Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 717
Special Issue Editors
Interests: drug design and synthesis; medicinal chemistry; organic synthesis; antimicrobial agents; structure–activity relationship; antiviral agents; antiparasitic agents; anticancer agents; antiprotozoal agents
Special Issues, Collections and Topics in MDPI journals
Interests: synthesis of heterocycles; medicinal chemistry; organic chemistry; medicinal chemistry and drug design; medicinal chemistry CNS drug discovery and delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Most of the organic compounds used as therapeutics, as well as intermediates utilized for their synthesis, contain heterocyclic motifs. A heterocycle is a ring with at least one atom that is not carbon. Nitrogen, oxygen, and sulfur are the primary elements seen in common heterocycles, and they play a critical role in drug discovery. Furthermore, there are a plethora of natural products which are heterocycles that serve as the basis for many different substances, including alkaloids, vitamins, hormones, dyes, antibiotics, herbicides, or nutraceuticals. Over the past decades, much attention has been devoted to the development and pharmacological studies of heteroaromatic organic compounds that are currently considered privileged scaffolds for different therapeutic agents. Indeed, they are involved in a wide range of biological activities, representing nearly 60% of all FDA-approved drugs. This Special Issue will publish research papers with topics including, but not limited to, the preparation of aromatic and non-aromatic heterocycles endowed with any biological action. We also welcome contributions that highlight the importance of heterocyclic scaffolds that are widely found in agrochemicals, dyes, cosmetics, and functional materials. The aim of the present Special Issue is primarily to present an overview of the state-of-the-art synthetic methods and recent advances in the synthesis of heterocycles.
This Special Issue is dedicated to the memory of our dearest colleague and friend, Dr. Luca Pescatori, whose entire life, unjustly interrupted prematurely, was devoted not only to the scientific career in the field of medicinal chemistry, but certainly also at cheering up the existence of all those who had the honor of being by his side.
Dr. Valentina Noemi Madia
Dr. Davide Ialongo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heterocycles
- drug design
- drug discovery
- bioactive compounds
- structure-based drug design
- structure–activity relationship
- in silico studies
- ADMET properties
- multicomponent reactions
- phytochemicals
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