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Pharmaceuticals
Special Issues
Common Medications Used in Anesthesia
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Common Medications Used in Anesthesia

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 1484

Special Issue Editor

Dr. Michał Jan Stasiowski

E-Mail Website
Guest Editor
Katedra i Zakład Medycyny Stanów Nagłych, Wydział Nauk Medycznych w Zabrzu, Slaski Uniwersytet Medyczny w Katowicach, Katowice, Poland
Interests: anesthesia

Special Issue Information

Dear Colleagues,

This Special Issue on “Common Medications Used in Anesthesia” aims at exploring the latest advancements, challenges, and best practices related to anesthesia medications. It will provide a comprehensive overview of the pharmacological agents commonly utilized in anesthesia practice, including their mechanisms of action, clinical applications, safety profiles, and emerging trends. Through a multidisciplinary approach, this Special Issue will address key topics such as perioperative drug management, anesthetic drug interactions, novel drug developments, and strategies for optimizing patient outcomes. Authors are encouraged to submit original research and review articles that contribute to the understanding and advancement of anesthesia pharmacotherapy.

Dr. Michał Jan Stasiowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anesthesia
  • medications
  • pharmacology
  • perioperative care
  • drug interactions
  • patient safety
  • clinical practice
  • anesthesia management
  • drug development
  • patient outcomes

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Published Papers (1 paper)

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Research

24 pages, 628 KiB  
Article
Adequacy of Anesthesia Guidance for Combined General/Epidural Anesthesia in Patients Undergoing Open Abdominal Infrarenal Aortic Aneurysm Repair; Preliminary Report on Hemodynamic Stability and Pain Perception
by Michał Jan Stasiowski, Seweryn Król, Paweł Wodecki, Nikola Zmarzły and Beniamin Oskar Grabarek
Pharmaceuticals 2024, 17(11), 1497; https://doi.org/10.3390/ph17111497 - 7 Nov 2024
Viewed by 1143
Abstract
Background/Objectives: Hemodynamic instability and inappropriate postoperative pain perception (IPPP) with their consequences constitute an anesthesiological challenge in patients undergoing primary elective open lumbar infrarenal aortic aneurysm repair (OLIAAR) under general anesthesia (GA), as suboptimal administration of intravenous rescue opioid analgesics (IROAs), whose [...] Read more.
Background/Objectives: Hemodynamic instability and inappropriate postoperative pain perception (IPPP) with their consequences constitute an anesthesiological challenge in patients undergoing primary elective open lumbar infrarenal aortic aneurysm repair (OLIAAR) under general anesthesia (GA), as suboptimal administration of intravenous rescue opioid analgesics (IROAs), whose titration is optimized by Adequacy of Anaesthesia (AoA) guidance, constitutes a risk of adverse events. Intravenous or thoracic epidural anesthesia (TEA) techniques of preventive analgesia have been added to GA to minimize these adverse events. Methods: Seventy-five patients undergoing OLIAAR were randomly assigned to receive TEA with 0.2% ropivacaine (RPV) with fentanyl (FNT) 2.5 μg/mL (RPV group) or 0.2% bupivacaine (BPV) with FNT 2.5 μg/mL (BPV group) or intravenous metamizole/tramadol (MT group). IROA using FNT during GA was administered under AoA guidance. Systemic morphine was administered as a rescue agent in all groups postoperatively in the case of IPPP, assessed using the Numeric Pain Rating Score > 3. The maximum score at admission and the minimum at discharge from the postoperative care unit to the Department of Vascular Surgery, perioperative hemodynamic stability, and demand for rescue opioid analgesia were analyzed. Results: Ultimately, 57 patients were analyzed. In 49% of patients undergoing OLIAAR, preventive analgesia did not prevent the incidence of IPPP, which was not statistically significant between groups. No case of acute postoperative pain perception was noted in the RPV group, but at the cost of statistically significant minimum mean arterial pressure values, reflecting hemodynamic instability, with clinical significance < 65mmHg. Demand for postoperative morphine was not statistically significantly different between groups, contrary to significantly lower doses of IROA using FNT in patients receiving TEA. Conclusions: AoA guidance for IROA administration with FNT blunted the preventive analgesia effect of TEA compared with intravenous MT that ensured proper perioperative hemodynamic stability along with adequate postoperative pain control with acceptable demand for postoperative morphine. Full article
(This article belongs to the Special Issue Common Medications Used in Anesthesia)
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