Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Research on Phytohormones
edited by
submission deadline 25 Apr 2026 | Viewed by 133 | Submission Open
Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses
(This special issue belongs to the Section Plant Science)
Recent Trends in Prebiotic Chemistry
edited by Maheen Gull
submission deadline 26 Apr 2026 | Viewed by 436 | Submission Open
Keywords: early earth; prebiotic chemistry; meteorites; molecules of life; phosphorylation; challenges in prebiotic chemistry; chirality; condensation; wet– dry cycles; RNA world; hydrothermal systems; mineral catalysis
(This special issue belongs to the Section Origin of Life)
Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology submission deadline 27 Apr 2026 | Viewed by 305 | Submission Open
Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems
(This special issue belongs to the Section Pharmaceutical Science)
Gynecological Cancer: Etiologic, Diagnostic, Prognostic, and Therapeutic Research submission deadline 27 Apr 2026 | Viewed by 239 | Submission Open
Keywords: gynecological cancer; chemotherapy in gynecological cancers; radiation therapy in gynecological oncology; gynecological cancer biomarkers; cancer prevention; gynecological cancer immunotherapy
(This special issue belongs to the Section Medical Research)
Clinical Update for Resuscitation Science: 2nd Edition
edited by Mitsuaki Nishikimi
submission deadline 27 Apr 2026 | Viewed by 80 | Submission Open
Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma
(This special issue belongs to the Section Medical Research)
Life in Space: From Molecules to Extremophiles
edited by Alessia Cassaro and
submission deadline 27 Apr 2026 | Viewed by 67 | Submission Open
Keywords: astrobiology; life in space; extreme environments; extremophiles; adaptation mechanisms; ground-based simulation; planetary protection; life detection strategies; spaceflight experiments; synthetic biology
(This special issue belongs to the Section Astrobiology)
Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments
edited by Pedro Caravaca-Pérez and Jose Jesus Broseta
submission deadline 28 Apr 2026 | 3 articles | Viewed by 1616 | Submission Open
Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment
(This special issue belongs to the Section Medical Research)
New Developments in Mycology submission deadline 28 Apr 2026 | 1 articles | Viewed by 871 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
Neurodegenerative Diseases: From Risk Factors to Treatments
edited by
submission deadline 28 Apr 2026 | Viewed by 129 | Submission Open
Keywords: immune regulation (e.g.; chronic inflammation) of NDs; cardiocerebral vascular disease and NDs; the effects of emotional and affective dimensions on cognitive reserve decline; the multidimensional screening of NDs; the interventions of NDs; gene polymorphism on the efficacy of pharmacological treatments in NDs; cognitive and functional rehabilitation for patients with NDs; technology innovation in the integrated approach to the patients with NDs
(This special issue belongs to the Section Medical Research)
Reviewing the Landscape of Psychopharmacology
edited by
submission deadline 28 Apr 2026 | Viewed by 88 | Submission Open
Keywords: psychopharmacology; mood disorders; neurobiology; drug safety; translational psychiatry
(This special issue belongs to the Section Pharmaceutical Science)
Carbon and Nitrogen Cycles in Terrestrial Ecosystems
edited by
submission deadline 29 Apr 2026 | 4 articles | Viewed by 6558 | Submission Open
Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles
(This special issue belongs to the Section Diversity and Ecology)
Cardiovascular–Kidney–Metabolic (CKM) Syndrome
edited by Chien Yu Lin and
submission deadline 30 Apr 2026 | 3 articles | Viewed by 9674 | Submission Open
Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM
(This special issue belongs to the Section Medical Research)
Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 3 articles | Viewed by 9171 | Submission Open
Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments
(This special issue belongs to the Section Physiology and Pathology)
Health Management of Farm Animals: Physiological and Pathological Aspects submission deadline 30 Apr 2026 | 3 articles | Viewed by 3148 | Submission Open
Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare
(This special issue belongs to the Section Animal Science)
Advanced Heart Failure and Transplant Cardiology
edited by David Dobarro
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2948 | Submission Open
Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices
(This special issue belongs to the Section Medical Research)
Kidney Transplantation: What’s Hot and What’s New—2nd Edition
edited by and Caterina Di Bella
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2033 | Submission Open
Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation
(This special issue belongs to the Section Medical Research)
From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1544 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Physiology and Pathology)
Minimally Invasive Neuroendoscopy
edited by Stefan Linsler
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1282 | Submission Open
Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy
(This special issue belongs to the Section Medical Research)
An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 1 articles | Viewed by 880 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Medical Research)
Multi-Omics Insights into Traditional Fermented Foods: Microbial Ecology, Metabolite Profiles, and Functional Applications
edited by , Lan-Szu Chou, Chih-Yu Lo and
submission deadline 30 Apr 2026 | Viewed by 157 | Submission Open
Keywords: traditional fermented foods; omics analysis; fermentation biotechnology; bioactive metabolites
(This special issue belongs to the Section Microbiology)
Advances in Binocular Vision Assessment and Management: From Anomalies to Oculomotor Norms submission deadline 30 Apr 2026 | Viewed by 149 | Submission Open
Keywords: binocular vision; oculomotor control vergence; accommodation; strabismus; amblyopia; convergence insufficiency; eye-tracking; visual rehabilitation; normative oculomotor behavior
(This special issue belongs to the Section Medical Research)
Phytochemicals in Focus: Bioactivity, Safety, and Therapeutic Potential
edited by Naeem Khan
submission deadline 30 Apr 2026 | Viewed by 140 | Submission Open
Keywords: phytochemicals; antioxidant activity; antimicrobial properties; toxicity evaluation; natural products; medicinal plants and bioactivity; oxidative stress plant extracts; therapeutic potential; safety assessment; bioactive compounds
(This special issue belongs to the Section Plant Science)
Rumen Microbiome and Fermentation Function Research
edited by
submission deadline 30 Apr 2026 | Viewed by 130 | Submission Open
Keywords: rumen; in vivo; in vitro; microbe; fermentation; multi-omics
(This special issue belongs to the Section Animal Science)
Updates in Pancreas and Colorectal Adenocarcinoma
edited by
submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open
Keywords: pancreatic and colorectal carcinoma; pancreatic cancer; colorectal cancer
(This special issue belongs to the Section Medical Research)
Behavioral Manifestations and Neural Regulation of Movements submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open
Keywords: motor control; movement behavior; sensorimotor integration; neurophysiology; emotion and movement; cognitive-motor interaction; temperament; neurotechnology; rehabilitation; performance
(This special issue belongs to the Section Physiology and Pathology)
15th Anniversary of Life—Emerging Plant-Based Materials and Bioactive Compounds in Biomedical Applications
edited by
submission deadline 30 Apr 2026 | Viewed by 108 | Submission Open
Keywords: plant-derived materials; bioactive compounds; phytochemicals; biomedical applications; natural products; plant-based polymers; drug delivery; tissue engineering
(This special issue belongs to the Section Plant Science)
Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 101 | Submission Open
Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease
Cortical Development and Neurotransmission
edited by Christine Hohmann and Joanne Berger-Sweeney
submission deadline 30 Apr 2026 | Viewed by 91 | Submission Open
Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism
(This special issue belongs to the Section Medical Research)
Advances in Sustainable Animal Nutrition: Impacts on Physiology, Health, and Production submission deadline 30 Apr 2026 | Viewed by 88 | Submission Open
Keywords: animal nutrition; alternative feedstuffs; physiology; gut health; nutrient metabolism; immune function; animal performance; sustainable livestock production
(This special issue belongs to the Section Animal Science)
Developmental Programming in Cats and Dogs
edited by , and Sylvie Chastant
submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open
Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering
(This special issue belongs to the Section Animal Science)
Genetic Drivers in Endocrine Disorders: From Rare Variants to Aggressive Malignancies submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open
Keywords: endocrine tumors; rare variants; somatic variants; next-generation sequencing; molecular pathology; differentially expressed genes; aggressive tumor phenotype; novel genetic tests
(This special issue belongs to the Section Genetics and Genomics)
Novel Diagnostics and Therapeutics for Ophthalmic Diseases
edited by
submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open
Keywords: clinical ophthalmology; ophthalmic innovations; diagnostic technologies; therapeutic advancements; surgical techniques; disparity in global eye health; personalized medicine
(This special issue belongs to the Section Medical Research)
Research and Management of Endocrine Tumors submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open
Keywords: thyroid cancer; papillary thyroid cancer; anaplastic thyroid cancer; radioiodine; multiple kinase and angiogenetic factor inhibitors; adrenal cancer; pituitary adenomas
(This special issue belongs to the Section Medical Research)
Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome
edited by Gwo-Ping Jong
submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open
Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; coronary artery disease; endothelial dysfunction; stroke; hypertension; peripheric arterial disease; metabolic dysfunction; hyperlipidemia
(This special issue belongs to the Section Physiology and Pathology)
Advanced Research in Plant Physiology, Metabolism and Signal Transduction
edited by Xiaomin Wang
submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open
Keywords: plant development; plant– environment interaction; plant– microbe interactions; signaling transduction; stress adaptation
(This special issue belongs to the Section Plant Science)
Research and Management in Autoimmune Rheumatic Diseases submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: autoimmune rheumatic diseases; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; Sjogren's syndrome; biologic agents; JAK inhibitors
(This special issue belongs to the Section Medical Research)
Targeting DEK and TGF-β Signaling in Gynecologic Disease and Cancer: Diagnostic and Therapeutic Perspectives
edited by and Anastasia Tsigkou
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: DEK oncogene; TGF-β signaling; cervical cancer; endometriosis; uterine myomas; cancer biomarkers; epithelial– mesenchymal transition (EMT); SMAD2/3 phosphorylation; LY364947; targeted therapy
(This special issue belongs to the Section Medical Research)
Advances in Disease Mechanisms and Treatment Innovations in Rhinology and Allergy
edited by
submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open
Keywords: sinonasal disorder  ; chronic rhinosinusitis  ; rhinitis  ; empty nose syndrome  ; nasal septal deviation  ; obstructive sleep apnea  ; sinonasal tumor  ; skull base surgery  ; pediatric otorhinolaryngology
(This special issue belongs to the Section Medical Research)
Decoding Helicobacter pylori: Genetic Secrets, Flagellar Motility, and Biofilm Mechanisms
edited by Xiaolin Liu and Shuai Hu
submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open
Keywords: virulence genes; motility; flagella; biofilm; antibiotic resistance; colonization; Helicobacter pylori
(This special issue belongs to the Section Microbiology)
Advances on Tissue Engineering in Reproduction submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open
Keywords: translational regenerative medicine; bioengineered scaffolds; organoids and organ-on-a-chip; in vitro models; extracellular matrix on reproduction and regeneration
(This special issue belongs to the Section Animal Science)
Novel Biomarkers for Lymphoma Diagnosis and Prognosis: Translating Research into Practice
edited by Dominic Kaddu-Mulindwa
submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open
Keywords: lymphoma; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); molecular profiling; tumor microenvironment; epigenetic markers; predictive diagnostics
(This special issue belongs to the Section Physiology and Pathology)
Breakthroughs in Radiotherapy for Cancer submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open
Keywords: radiotherapy; radioimmunotherapy; AI-enhanced radiotherapy; bio-guided radiotherapy
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Diabetes, Microbiome, and Inflammation: Mechanisms and Therapeutic Perspectives submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open
Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis
(This special issue belongs to the Section Medical Research)
Current Challenges in Prognostic Assessment and Intervention Strategies in Acute and Critical Care
edited by
submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open
Keywords: acute and critical care; prognostic assessment; biomarkers; therapeutic strategies; sepsis; trauma; cardiac arrest; respiratory failure/ARDS; neurocritical care; implementation; patient-centered outcomes keyword
(This special issue belongs to the Section Medical Research)
Ultrasound-Guided Interventions and Advances in Musculoskeletal Disorders
edited by Chih-Ya Chang
submission deadline 5 May 2026 | Viewed by 34 | Submission Open
Keywords: ultrasound-guided interventions; regenerative medicine; platelet-rich plasma (PRP); musculoskeletal disorders; shoulder and knee osteoarthritis; peripheral nerve injuries
(This special issue belongs to the Section Medical Research)
Exploration of Gene Regulation and Therapeutic Targets in Refractory Cancers
edited by Wei-Chieh Huang
submission deadline 6 May 2026 | Viewed by 40 | Submission Open
Keywords: refractory cancers; gene regulation; targeted therapy; drug resistance
(This special issue belongs to the Section Medical Research)
Melatonin Signaling: Therapeutic Implications and Molecular Mechanisms submission deadline 15 May 2026 | Viewed by 331 | Submission Open
Keywords: melatonin; AANAT; HIOMT; MTNR1A; MTNR1B; circadian rhythms
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Crop Genetics and Breeding: 2nd Edition
edited by , , and Long Chen
submission deadline 15 May 2026 | Viewed by 46 | Submission Open
Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection
(This special issue belongs to the Section Plant Science)
Cancer Epidemiology
edited by Daniela-Cristina Stefan and Honoré K. Mitonga
submission deadline 18 May 2026 | 5 articles | Viewed by 7435 | Submission Open
Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies
(This special issue belongs to the Section Epidemiology)
Vestibular Disorders: Pathogenesis and Modern Diagnostic Approaches
edited by Kazimierz Niemczyk and Agnieszka Jasińska-Nowacka
submission deadline 18 May 2026 | Viewed by 20 | Submission Open
Keywords: vestibular disorders; Mé niè re’ s disease; vestibular migraine; vertigo; perilymph; endolymph
(This special issue belongs to the Section Medical Research)
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