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Pharmaceuticals, Volume 18, Issue 8

2025 August - 162 articles

Cover Story: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of anticancer drugs like paclitaxel and lacks effective preventive treatments. In this study, BMX-001, a redox-active manganese metalloporphyrin, was investigated for its dual capacity to protect healthy cells while promoting oxidative stress in cancer cells. In vitro, BMX-001 reduced reactive oxygen species (ROS), inflammation, and antioxidant enzyme disruption in satellite glial cells, while increasing ROS in breast cancer cells. In vivo, BMX-001 alleviated mechanical, cold, and thermal hypersensitivity in a CIPN mouse model and reduced neuroinflammation. These findings support BMX-001 as a promising adjunct to chemotherapy for mitigating CIPN and enhancing anticancer efficacy. View this paper
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Articles (162)

  • Article
  • Open Access
1,740 Views
21 Pages
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Network Pharmacology and Experimental Validation Identify Paeoniflorin as a Novel SRC-Targeted Therapy for Castration-Resistant Prostate Cancer

  • Meng-Yao Xu,
  • Jun-Biao Zhang,
  • Yu-Zheng Peng,
  • Mei-Cheng Liu,
  • Si-Yang Ma,
  • Ye Zhou,
  • Zhi-Hua Wang and
  • Sheng Ma
Pharmaceuticals2025, 18(8), 1241;https://doi.org/10.3390/ph18081241

21 August 2025

Background: Despite advances in prostate cancer treatment, castration-resistant prostate cancer (CRPC) remains clinically challenging due to inherent therapy resistance and a lack of durable alternatives. Although traditional Chinese medicine offers...

Full Article
  • Article
  • Open Access
3 Citations
3,024 Views
29 Pages
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Smart Formulation: AI-Driven Web Platform for Optimization and Stability Prediction of Compounded Pharmaceuticals Using KNIME

  • Artur Grigoryan,
  • Stefan Helfrich,
  • Valentin Lequeux,
  • Benjamine Lapras,
  • Chloé Marchand,
  • Camille Merienne,
  • Fabien Bruno,
  • Roseline Mazet and
  • Fabrice Pirot
Pharmaceuticals2025, 18(8), 1240;https://doi.org/10.3390/ph18081240

21 August 2025

Background/Objectives: Smart Formulation is an artificial intelligence-based platform designed to predict the Beyond Use Dates (BUDs) of compounded oral solid dosage forms. The study aims to develop a decision-support tool for pharmacists by integrat...

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  • Article
  • Open Access
1,117 Views
18 Pages
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VDR Decrease Enhances the Efficacy of 1,25-Dihydroxyvitamin D3 Inhibiting Gefitinib Resistance by Regulating EGFR/FASN Loop in NSCLC Cells

  • Junqing Yang,
  • Mingyu Fang,
  • Mengjun Hou,
  • Yalei Duan,
  • Jiali Wang,
  • Kaiyong Hu,
  • Shuo Liu,
  • Xiaoying Liu,
  • Xiaohan Peng and
  • Zhirong Jia
  • + 1 author
Pharmaceuticals2025, 18(8), 1238;https://doi.org/10.3390/ph18081238

21 August 2025

Background: Gefitinib is a first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) targeting EGFR-mutated non-small cell lung cancer (NSCLC) and is a current first-line treatment for NSCLC. However, acquired resistance...

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  • Article
  • Open Access
1 Citations
1,386 Views
28 Pages
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Multi-Omics and Molecular Docking Studies on Caffeine for Its Skin Rejuvenating Potentials

  • Peng Shu,
  • Nan Zhao,
  • Qi Zhou,
  • Yuan Wang and
  • Lanyue Zhang
Pharmaceuticals2025, 18(8), 1239;https://doi.org/10.3390/ph18081239

21 August 2025

Background: Caffeine (CA) exhibits promising reparative effects against UV-induced skin aging, but the specific mechanisms, including differences in gene and metabolite regulation and the involvement of signaling pathways, are still insufficiently el...

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  • Article
  • Open Access
1,111 Views
24 Pages
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Identification of Potential Pteridin Reductase-1 Inhibitors for the Treatment of Leishmaniasis: A Bioinformatics Approach

  • Paulo R. da S. R. Júnior,
  • Lúcio R. de Lima,
  • Luciane B. Silva,
  • Ryan S. Ramos,
  • Vitor H. da S. Sanches,
  • Njogu M. Kimani,
  • Gustavo H. G. Trossini,
  • Joaquín M. Campos,
  • Cleison C. Lobato and
  • Cleydson B. R. Santos
Pharmaceuticals2025, 18(8), 1237;https://doi.org/10.3390/ph18081237

21 August 2025

Background/Objectives: Leishmaniasis is an infectious disease caused by digenetic protozoa of the genus Leishmania, transmitted by infected female sandflies of the Phlebotominae subfamily. Current treatments are limited, relying on drugs that were no...

Full Article
  • Article
  • Open Access
1,536 Views
18 Pages
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Pharmacologic Potential of Statins in Cancer Prevention: Colo-Rectal Cancer Risk in Dyslipidemic Patients from a Korean Nationwide Cohort

  • Ho Suk Kang,
  • Joo-Hee Kim,
  • Heejin Kim,
  • Joong Seob Lee,
  • Hyo Geun Choi,
  • Dae Myoung Yoo,
  • Kyeong Min Han,
  • Nan Young Kim,
  • Kyueng-Whan Min and
  • Mi Jung Kwon
Pharmaceuticals2025, 18(8), 1236;https://doi.org/10.3390/ph18081236

21 August 2025

Background/Objectives: Colorectal cancer (CRC) is a growing public health concern in South Korea, with incidence rising alongside dyslipidemia. Statins, widely prescribed for lipid control, have been proposed to reduce CRC risk, but evidence remains...

Full Article
  • Systematic Review
  • Open Access
4 Citations
3,987 Views
42 Pages
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Molecular Basis of BRAF Inhibitor Resistance in Melanoma: A Systematic Review

  • Ilaria Cosci,
  • Valentina Salizzato,
  • Paolo Del Fiore,
  • Jacopo Pigozzo,
  • Valentina Guarneri,
  • Simone Mocellin,
  • Alberto Ferlin,
  • Sara Mathlouthi,
  • Luisa Piccin and
  • Mariangela Garofalo
Pharmaceuticals2025, 18(8), 1235;https://doi.org/10.3390/ph18081235

21 August 2025

Background: Melanoma, the deadliest human skin cancer, frequently harbors activating BRAF mutations, with V600E being the most prevalent. These alterations drive constitutive activation of the MAPK pathway, promoting uncontrolled cell proliferation,...

Full Article
  • Comment
  • Open Access
1 Citations
612 Views
4 Pages
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Comment on Somnin et al. Study of Interactions Between Gadolinium-Based Contrast Agents and Collagen by Taylor Dispersion Analysis and Frontal Analysis Continuous Capillary Electrophoresis. Pharmaceuticals 2024, 17, 1633

  • Nicol Guidolin,
  • Federico Maisano,
  • Fabio Tedoldi and
  • Zsolt Baranyai
Pharmaceuticals2025, 18(8), 1233;https://doi.org/10.3390/ph18081233

21 August 2025

With great interest, we read the recent paper published in Pharmaceuticals, titled “Study of Interactions Between Gadolinium-Based Contrast Agents and Collagen by Taylor Dispersion Analysis and Frontal Analysis Continuous Capillary Electrophore...

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  • Article
  • Open Access
2 Citations
950 Views
10 Pages
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Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol

  • Maja Stojković,
  • Djordje S. Marjanović,
  • Dragana Medić,
  • Claude L. Charvet and
  • Saša M. Trailović
Pharmaceuticals2025, 18(8), 1232;https://doi.org/10.3390/ph18081232

20 August 2025

Background: The active ingredients of essential plant oils appear as potentially effective antinematodal drugs or substances that can potentiate the action of already-existing anthelmintics. So far, we have verified that, aside from the direct effect...

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