Chirality in Drugs
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 26 December 2025 | Viewed by 13
Special Issue Editor
Interests: chiral drugs; natural products; structure elucidation; chiral sensing; quantum-chemical calculation; chiroptical spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pharmaceutical industry has increasingly recognized the critical importance of molecular chirality in drug development, with a substantial proportion of newly approved therapeutic agents exhibiting stereochemical complexity. This trend reflects the growing understanding of how stereochemical configuration influences pharmacological activity, bioavailability, and therapeutic efficacy.
Contemporary drug development pipelines are demonstrating a rising incidence of stereochemically sophisticated pharmaceuticals, necessitating innovative synthetic strategies and advanced analytical methodologies. The field of asymmetric synthesis currently grapples with three core technical obstacles: exact stereochemical manipulation within structurally intricate molecular frameworks, economically feasible manufacturing of optically pure substances, and optimized isolation methodologies for stereoisomeric mixtures. Concurrently, advanced analytical methodologies are required to characterize subtle stereochemical differences, quantify enantiomeric excess, and monitor chiral integrity throughout the drug development lifecycle. The integration of these synthetic and analytical capabilities is becoming indispensable for developing next-generation therapeutics with optimized stereochemical profiles and improved clinical outcomes.
In the Special Issue titled "Chirality in Drugs," both reviews and original articles are invited. Topics include all aspects of chiral drug research, such as asymmetric synthesis, chiral resolution, chiral analysis, chiroptical spectroscopy, and the biological assessment of stereoisomers. The collection of manuscripts will be published as a Special Issue of the journal.
Prof. Dr. Li Li
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chirality
- chiral drugs
- chiral resolution
- asymmetric synthesis
- chiral analysis
- chiroptical spectroscopy
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