Pharmaceuticals, Volume 18, Issue 8
2025 August - 162 articles
Cover Story: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of anticancer drugs like paclitaxel and lacks effective preventive treatments. In this study, BMX-001, a redox-active manganese metalloporphyrin, was investigated for its dual capacity to protect healthy cells while promoting oxidative stress in cancer cells. In vitro, BMX-001 reduced reactive oxygen species (ROS), inflammation, and antioxidant enzyme disruption in satellite glial cells, while increasing ROS in breast cancer cells. In vivo, BMX-001 alleviated mechanical, cold, and thermal hypersensitivity in a CIPN mouse model and reduced neuroinflammation. These findings support BMX-001 as a promising adjunct to chemotherapy for mitigating CIPN and enhancing anticancer efficacy. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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