiviral, anthelmintic, anti-HIV, anticancer, antiallergic, diuretics, cardiotonic, antihypertensive, antiplatelet, analgesic, anxiolytics, antidepressant, hypnotic sedative, antineurodegenerative, anti-Alzheimer’s etc.
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