Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 22 February 2026 | Viewed by 50
Special Issue Editors
Interests: synthesis; 1,2-benzothiazine; oxicams; anti-inflammatory; chemoprevention; cancer
Special Issues, Collections and Topics in MDPI journals
Interests: intermolecular interactions; drug design; molecular modeling; molecular docking; protein conformation; protein binding
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocyclic compounds are attractive and frequently studied molecules in medicinal chemistry and chemical biology. These compounds are the building blocks of both natural and synthetic compounds, such as drugs, pesticides, herbicides, dyes, and others. The most common are heterocyclic five- and six-membered nitrogen compounds, such as pyridine, pyrimidine, piperazine, pyrazole, and imidazole. Oxazines and thiazines are slightly less common but they also receive considerable attention as either core scaffolds or a peripheral substituents. Both thiazine and oxazine are six-membered rings containing two heteroatoms: thiazine with nitrogen and sulfur, and oxazine with nitrogen and oxygen. Oxazine scaffold-containing compounds and thiazine scaffold-containing compounds have been identified as pharmacologically interesting molecules with a wide range of biological effects, from anti-inflammatory to antibacterial, antiviral, antidiabetic, and anticancer properties, and the list continues to grow.
In this Special Issue of the journal Pharmaceuticals, we are pleased to welcome articles describing research on the synthesis and biological testing of compounds containing a thiazine or oxazine ring in their structure. These may be entirely new compounds or known compounds studied from a new perspective, as there is growing interest in repurposing old drugs for new therapeutic purposes. These may include innovative methods for the synthesis of thiazine or oxazine derivatives. These may also include physicochemical studies of these compounds, providing new knowledge about them. We cordially invite you to submit scientific articles and reviews for this Special Issue and we look forward to receiving your contributions.
Dr. Berenika M. Szczȩśniak-Siȩga
Dr. Żaneta Czyżnikowska
Guest Editors
Manuscript Submission Information
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Keywords
- thiazine
- oxazine
- morpholine
- thiomorpholine
- benzothiazine
- phenothiazine
- synthesis
- drug
- anti-inflammatory
- anticancer
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