Targeting Bacterial Metabolism with Natural and Synthetic Inhibitors
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 14
Special Issue Editors
Interests: adenylate kinase; enzymatic inhibitors; antibiotic resistance; natural products
Special Issues, Collections and Topics in MDPI journals
Interests: computational chemistry; drug discovery; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: antibiotics discovery; anticancerous drugs discovery; medicinal chemistry; organic synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on inhibitors that target bacterial metabolism and are used to explore the metabolic pathways of prokaryotic cells. We aim to analyze natural and synthetic compounds that target the same metabolic pathway via comparative studies.
The increasing prevalence of multi-drug resistant bacterial strains has intensified research efforts into finding new inhibitors to manage human infections, especially in treating nosocomial infections, which particularly affect immunosuppressed individuals. It is particularly pertinent to explore other suitable targets, such as enzymes involved in different metabolic pathways.
Computational tools offer significant progress in screening large numbers of compounds to identify the most suitable ones for further study. The synthesis of new inhibitors can be time-consuming; therefore, carefully selecting potentially effective compounds is vital. Moreover, the differences between eukaryotic and prokaryotic metabolic pathways enable further toxicity studies. Testing inhibitors is a means to demonstrate their efficacy, advancing their use in therapy. In addition, the variety of natural resources across different environments provides an abundance of natural compounds, which can be selected and used alone or in combination to target specific metabolic pathways.
In this Special Issue, we seek research articles and reviews that present innovative findings
that advance our knowledge of inhibitors of bacterial metabolism.
Dr. Mihaela Ileana Ionescu
Dr. Cristina Nastasă
Prof. Dr. Ovidiu Oniga
Guest Editors
Manuscript Submission Information
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Keywords
- bacterial metabolism
- protein kinases
- therapeutic strategy
- clinical studies
- natural inhibitors
- enzymatic activity
- drug design
- structural studies
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