Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Body Fluid-Based Biomarkers for Cognitive Impairment
edited by Wei Li
submission deadline 24 Apr 2026 | Viewed by 434 | Submission Open
Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis
(This special issue belongs to the Section Medical Research)
The Impact of Onconutraceutics as Potential Oncological Strategy submission deadline 24 Apr 2026 | Viewed by 103 | Submission Open
Keywords: nutraceuticals; oncological therapies; onconutraceuticals; molecular pathways modulated by onconutraceuticals; chemotherapy; radiotherapy; personalized therapies; non-invasive approaches
(This special issue belongs to the Section Physiology and Pathology)
The 15th Anniversary of Life: Endothelial Glycocalyx—A Determinant of Endothelial Function and Vascular Reactivity submission deadline 24 Apr 2026 | Viewed by 70 | Submission Open
Keywords: endothelial glycocalyx; cardiovascular system; oxidative stress; inflammation; nutrition
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Phytohormones
edited by
submission deadline 25 Apr 2026 | Viewed by 128 | Submission Open
Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses
(This special issue belongs to the Section Plant Science)
Recent Trends in Prebiotic Chemistry
edited by Maheen Gull
submission deadline 26 Apr 2026 | Viewed by 431 | Submission Open
Keywords: early earth; prebiotic chemistry; meteorites; molecules of life; phosphorylation; challenges in prebiotic chemistry; chirality; condensation; wet– dry cycles; RNA world; hydrothermal systems; mineral catalysis
(This special issue belongs to the Section Origin of Life)
Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology submission deadline 27 Apr 2026 | Viewed by 304 | Submission Open
Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems
(This special issue belongs to the Section Pharmaceutical Science)
Gynecological Cancer: Etiologic, Diagnostic, Prognostic, and Therapeutic Research submission deadline 27 Apr 2026 | Viewed by 238 | Submission Open
Keywords: gynecological cancer; chemotherapy in gynecological cancers; radiation therapy in gynecological oncology; gynecological cancer biomarkers; cancer prevention; gynecological cancer immunotherapy
(This special issue belongs to the Section Medical Research)
Clinical Update for Resuscitation Science: 2nd Edition
edited by Mitsuaki Nishikimi
submission deadline 27 Apr 2026 | Viewed by 76 | Submission Open
Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma
(This special issue belongs to the Section Medical Research)
Life in Space: From Molecules to Extremophiles
edited by Alessia Cassaro and
submission deadline 27 Apr 2026 | Viewed by 65 | Submission Open
Keywords: astrobiology; life in space; extreme environments; extremophiles; adaptation mechanisms; ground-based simulation; planetary protection; life detection strategies; spaceflight experiments; synthetic biology
(This special issue belongs to the Section Astrobiology)
Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments
edited by Pedro Caravaca-Pérez and Jose Jesus Broseta
submission deadline 28 Apr 2026 | 2 articles | Viewed by 1541 | Submission Open
Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment
(This special issue belongs to the Section Medical Research)
New Developments in Mycology submission deadline 28 Apr 2026 | 1 articles | Viewed by 850 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
Neurodegenerative Diseases: From Risk Factors to Treatments
edited by
submission deadline 28 Apr 2026 | Viewed by 127 | Submission Open
Keywords: immune regulation (e.g.; chronic inflammation) of NDs; cardiocerebral vascular disease and NDs; the effects of emotional and affective dimensions on cognitive reserve decline; the multidimensional screening of NDs; the interventions of NDs; gene polymorphism on the efficacy of pharmacological treatments in NDs; cognitive and functional rehabilitation for patients with NDs; technology innovation in the integrated approach to the patients with NDs
(This special issue belongs to the Section Medical Research)
Reviewing the Landscape of Psychopharmacology
edited by
submission deadline 28 Apr 2026 | Viewed by 88 | Submission Open
Keywords: psychopharmacology; mood disorders; neurobiology; drug safety; translational psychiatry
(This special issue belongs to the Section Pharmaceutical Science)
Carbon and Nitrogen Cycles in Terrestrial Ecosystems
edited by
submission deadline 29 Apr 2026 | 4 articles | Viewed by 6435 | Submission Open
Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles
(This special issue belongs to the Section Diversity and Ecology)
Cardiovascular–Kidney–Metabolic (CKM) Syndrome
edited by Chien Yu Lin and
submission deadline 30 Apr 2026 | 3 articles | Viewed by 9479 | Submission Open
Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM
(This special issue belongs to the Section Medical Research)
Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 3 articles | Viewed by 8900 | Submission Open
Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments
(This special issue belongs to the Section Physiology and Pathology)
Advanced Heart Failure and Transplant Cardiology
edited by David Dobarro
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2912 | Submission Open
Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices
(This special issue belongs to the Section Medical Research)
Kidney Transplantation: What’s Hot and What’s New—2nd Edition
edited by and Caterina Di Bella
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1987 | Submission Open
Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation
(This special issue belongs to the Section Medical Research)
From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1296 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Physiology and Pathology)
Minimally Invasive Neuroendoscopy
edited by Stefan Linsler
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1269 | Submission Open
Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy
(This special issue belongs to the Section Medical Research)
An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 1 articles | Viewed by 846 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Medical Research)
Multi-Omics Insights into Traditional Fermented Foods: Microbial Ecology, Metabolite Profiles, and Functional Applications
edited by , Lan-Szu Chou, Chih-Yu Lo and
submission deadline 30 Apr 2026 | Viewed by 154 | Submission Open
Keywords: traditional fermented foods; omics analysis; fermentation biotechnology; bioactive metabolites
(This special issue belongs to the Section Microbiology)
Advances in Binocular Vision Assessment and Management: From Anomalies to Oculomotor Norms submission deadline 30 Apr 2026 | Viewed by 138 | Submission Open
Keywords: binocular vision; oculomotor control vergence; accommodation; strabismus; amblyopia; convergence insufficiency; eye-tracking; visual rehabilitation; normative oculomotor behavior
(This special issue belongs to the Section Medical Research)
Phytochemicals in Focus: Bioactivity, Safety, and Therapeutic Potential
edited by Naeem Khan
submission deadline 30 Apr 2026 | Viewed by 133 | Submission Open
Keywords: phytochemicals; antioxidant activity; antimicrobial properties; toxicity evaluation; natural products; medicinal plants and bioactivity; oxidative stress plant extracts; therapeutic potential; safety assessment; bioactive compounds
(This special issue belongs to the Section Plant Science)
Rumen Microbiome and Fermentation Function Research
edited by
submission deadline 30 Apr 2026 | Viewed by 124 | Submission Open
Keywords: rumen; in vivo; in vitro; microbe; fermentation; multi-omics
(This special issue belongs to the Section Animal Science)
Updates in Pancreas and Colorectal Adenocarcinoma
edited by
submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open
Keywords: pancreatic and colorectal carcinoma; pancreatic cancer; colorectal cancer
(This special issue belongs to the Section Medical Research)
Behavioral Manifestations and Neural Regulation of Movements submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open
Keywords: motor control; movement behavior; sensorimotor integration; neurophysiology; emotion and movement; cognitive-motor interaction; temperament; neurotechnology; rehabilitation; performance
(This special issue belongs to the Section Physiology and Pathology)
15th Anniversary of Life—Emerging Plant-Based Materials and Bioactive Compounds in Biomedical Applications
edited by
submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open
Keywords: plant-derived materials; bioactive compounds; phytochemicals; biomedical applications; natural products; plant-based polymers; drug delivery; tissue engineering
(This special issue belongs to the Section Plant Science)
Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open
Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease
Cortical Development and Neurotransmission
edited by Christine Hohmann and Joanne Berger-Sweeney
submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open
Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism
(This special issue belongs to the Section Medical Research)
Developmental Programming in Cats and Dogs
edited by , and Sylvie Chastant
submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering
(This special issue belongs to the Section Animal Science)
Advances in Sustainable Animal Nutrition: Impacts on Physiology, Health, and Production submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: animal nutrition; alternative feedstuffs; physiology; gut health; nutrient metabolism; immune function; animal performance; sustainable livestock production
(This special issue belongs to the Section Animal Science)
Novel Diagnostics and Therapeutics for Ophthalmic Diseases
edited by
submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open
Keywords: clinical ophthalmology; ophthalmic innovations; diagnostic technologies; therapeutic advancements; surgical techniques; disparity in global eye health; personalized medicine
(This special issue belongs to the Section Medical Research)
Genetic Drivers in Endocrine Disorders: From Rare Variants to Aggressive Malignancies submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open
Keywords: endocrine tumors; rare variants; somatic variants; next-generation sequencing; molecular pathology; differentially expressed genes; aggressive tumor phenotype; novel genetic tests
(This special issue belongs to the Section Genetics and Genomics)
Research and Management of Endocrine Tumors submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open
Keywords: thyroid cancer; papillary thyroid cancer; anaplastic thyroid cancer; radioiodine; multiple kinase and angiogenetic factor inhibitors; adrenal cancer; pituitary adenomas
(This special issue belongs to the Section Medical Research)
Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome
edited by Gwo-Ping Jong
submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; coronary artery disease; endothelial dysfunction; stroke; hypertension; peripheric arterial disease; metabolic dysfunction; hyperlipidemia
(This special issue belongs to the Section Physiology and Pathology)
Research and Management in Autoimmune Rheumatic Diseases submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: autoimmune rheumatic diseases; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; Sjogren's syndrome; biologic agents; JAK inhibitors
(This special issue belongs to the Section Medical Research)
Targeting DEK and TGF-β Signaling in Gynecologic Disease and Cancer: Diagnostic and Therapeutic Perspectives
edited by and Anastasia Tsigkou
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: DEK oncogene; TGF-β signaling; cervical cancer; endometriosis; uterine myomas; cancer biomarkers; epithelial– mesenchymal transition (EMT); SMAD2/3 phosphorylation; LY364947; targeted therapy
(This special issue belongs to the Section Medical Research)
Advances in Disease Mechanisms and Treatment Innovations in Rhinology and Allergy
edited by
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: sinonasal disorder  ; chronic rhinosinusitis  ; rhinitis  ; empty nose syndrome  ; nasal septal deviation  ; obstructive sleep apnea  ; sinonasal tumor  ; skull base surgery  ; pediatric otorhinolaryngology
(This special issue belongs to the Section Medical Research)
Advanced Research in Plant Physiology, Metabolism and Signal Transduction
edited by Xiaomin Wang
submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open
Keywords: plant development; plant– environment interaction; plant– microbe interactions; signaling transduction; stress adaptation
(This special issue belongs to the Section Plant Science)
Advances on Tissue Engineering in Reproduction submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open
Keywords: translational regenerative medicine; bioengineered scaffolds; organoids and organ-on-a-chip; in vitro models; extracellular matrix on reproduction and regeneration
(This special issue belongs to the Section Animal Science)
Decoding Helicobacter pylori: Genetic Secrets, Flagellar Motility, and Biofilm Mechanisms
edited by Xiaolin Liu and Shuai Hu
submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open
Keywords: virulence genes; motility; flagella; biofilm; antibiotic resistance; colonization; Helicobacter pylori
(This special issue belongs to the Section Microbiology)
Novel Biomarkers for Lymphoma Diagnosis and Prognosis: Translating Research into Practice
edited by Dominic Kaddu-Mulindwa
submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open
Keywords: lymphoma; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); molecular profiling; tumor microenvironment; epigenetic markers; predictive diagnostics
(This special issue belongs to the Section Physiology and Pathology)
Breakthroughs in Radiotherapy for Cancer submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open
Keywords: radiotherapy; radioimmunotherapy; AI-enhanced radiotherapy; bio-guided radiotherapy
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Diabetes, Microbiome, and Inflammation: Mechanisms and Therapeutic Perspectives submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open
Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis
(This special issue belongs to the Section Medical Research)
Current Challenges in Prognostic Assessment and Intervention Strategies in Acute and Critical Care
edited by
submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open
Keywords: acute and critical care; prognostic assessment; biomarkers; therapeutic strategies; sepsis; trauma; cardiac arrest; respiratory failure/ARDS; neurocritical care; implementation; patient-centered outcomes keyword
(This special issue belongs to the Section Medical Research)
Ultrasound-Guided Interventions and Advances in Musculoskeletal Disorders
edited by Chih-Ya Chang
submission deadline 5 May 2026 | Viewed by 30 | Submission Open
Keywords: ultrasound-guided interventions; regenerative medicine; platelet-rich plasma (PRP); musculoskeletal disorders; shoulder and knee osteoarthritis; peripheral nerve injuries
(This special issue belongs to the Section Medical Research)
Exploration of Gene Regulation and Therapeutic Targets in Refractory Cancers
edited by Wei-Chieh Huang
submission deadline 6 May 2026 | Viewed by 37 | Submission Open
Keywords: refractory cancers; gene regulation; targeted therapy; drug resistance
(This special issue belongs to the Section Medical Research)
Melatonin Signaling: Therapeutic Implications and Molecular Mechanisms submission deadline 15 May 2026 | Viewed by 306 | Submission Open
Keywords: melatonin; AANAT; HIOMT; MTNR1A; MTNR1B; circadian rhythms
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Crop Genetics and Breeding: 2nd Edition
edited by , , and Long Chen
submission deadline 15 May 2026 | Viewed by 45 | Submission Open
Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection
(This special issue belongs to the Section Plant Science)
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