Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 39
Special Issue Editors
Interests: design and synthesis of novel anti-inflammatory and anticancer agents; in silico drug design and molecular modelling; development of new synthetic methodologies; biophysical and biochemical assay applications; isolation and characterization of natural products with biological activity
Interests: drug discovery; bioactive compounds; small molecules; anticancer activity; medicinal chemistry; synthesis; structure–activity relationships; anti-inflammatory agents; mPGES-1 inhibitors; prostaglandin E2 biosynthesis; epigenetic drugs; BRD9; JMJD3 inhibitors; erbB4 inhibitors
Special Issue Information
Dear Colleagues,
Heterocyclic compounds have been extensively studied over the years, revealing a broad spectrum of biological activities, including anticancer, antimicrobial, and anti-inflammatory effects. This has led to the development of the concept of "Privileged Scaffolds", which refers to chemical structures capable of binding to multiple biological targets with high affinity, achieving selectivity through strategic functional modifications. Thanks to their favorable pharmacological profiles, these scaffolds are widely employed in the rational design of therapeutics and are present in numerous clinically approved anticancer and/or anti-inflammatory agents. The aim of this Special Issue is to provide an up-to-date overview of recent advances in the application of privileged heterocyclic scaffolds in the development of targeted anticancer and/or anti-inflammatory drugs. Manuscripts, whether original research or comprehensive reviews, should focus on scaffolds demonstrating significant activity against specific oncotargets or inflammatory pathways. Original research articles and review papers addressing either the anticancer potential or the anti-inflammatory activity of selective molecular scaffolds are warmly invited.
Dr. Ester Colarusso
Dr. Assunta Giordano
Guest Editors
Manuscript Submission Information
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Keywords
- drug discovery
- medicinal chemistry
- privileged scaffolds
- heterocyclic compounds
- anticancer activity
- anti-inflammatory activity
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