Antidiabetic Agents: New Drug Discovery Insights and Prospects
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 May 2026 | Viewed by 7
Special Issue Editor
Interests: medicinal chemistry; drug design and discovery; structure–activity relationships; enzyme inhibitors; antidiabetic agents; anti-inflammatory agents; multitarget agents
Special Issue Information
Dear Colleagues,
Currently, about 10% of the world population suffers from diabetes mellitus (DM), and a dramatic increase in the number of diabetic patients is expected in the coming years. DM is a chronic disease characterized by hyperglycemia, due to tissue insulin resistance and/or insufficient insulin secretion. In the long term, hyperglycemia compromises various cellular functions and causes tissue damage, thus inducing the development of severe complications, such as retinopathy, nephropathy, neuropathies, and cardiovascular pathologies. Therefore, DM is one of the leading causes of death and disability worldwide, and growing attention is required to improve the treatment of this disease over a lifetime, considering the fact that currently available drugs can produce undesired side effects or limited efficacy in some patients. Novel insights into the molecular targets implicated in the complex pathogenesis of DM and its complications prompt drug discovery efforts aimed at the identification of new antidiabetic drugs. Moreover, multitarget agents could provide novel therapeutic options in place of antidiabetic drug combinations. This Special Issue aims to focus on recent advancements and prospects in the design and development of agents for treating DM and its complications. Original research papers, short communications, and review/perspective articles are welcome.
Dr. Rosanna Maccari
Guest Editor
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Keywords
- diabetes mellitus
- drug design
- drug discovery
- drug development
- drug synthesis
- computational-aided drug design
- molecular targets
- biological activity
- structure–activity relationships
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