Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 28
Special Issue Editors
Interests: organic chemistry; heterocycle synthesis; isoxazole; oxazolo[5,4-d]pyrimdine; spectra analysis; anticancer agents; biological activity
Interests: medicinal chemistry; hydrazones; oxadiazoles; triazoles; pro-apoptotic drugs; COX inhibitors; isothiazoles; Schiff-base; anticancer agents design and synthesis; tyrosine kinase inhibitors
Interests: intermolecular interactions; drug design; molecular modeling; molecular docking; protein conformation; protein binding
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery and development of targeted small-molecule agents for the treatment of solid cancers is of particular interest for three main reasons. Firstly, it is important to note that solid tumors, defined as an abnormal mass of tissue, represent the most frequently diagnosed types of cancers worldwide each year. Secondly, conventional chemotherapy with cytostatic drugs does not demonstrate selective anticancer activity, which consequently results in numerous side effects. Finally, the development of resistance to the known drugs and the unsatisfactory treatment results are challenges that persist and warrant significant attention. The progress in the characterization of the solid cancers provide an identification of new molecular targets and genetic alterations involved in tumor growth. These findings correspond to an increase in the number of effective targeted therapies used in the treatment of solid cancers.
This Special Issue, entitled “Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors”, will present research that investigates the design, synthesis, and molecular mechanism of the action of novel anticancer agents. The aim of this Special Issue is to emphasize trends in the discovery of new chemical entities and molecular targets in the treatment of solid cancers. We welcome contributions on reviews or original research articles.
Dr. Aleksandra Sochacka-Ćwikła
Dr. Małgorzata Strzelecka
Dr. Żaneta Czyżnikowska
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- anticancer drugs
- small-molecule agents
- targeted therapy
- solid cancers
- drug delivery systems
- drug resistance
- approval characteristic
- FDA
- EMA
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
