Novel Developments in Antileishmanial and Antitrypanosomal Agents
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 71
Special Issue Editors
Interests: parasitology; neglected tropical diseases; infectious diseases; drug discovery; medicinal chemistry; chemical biology; bioinformatics; proteomics
Interests: medicinal chemistry; organic chemistry; bioorganic chemistry; neglected tropical diseases
Special Issue Information
Dear Colleagues,
Trypanosomatid diseases, such as leishmaniasis and Chagas disease, represent significant global health threats, affecting millions worldwide, primarily in resource-limited regions. Despite the severe morbidity, mortality, and socioeconomic burdens associated with these infections, current therapeutic options are limited, often plagued by issues such as toxicity, resistance, complex administration protocols, and inadequate efficacy.
This Special Issue, titled “Novel Developments in Antileishmanial and Antitrypanosomal Agents”, aims to address this critical gap by gathering cutting-edge research focused on the discovery and development of innovative therapeutic agents targeting Leishmania and Trypanosoma parasites. Contributions highlighting novel chemical entities, natural products, drug repositioning strategies, structure-based drug design, and target validation approaches are particularly encouraged. Manuscripts detailing mechanistic insights, pharmacokinetics, pharmacodynamics, and resistance mechanisms, alongside rigorous in vitro and/or in vivo evaluations, are warmly welcomed.
We invite researchers working in medicinal chemistry, pharmacology, structural biology, and related disciplines to submit original articles, reviews, or short communications that explore new frontiers in antileishmanial and antitrypanosomal drug discovery. Through this collective effort, we aim to facilitate the translation of scientific advances into clinically impactful therapies, ultimately contributing to improved global health outcomes.
Dr. Exequiel Porta
Prof. Dr. Guillermo Labadie
Dr. Brian Suárez Mantilla
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antileishmanial
- antitrypanosomal
- Chagas disease
- human African Trypanosomiasis (sleeping sickness)
- leishmaniasis
- drug discovery
- medicinal chemistry
- natural products
- drug repurposing
- trypanosomatids
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