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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3333 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Advancing Nanotechnology in Cancer Theranostics

edited by

Yulia Merkher

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1923 | Submission Open

Keywords: nanotechnology; cancer; nanoscale materials; nanoparticles; diagnostic accuracy; therapeutic efficacy; metastasis detection and prediction; targeted drug delivery; personalized cancer therapy

(This special issue belongs to the Section Medical Research)

Metabolic Research in Animal Nutrition

edited by

Sylwia Szymańczyk

Marek Bienko

and

Radosław P. Radzki

submission deadline 30 Jan 2026 | Viewed by 387 | Submission Open

Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics

(This special issue belongs to the Section Animal Science)

3D Imaging and Facial Reconstruction

edited by Marios Papadakis

submission deadline 30 Jan 2026 | Viewed by 373 | Submission Open

Keywords: 3D imaging; facial plastic surgery; reconstructive surgery; virtual surgical planning; custom implants; preoperative planning; intraoperative navigation

(This special issue belongs to the Section Medical Research)

Targeting Hormonal Regulation in Prostate Cancer

edited by Marília Figueira

submission deadline 30 Jan 2026 | Viewed by 279 | Submission Open

Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance

(This special issue belongs to the Section Medical Research)

Nutrition–Physiology Interactions in Aquatic Species

edited by

Dizhi Xie

Songlin Li

and

Kangle Lu

submission deadline 30 Jan 2026 | Viewed by 85 | Submission Open

Keywords: aquatic animal nutrition; fish physiology; sustainable aquaculture; alternative lipid sources; alternative protein sources; gut– microbiota interactions

(This special issue belongs to the Section Animal Science)

Physical Medicine and Rehabilitation: Trends and Applications—4th Edition

edited by

and

submission deadline 30 Jan 2026 | Viewed by 70 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

New Advances in Neuroimaging and Brain Functions: 2nd Edition

edited by

Ming-Chang Chiang

and

Chiahui Yen

submission deadline 31 Jan 2026 | 3 articles | Viewed by 13333 | Submission Open

Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Pancreatic Cancer: Long Survivals

edited by Francesco Leonardi and

Ingrid Garajova

submission deadline 31 Jan 2026 | 1 articles | Viewed by 5689 | Submission Open

Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS

(This special issue belongs to the Section Physiology and Pathology)

Pain and Therapy: Historical Perspectives and Future Directions

edited by

Francesco Scaglione

and

Arianna Pani

submission deadline 31 Jan 2026 | 6 articles | Viewed by 5017 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Medical Research)

Recent Advances in Valve Therapy: Clinical and Molecular Perspectives

edited by

Panayotis Vlachakis

, Konstantinos Toutouzas and Constantina Aggeli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 833 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease

(This special issue belongs to the Section Medical Research)

Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms

edited by

Chia-Jui Weng

submission deadline 31 Jan 2026 | Viewed by 757 | Submission Open

Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites

(This special issue belongs to the Section Medical Research)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Advances in Emergency and Critical Care Medicine

edited by

Yu-Jang Su

submission deadline 31 Jan 2026 | Viewed by 572 | Submission Open

Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly

(This special issue belongs to the Section Medical Research)

Advances in Cardiac Arrest: Prognostic Performance and Management

edited by

Kei Hayashida

submission deadline 31 Jan 2026 | 1 articles | Viewed by 563 | Submission Open

Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine

(This special issue belongs to the Section Medical Research)

Plant–Soil Interactions Under Global Change

edited by

Tao Zhang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 412 | Submission Open

Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development

(This special issue belongs to the Section Plant Science)

Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions

edited by Yung-Li Wang

submission deadline 31 Jan 2026 | Viewed by 317 | Submission Open

Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function

(This special issue belongs to the Section Physiology and Pathology)

Parasite Detection, Control Strategies and Risk Factors Related to Reproductive Health in Livestock

edited by

Ioannis Tsakmakidis

and

Ioannis Giantsis

submission deadline 31 Jan 2026 | Viewed by 314 | Submission Open

Keywords: livestock; parasite control; reproductive health; management

(This special issue belongs to the Section Animal Science)

Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development: Second Edition

edited by

Tadahiro Nagaoka

submission deadline 31 Jan 2026 | Viewed by 179 | Submission Open

Keywords: cell asymmetry; cell polarity; tissue morphogenesis; planar cell polarity (PCP) pathway; Wnt pathway; therapeutic implications

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Pig Microbiota Metabolism and Intestinal Health

edited by

Qi-Ye Wang

submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open

Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health

(This special issue belongs to the Section Animal Science)

Intracerebral Hemorrhage: Advances and Perspectives

edited by Ane Claudia Fernandes Nunes

submission deadline 31 Jan 2026 | Viewed by 82 | Submission Open

Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease

(This special issue belongs to the Section Physiology and Pathology)

Prevention, Diagnosis, and Treatment of Gestational Diseases

edited by

Andrea Suranyi

submission deadline 31 Jan 2026 | Viewed by 73 | Submission Open

Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications

(This special issue belongs to the Section Medical Research)

Liver Disease: Pathogenesis, Diagnosis, and Treatments

edited by Hsien-Hui Chung

submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open

Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies

(This special issue belongs to the Section Medical Research)

The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations

edited by

Amer Ahmed

and

Barbara Illi

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology

(This special issue belongs to the Section Physiology and Pathology)

Advances in Female Imaging: Focus on Breast and Gynecological Diagnostics

edited by Silvia Gigli, Emanuele David and Giacomo Bonito

submission deadline 31 Jan 2026 | Viewed by 62 | Submission Open

Keywords: breast cancer; breast screening; gynecological cancer; mammography; CEM; ultrasound; MRI; PET/TC; radiomics; artificial intelligence

(This special issue belongs to the Section Medical Research)

Microbiome–Gut–Brain Connections: New Windows into Health and Disease

edited by

Yating Wan

and Qi Su

submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open

Keywords: gut microbes; gut– brain axis; neuroscience

(This special issue belongs to the Section Microbiology)

Advances in the Rehabilitation of Stroke

edited by

Chia Huei Lin

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation

(This special issue belongs to the Section Medical Research)

Cancer Genetics and Genomics: From Structure to Therapy

edited by Luca Járomi and Gellért Gerencsér

submission deadline 31 Jan 2026 | Viewed by 47 | Submission Open

Keywords: epigenetics; cancer therapy; multidrug resistance (MDR); accumulation; biomarkers

(This special issue belongs to the Section Genetics and Genomics)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Microbial Biotechnology and Biomanufacturing

edited by

Sheng Tong

Dexin Wang

and

Guirong Tang

submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open

Keywords: synthetic biology tools; microbial biomanufacturing; future foods; bulk chemicals; plant natural products

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

Brain Health for All Ages: Leave No One Behind

edited by

Tissa Wijeratne

and Dilani Wijeratne

submission deadline 31 Jan 2026 | Viewed by 40 | Submission Open

Keywords: brain health; neurology; neurological syndromes

(This special issue belongs to the Section Medical Research)

Chemical Evolutionary Pathways to Origins of Life

edited by

Claudia Huber

and Christian Seitz

submission deadline 31 Jan 2026 | Viewed by 37 | Submission Open

Keywords: origin of life; metabolism-first; early Earth; iron– sulfur world; chemical evolution ; cellularization; surface catalysis; pioneer organism

(This special issue belongs to the Section Origin of Life)

New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders

edited by Mihai Lazar

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

The Biological Impacts of Fetal Alcohol Exposure

edited by Kelly J. Huffman

submission deadline 31 Jan 2026 | Viewed by 26 | Submission Open

Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure

(This special issue belongs to the Section Reproductive and Developmental Biology)

Advanced Machine Learning for Bio-Signal Processing and Health Monitoring

edited by

Amin Hekmatmanesh

submission deadline 31 Jan 2026 | Viewed by 7 | Submission Open

Keywords: brain– computer interface (BCI); electroencephalogram (EEG); machine learning; biomedical signal processing; brain computer interface; health monitoring

(This special issue belongs to the Section Medical Research)

Mechanisms and Ecology of Migration and Homing

edited by Hynek Burda

submission deadline 1 Feb 2026 | Viewed by 22 | Submission Open

Keywords: migration; homing; navigation; spatial orientation; magnetoreception; cognitive maps; seasonality; spatial memory

(This special issue belongs to the Section Diversity and Ecology)

Advances in Endoscopic, Surgical, and Interventional Radiological Management of Gastrointestinal Diseases

edited by

Beata Jabłońska

submission deadline 6 Feb 2026 | 3 articles | Viewed by 5198 | Submission Open

Keywords: gastrointestinal disease; endoscopic cystogastrostomy; endoscopic biliary prosthesis; endoscopic pancreatic prosthesis; endoscopic necrosectomy; esophagectomy; gastrectomy; bowel resection; colectomy; pancreatectomy; hepatectomy; liver transplantation; gastroenterology; surgery; interventional radiology

(This special issue belongs to the Section Medical Research)

Pain Epidemiology

edited by

Gergely Fehér

submission deadline 14 Feb 2026 | Viewed by 45 | Submission Open

Keywords: pain epidemiology; chronic pain; neuropathic pain; nociplastic pain; headache; migraine; orofacial pain; low back pain

(This special issue belongs to the Section Epidemiology)

Prebiotic Chemistry: The Molecular Origins of Life

edited by

Nigel Mason

submission deadline 15 Feb 2026 | Viewed by 35 | Submission Open

Keywords: astrobiology; astrochemistry; biochemistry; computational modelling; geochemistry; metabolic pathways; lipid formation; peptide synthesis; photochemistry; radiation chemistry; RNA world; self-assembly; systems chemistry

(This special issue belongs to the Section Origin of Life)

Microbiome Dynamics: Advancing Therapeutic Development in Health and Disease

edited by

Hoonhee Seo

, Sukyung Kim and

Md Abdur Rahim

submission deadline 16 Feb 2026 | Viewed by 53 | Submission Open

Keywords: next-generation probiotics (NGPs); microbiome-based therapeutics; metagenomics and multi-omics integration; microbial biomarkers; short-chain fatty acids (SCFAs); artificial human microbiome simulators; GMP-scale production; clinical translation

(This special issue belongs to the Section Microbiology)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 18 Feb 2026 | Viewed by 12 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Current Challenges in Human Space Flight

edited by

Larry D. Sanford

and

Richard A. Britten

submission deadline 20 Feb 2026 | 4 articles | Viewed by 11344 | Submission Open

Keywords: cognition; microgravity; sleep; stress; Martian and lunar dust; neural stem cells and progenitors

(This special issue belongs to the Section Astrobiology)

Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights

edited by

Robert Smith

Tyler Neltner

Dimitrije Cabarkapa

and Luke Chowning

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: resistance exercise; aerobic exercise; neuromuscular; kinematics; kinetics; biomechanics; electromyography; imaging techniques; muscle function; motion analysis; sport performance

(This special issue belongs to the Section Medical Research)

Mucopolysaccharidosis-Plus: From Molecular Defects to Therapeutic Strategies

edited by Zuzanna Cyske

submission deadline 20 Feb 2026 | Viewed by 15 | Submission Open

Keywords: mucopolysaccharidosis; mucopolysaccharidosis-plus syndrome; MPSPS; VPS33A; therapy; patomechanism; diagnostic; patients’ care

(This special issue belongs to the Section Medical Research)

Biomechanics of Aging

edited by

Márcio Fagundes Goethel

and

Filipa Sousa

submission deadline 26 Feb 2026 | Viewed by 73 | Submission Open

Keywords: aging; biomechanics; musculoskeletal; gait; balance; falls; exercise; assistive devices

(This special issue belongs to the Section Physiology and Pathology)

Skin Aging and Dermatosis

edited by Edwin Lephart and Zoe D. Draelos

submission deadline 26 Feb 2026 | Viewed by 63 | Submission Open

Keywords: skin aging; chronological dermal aging; photo-aging; hormone therapy; menopause; estrogen-deficient skin; dermatosis; skin conditions

(This special issue belongs to the Section Medical Research)

The Link Between Food Safety and Microbiology

edited by

Babak Pakbin

submission deadline 26 Feb 2026 | Viewed by 60 | Submission Open

Keywords: food safety; food microbiology; beneficial microbes; food preservation; food safety enhancement

(This special issue belongs to the Section Microbiology)

Oral Health: Microbial Dynamics and Antibiotic Stewardship

edited by Kristina Peroš

submission deadline 26 Feb 2026 | Viewed by 50 | Submission Open

Keywords: oral health; oral microbiota; microbial dynamics; antibiotic stewardship

(This special issue belongs to the Section Microbiology)

Conservative Management of Chronic Disease—2nd Edition

edited by

Jonathan Sinclair

submission deadline 26 Feb 2026 | Viewed by 40 | Submission Open

Keywords: chronic disease; conservative management; trial protocol; clinical research; interventions

(This special issue belongs to the Section Medical Research)

Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies

edited by Szabolcs Várbíró,

Keszthelyi Márton

, Richárd Tóth and Balázs Lintner

submission deadline 26 Feb 2026 | Viewed by 6 | Submission Open

Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’ s health innovation; quality of life; personalized therapy

(This special issue belongs to the Section Medical Research)

Displaying special issue 351-400 on page 8 of 10.

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