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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity

edited by Elisa Na

submission deadline 31 Dec 2025 | 1 articles | Viewed by 710 | Submission Open

Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics

(This special issue belongs to the Section Physiology and Pathology)

Diagnosis and Treatment of Erectile Dysfunction

edited by

Geng-Long Hsu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 531 | Submission Open

Keywords: erectile dysfunction; non-invasive methods; surgical strategies

(This special issue belongs to the Section Physiology and Pathology)

Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management

edited by

Yiwen Lin

and I-Han Hsiao

submission deadline 31 Dec 2025 | Viewed by 525 | Submission Open

Keywords: pain; mechanisms; signaling pathways; diagnosis

(This special issue belongs to the Section Physiology and Pathology)

Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment

edited by

Mengliang Zhang

and Hans Hultborn

submission deadline 31 Dec 2025 | Viewed by 507 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements

(This special issue belongs to the Section Medical Research)

Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges

edited by Pei-Ju Chao,

Tsair-Fwu Lee

Peter Elkin

and

Roberto Iezzi

submission deadline 31 Dec 2025 | Viewed by 333 | Submission Open

Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration

(This special issue belongs to the Section Medical Research)

The Interactions Between Cells and Their Microenvironment

edited by

Ping Yang

and

Haitao Nie

submission deadline 31 Dec 2025 | Viewed by 330 | Submission Open

Keywords: cell microenvironment; extracellular matrix; interstitial cells

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Dec 2025 | Viewed by 319 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions

(This special issue belongs to the Section Animal Science)

Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides

edited by

Yanchun Deng

and

Xiushi Yang

submission deadline 31 Dec 2025 | Viewed by 280 | Submission Open

Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging

(This special issue belongs to the Section Pharmaceutical Science)

Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease

edited by Anusha Vaddi

submission deadline 31 Dec 2025 | Viewed by 278 | Submission Open

Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology

(This special issue belongs to the Section Medical Research)

The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache

edited by

Masahito Katsuki

Tomokazu Shimazu

, Muneto Tatsumoto and Shingo Shimoda

submission deadline 31 Dec 2025 | Viewed by 268 | Submission Open

Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences

(This special issue belongs to the Section Medical Research)

Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations

edited by Manuel Gil Lozano and Marina Romaní-Pérez

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin

(This special issue belongs to the Section Physiology and Pathology)

Plant Adaptation Mechanisms to Abiotic Stresses

edited by Sunchung Park and Ezekiel Ahn

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors

(This special issue belongs to the Section Plant Science)

Animal Reproduction and Health

edited by

Rachel Moxon

and

Ana Faustino

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development

(This special issue belongs to the Section Animal Science)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 31 Dec 2025 | Viewed by 116 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine

edited by

Ana Catarina Duarte

submission deadline 31 Dec 2025 | Viewed by 104 | Submission Open

Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice

edited by

Dimitris Tousoulis

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy

(This special issue belongs to the Section Medical Research)

Airway Management in Emergency and Intensive Care Medicine

edited by Prashant Nasa and Tonny V. Veenith

submission deadline 31 Dec 2025 | Viewed by 99 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Bioactive Compounds for Medicine and Health

edited by

Christiana Charalambous

and

Alexandru Vasincu

submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open

Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition

edited by

and

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality

(This special issue belongs to the Section Plant Science)

The Biology and Functions of Platelets: Emerging Challenges

edited by

Robert Maitta

and Miriam Andrea Duque

submission deadline 31 Dec 2025 | Viewed by 71 | Submission Open

Keywords: platelet; hemostasis; toll-like receptor; immunity; phagocytosis; transfusions; von Willebrand factor; thrombocyte

(This special issue belongs to the Section Physiology and Pathology)

Origin of Life in Chemically Complex Messy Environments: 3rd Edition

edited by

Ranajay Saha

and

Alberto Vázquez-Salazar

submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open

Keywords: origin of life; complex chemical systems ; prebiotic chemistry ; prebiotic metabolisms ; chemical evolution ; prebiotic catalysts

(This special issue belongs to the Section Origin of Life)

Advancements in Heart Failure Research: 2nd Edition

edited by Tzu-Hurng Cheng,

Ju-Chi Liu

and

Po-Yuan Chen

submission deadline 31 Dec 2025 | Viewed by 62 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; patient-centered care; therapeutic innovations

(This special issue belongs to the Section Physiology and Pathology)

Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management

edited by

Anna Lisa Montemari

submission deadline 31 Dec 2025 | Viewed by 43 | Submission Open

Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Dec 2025 | Viewed by 39 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Effects of Exercise and Functional Interventions on Musculoskeletal Health

edited by

Seong-Gil Kim

submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open

Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science

Understanding Brain Disorders Through EEG and AI

edited by Debashis Das Chakladar and

Giuseppe Augusto Chiarenza

submission deadline 31 Dec 2025 | Viewed by 32 | Submission Open

Keywords: EEG; ADHD; Alzheimer’ s; Parkinson’ s; neurological disorders; machine learning; deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Traumatic Brain Injury: Epidemiology, Diagnosis, Treatment and Biomarkers

edited by

Jeff Victoroff

and

Alfredo Conti

submission deadline 31 Dec 2025 | Viewed by 31 | Submission Open

Keywords: traumatic brain injury; neurotrauma; epidemiology; rehabilitation; neurological disorders; biomarkers

(This special issue belongs to the Section Physiology and Pathology)

Leveraging the Power of Enzymes in Biotechnological Applications

edited by

Shengwei Sun

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application

Research on Female Reproductive Health and Metabolism

edited by

Alice Bongrani

submission deadline 31 Dec 2025 | Viewed by 27 | Submission Open

Keywords: female reproduction; metabolism; nutrition; adipose tissue; hypothalamus– pituitary– gonadal axis; insulin resistance; adipocytokines; reproductive disorders; PCOS

(This special issue belongs to the Section Physiology and Pathology)

Advances in Artificial Intelligence for Medical Image Analysis: 2nd Edition

edited by

Xin Jin

submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open

Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition

edited by

Emma Borrelli

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species

(This special issue belongs to the Section Pharmaceutical Science)

Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities

edited by

Jun Noda

and

Daisuke Tanaka

submission deadline 31 Dec 2025 | Viewed by 14 | Submission Open

Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics

(This special issue belongs to the Section Microbiology)

Recent Advances in Left Ventricular Unloading Therapy

edited by Mehmet Oezkur

submission deadline 31 Dec 2025 | Viewed by 13 | Submission Open

Keywords: left ventricular unloading therapy; cardiovascular medicine; heart failure; acute myocardial infarction

(This special issue belongs to the Section Medical Research)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

Research Progress in Kidney Diseases

edited by Ane Claudia Fernandes Nunes

submission deadline 15 Jan 2026 | Viewed by 60 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics

Biological Identity and Relationships Along the Nile

edited by

Kanya Godde

submission deadline 15 Jan 2026 | Viewed by 25 | Submission Open

Keywords: Nubia; Egypt; population genetics; Nile; biological affinity

Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine

edited by

Adrian Neagu

submission deadline 18 Jan 2026 | 2 articles | Viewed by 2606 | Submission Open

Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Physical Medicine and Rehabilitation: Trends and Applications—4th Edition

edited by

and

submission deadline 30 Jan 2026 | Viewed by 25 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms

edited by

Chia-Jui Weng

submission deadline 31 Jan 2026 | Viewed by 360 | Submission Open

Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites

(This special issue belongs to the Section Medical Research)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 31 Jan 2026 | 1 articles | Viewed by 317 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Pig Microbiota Metabolism and Intestinal Health

edited by

Qi-Ye Wang

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health

(This special issue belongs to the Section Animal Science)

Prevention, Diagnosis, and Treatment of Gestational Diseases

edited by

Andrea Suranyi

submission deadline 31 Jan 2026 | Viewed by 39 | Submission Open

Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications

(This special issue belongs to the Section Medical Research)

Plant–Soil Interactions Under Global Change

edited by

Tao Zhang

submission deadline 31 Jan 2026 | Viewed by 37 | Submission Open

Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development

(This special issue belongs to the Section Plant Science)

Intracerebral Hemorrhage: Advances and Perspectives

edited by Ane Claudia Fernandes Nunes

submission deadline 31 Jan 2026 | Viewed by 35 | Submission Open

Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease

(This special issue belongs to the Section Physiology and Pathology)

Cancer Genetics and Genomics: From Structure to Therapy

edited by Luca Járomi and Gellért Gerencsér

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: epigenetics; cancer therapy; multidrug resistance (MDR); accumulation; biomarkers

(This special issue belongs to the Section Genetics and Genomics)

The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations

edited by

Amer Ahmed

and

Barbara Illi

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology

(This special issue belongs to the Section Physiology and Pathology)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 31 Jan 2026 | Viewed by 23 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Liver Disease: Pathogenesis, Diagnosis, and Treatments

edited by Hsien-Hui Chung

submission deadline 31 Jan 2026 | Viewed by 21 | Submission Open

Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies

(This special issue belongs to the Section Medical Research)

Displaying special issue 351-400 on page 8 of 9.

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