Green Synthesis and Biological Evaluation of Nitrogen-Containing Heterocycles
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (25 June 2026) | Viewed by 2897
Editors
Interests: deep eutectic solvents; quinazolinones; coumarins; microwave-assisted synthesis; mechanochemical synthesis; green chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: organic synthesis; green chemistry; medicinal chemistry; quinazolinones; glycoconjugates; ligand–receptor interactions
Special Issues, Collections and Topics in MDPI journals
Interests: deep eutectic solvents; quinazolinones; coumarins; microwave-assisted synthesis; mechanochemical synthesis; green chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The conventional synthesis of different heterocycles often involves the use of volatile organic solvents, catalysts, and high energy consumption, leading to the accumulation of large amounts of waste. In recent decades, green synthesis has utilized safer solvents, such as deep eutectic solvents and biomass-derived solvents, instead of harmful organic solvents. Due to their favorable properties, these solvents, combined with green synthetic methods, can reduce or eliminate waste production, making synthesis cleaner and faster. Nitrogen-containing (N-containing) heterocycles represent a class of compounds with a broad spectrum of biological activities, attributed to their interactions with various biological targets. Their potential in drug discovery continues to grow, highlighting the importance of preparing novel derivatives that may serve as candidates for the development of new therapeutic agents. This Special Issue highlights recent advances in the green synthesis of N-containing heterocycles—five membered, six-membered, and fused-ring systems. Furthermore, we welcome submissions that cover biological activities, including antimicrobial, antiproliferative, antiradical, and anti-inflammatory activities, amongst others. Their potential activities can be predicted by computational studies. Therefore, both the synthesis and biological evaluation of N-containing compounds are welcomed as topics in this Special Issue. We will take both research papers and reviews into consideration for publication.
Dr. Mario Komar
Dr. Marija Paurević
Dr. Maja Molnar
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- N-containing heterocycles
- microwave-assisted synthesis
- ultrasound-assisted synthesis
- mechanochemical synthesis
- deep eutectic solvents
- biomass-derived solvents
- biological evaluation
- computational methods
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