Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 85
Special Issue Editors
Interests: medicinal chemistry; drug design; drug discovery; heterocyclic compounds; divergent synthesis; antiproliferative agents; antiprotozoal agents; anti-angiogenetic molecules; PDE4 inhibitors
Special Issue Information
Dear Colleagues,
The pyrazole nucleus represents a pivotal building block in a broad range of areas including organic and medicinal chemistry, food industries, and agricultural systems. Furthermore, pyrazole-based compounds have been widely described as pharmaceutically active derivatives endowed with a plethora of biological properties such as anti-inflammatory, anticonvulsant, anticancer, antidepressant, antibacterial, antifungal, analgesic, and antiviral. The pharmacological attractiveness of the pyrazole nucleus is probably due to its particular chemical behavior. In fact, the unshared electrons of the two nitrogen atoms (namely, “pyrrole-like” and “pyridine-like” nitrogens) differently contribute to the resonance of this heterocycle, being uniquely the lone pair of the “pyrrole-like” nitrogen conjugated with the aromatic system. These characteristics allow for the reaction between the nucleus and both acids and bases, making it a perfect building block. Up until now, more than 900 papers have been published in scientific indexed journals and several pyrazole-containing molecules have been approved for clinical applications (e.g., Acomplia®, Celebrex®, Zubrin®, and Xalkori®). Based on this evidence, the current Special Issue aims to enrich the scientific knowledge around the pyrazole scaffold and further support the pharmaceutical interest on pyrazole-based derivatives. This Special Issue will focus on the drug design, synthesis, and biological activity characterization of unreported pyrazole-based molecules with interesting pharmaceutical properties and drug-likeness profile.
We look forward to receiving your contributions.
Dr. Matteo Lusardi
Dr. Marco Ponassi
Guest Editors
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Keywords
- medicinal chemistry
- drug design
- drug discovery
- pyrazole-based compounds
- innovative synthesis
- structure–activity relationships
- biological activities
- drug-like properties
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