Advances in Medicinal Chemistry: 2nd Edition

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 65

Special Issue Editor


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Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152−160 Pearse Street, D02 R590 Dublin, Ireland
Interests: drug development; antiestrogens; in silico; breast cancer; design and synthesis; synthetic methods; amphetamines; anticancer drug design; carbapenem antibiotics; chemistry of drug metabolism; chemistry of drug receptor interactions; design and synthesis of drugs; molecular modelling of estrogen receptor antagonists; pharmacologically active heterocycles
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Special Issue Information

Dear Colleagues,

As a multidisciplinary research subject, medicinal chemistry involves topics within biology, medicine, chemistry, and other therapeutic fields, ranging from anticancer, antiviral, and antimicrobial agents to molecules that are potentially active in endocrine, inflammation, neurological, cardiovascular, and autoimmune diseases. The numerous advances in this field, ranging from theoretical design and in silico screening to synthetic and analytical methodologies, lead discovery and optimization methods, structure-based drug design, and bioinformatics, are contributing to more efficient and sophisticated strategies to access therapeutic potential.

This Special Issue aims to discuss new knowledge and cutting-edge developments related to all aspects of medicinal chemistry, which will contribute to our understanding of the relationship between molecular structure and biological activity or the mode of action of drugs. Authors are invited to contribute original research papers or reviews that report on the discovery, design, synthesis, identification, and metabolism of biologically active compounds and drug candidates, together with structure–activity relationships and studies that describe investigations of the mechanism of action at the molecular level of these novel biologically active compounds.

Prof. Dr. Mary J. Meegan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • novel drug targets
  • drug discovery
  • drug design and development
  • synthetic methods for drugs
  • analytical methodologies
  • in silico screening
  • structure and ligand-based drug design
  • structure–activity relationships (SAR)
  • drug metabolism

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Published Papers

This special issue is now open for submission.
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