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Life
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Research Progress in Kidney Diseases
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Research Progress in Kidney Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 1183

Special Issue Editor

Dr. Ane Claudia Fernandes Nunes

E-Mail Website
Guest Editor
Department of Medicine, Division of Nephrology, University of California, Irvine, CA, USA
Interests: cerebral microhemorrhages
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney diseases (KDs) are known worldwide from the bench to the bedside, but they are a hard theme to approach with one single point of view. In this sense, a selection of translational studies would support the medical science community to better understand the complex network of the renal failure process, its management, and potential treatment targets. This Special Issue will offer a comprehensive overview of chronic kidney disease (CKD) and acute kidney injury (AKI). It will include many areas in nephrology research and its correlated fields, such clinical parameters and biomarkers, molecular biology applied to KD diagnosis, and basic research on and innovation in nephrology. Manuscripts should address such topics as cardiovascular disease in CKD patients, diabetes, kidney disease, palliative care in CKD, biochemical tests for evaluation and prognostics in CKD, renal replacement therapies, and artificial intelligence (AI) applied to clinical routines. Hemodialysis and treatment advances in renal replacement therapy (RRT) used to replace the capacity of blood filtration, which is completely lost in end-stage renal disease (ESRD), are also welcome in this Special Issue.

Dr. Ane Claudia Fernandes Nunes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • acute kidney injury
  • hemodialysis
  • nephrology
  • renal failure
  • hypertension
  • diabetes
  • molecular genetics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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13 pages, 2924 KiB  
Case Report
Stereotactic Ablative Radiotherapy for Delayed Retrobulbar Metastasis of Renal Cell Carcinoma: Therapeutic Outcomes and Practical Insights
by Sang Jun Byun, Byung Hoon Kim, Seung Gyu Park and Euncheol Choi
Life 2025, 15(8), 1176; https://doi.org/10.3390/life15081176 - 24 Jul 2025
Viewed by 365
Abstract
We present a rare case of delayed retrobulbar and adrenal metastases from renal cell carcinoma (RCC), diagnosed 5.5 years after radical nephrectomy. The patient exhibited symptomatic orbital involvement, with imaging revealing a hypervascular retrobulbar mass and an incidental right adrenal lesion, indicative of [...] Read more.
We present a rare case of delayed retrobulbar and adrenal metastases from renal cell carcinoma (RCC), diagnosed 5.5 years after radical nephrectomy. The patient exhibited symptomatic orbital involvement, with imaging revealing a hypervascular retrobulbar mass and an incidental right adrenal lesion, indicative of an oligometastatic state. Owing to the patient’s refusal of surgical resection, stereotactic ablative radiotherapy (SABR) was delivered to the retrobulbar lesion at a total dose of 40 Gy in five fractions, concurrently with immune checkpoint inhibitor therapy. Treatment planning prioritized sparing adjacent critical structures, including the optic chiasm and brainstem. Follow-up over 4 years demonstrated sustained radiologic stability and volume reduction in both metastatic lesions without evidence of progression. This case underscores the potential efficacy of SABR in achieving durable local control of RCC metastases, particularly in anatomically constrained regions where surgery is unfeasible. Moreover, it highlights the value of a multidisciplinary, multimodal treatment approach incorporating advanced radiotherapy techniques and systemic immunotherapy. Lastly, it reinforces the importance of prolonged surveillance in RCC survivors due to the potential for late metastatic recurrence at uncommon sites. Full article
(This article belongs to the Special Issue Research Progress in Kidney Diseases)
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19 pages, 764 KiB  
Systematic Review
Outcomes of Acute Kidney Injury in Melioidosis: A Systematic Review and Meta-Analysis
by Wiyada Kwanhian Klangbud, Moragot Chatatikun, Sa-ngob Laklaeng, Jitabanjong Tangpong, Pakpoom Wongyikul, Phichayut Phinyo, Jongkonnee Thanasai, Supphachoke Khemla, Chaimongkhon Chanthot and Atthaphong Phongphithakchai
Life 2025, 15(7), 1108; https://doi.org/10.3390/life15071108 - 15 Jul 2025
Viewed by 423
Abstract
Background: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, with high mortality rates, particularly in severe cases complicated by acute kidney injury (AKI). Objective: The objective of this study was to systematically review and quantitatively synthesize the impact of AKI [...] Read more.
Background: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, with high mortality rates, particularly in severe cases complicated by acute kidney injury (AKI). Objective: The objective of this study was to systematically review and quantitatively synthesize the impact of AKI on mortality and other clinical outcomes—including ICU admission and the need for renal replacement therapy (RRT)—in patients with melioidosis. Methods: A systematic search was conducted in PubMed, Scopus, and Embase up to 16 May 2025. Studies reporting mortality, ICU admission, or RRT use in patients with AKI were included. A random-effects meta-analysis was performed to estimate the odds ratio (OR) for mortality associated with AKI. Results: Twenty-nine studies (380 patients) were included. AKI occurred in 123 patients (32.4%). The pooled analysis revealed that AKI patients had a significantly higher mortality risk than non-AKI patients (OR = 23.37; 95% CI: 13.97–39.10; p = 0.0082), with no significant heterogeneity (I2 = 0%). Sensitivity analysis confirmed the robustness of this association. ICU admission and RRT data were frequently reported but were not suitable for meta-analysis due to insufficient data. Conclusions: AKI is a serious complication in melioidosis, significantly increasing the risk of mortality. Early recognition and aggressive management of AKI in melioidosis may be critical to improving clinical outcomes. Full article
(This article belongs to the Special Issue Research Progress in Kidney Diseases)
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