Treatment and Molecular Mechanisms of Depression
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 1137
Special Issue Editors
Interests: psychiatric disorders; psychopharmacology; medicinal plants; active compounds; molecular biology
Special Issue Information
Dear Colleagues,
Research has been advancing in the understanding of the molecular mechanisms involved in major depressive disorder (MDD), which may be targets for more effective pharmacological strategies. In addition to the neurotransmission mechanisms that have been evidenced for some time, biological mechanisms, such as epigenetics, inflammation, and neuroinflammation, intracellular signaling, genetic polymorphisms, hypothalamic-pituitary-adrenal (HPA) axis function, among others, have been gaining scientific attention as biological targets for possible new drugs or other therapeutic strategies.
This special issue aims to provide articles addressing molecular biological aspects underlying MDD and new drugs or treatment strategies that may target the molecular mechanisms, constituting more effective approaches for treating MDD and treatment-resistant depression (TRD).
Original research articles and reviews are welcome in this special issue. Research areas may include (but are not limited to) the following: studies with neurotransmitters, receptors and their mechanisms of action, epigenetic mechanisms, molecular mechanisms of inflammation and neuroinflammation, genetic polymorphisms, and mechanisms involved in oxidative balance. Studies with new drugs or pharmacological strategies that target the most diverse molecular mechanisms will also be welcome.
Dr. Zuleide Maria Ignácio
Dr. Ricieri Mocelin
Guest Editors
Manuscript Submission Information
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Keywords
- major depressive disorder
- molecular mechanisms
- neurotransmitters
- epigenetic
- genetic polymorphisms
- inflammation
- neuroinflammation
- pharmacological strategies
- drugs
- intracellular signaling
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