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Life, Volume 16, Issue 1

2026 January - 184 articles

Cover Story: Women show a higher prevalence of mood- and stress-related disorders, yet the biological mechanisms underlying this vulnerability remain poorly understood. This review examines neuroinflammation as a sex-specific process shaping emotional regulation across the female lifespan. Integrating evidence from human and animal studies, it highlights how hormonal fluctuations interact with immune signaling, microglial activity, stress systems, and neurotransmission, creating periods of increased vulnerability during puberty, the menstrual cycle, pregnancy, the postpartum period, and perimenopause. By linking endocrine transitions to neuroimmune mechanisms, this review provides an integrated framework for female susceptibility to depression and anxiety and supports the development of sex-informed preventive and therapeutic strategies. View this paper
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Articles (184)

  • Article
  • Open Access
118 Views
10 Pages

22 January 2026

Studying the origin of life requires identifying chemical and physical processes that could have supported early self-replicating and evolving molecular systems. Besides the requirement of information storage and transfer, an essential aspect is an e...

  • Review
  • Open Access
157 Views
25 Pages

Seric Molecular Markers Correlated with Stroke Rehabilitation Outcomes: A Narrative Review

  • Bianca-Gabriela Ene,
  • Brindusa Ilinca Mitoiu,
  • Mariana Catalina Ciornei,
  • Madalina Coman-Stanemir,
  • Angelo Voicu,
  • Floris Petru Iliuta and
  • Ioana Raluca Papacocea

22 January 2026

An increasing number of stroke survivors are burdened by persistent disabilities, requiring long-term rehabilitation. However, the extent of functional gain is highly variable, severely impairing patients’ quality of life. This variability high...

  • Review
  • Open Access
212 Views
23 Pages

Perianal Crohn’s Disease in Inflammatory Bowel Disease: Diagnosis, Assessment and Treatment

  • Ilaria Faggiani,
  • Isabel Lagos Villaseca,
  • Ferdinando D’Amico,
  • Federica Furfaro,
  • Alessandra Zilli,
  • Sara Massironi,
  • Tommaso Lorenzo Parigi,
  • Virginia Solitano,
  • Clelia Cicerone and
  • Mariangela Allocca
  • + 2 authors

22 January 2026

Perianal fistulizing Crohn’s disease (pfCD) represents one of the most challenging manifestations of CD, often associated with severe phenotypes, refractory luminal inflammation, and a substantial reduction in quality of life. Its pathogenesis...

  • Case Report
  • Open Access
151 Views
13 Pages

Herb-Induced Liver Injury by Laurus nobilis: A Case Assessed for Causality Using the Updated RUCAM

  • Mihnea Soare,
  • Sabina-Florina Călugăr-Șolea,
  • Ciprian Brisc,
  • Marius Rus,
  • Teodora-Maria Bodog,
  • Gabriel Becheanu,
  • Ciprian Mihai Brisc and
  • Mihaela-Cristina Brisc

22 January 2026

Hepatocellular injury syndrome represents a pathological process with a broad etiological spectrum, including viral infections, autoimmune diseases, or intoxications. Clinicians must identify the potential cause using both anamnestic data and availab...

  • Review
  • Open Access
152 Views
18 Pages

Impact of Cadmium Toxicity on Testicular Function: Risk of Male Infertility

  • Iva Arato,
  • Elena Eugeni,
  • Giuseppe Basta,
  • Tiziano Baroni,
  • Riccardo Calafiore,
  • Francesca Mancuso and
  • Giovanni Luca

22 January 2026

The World Health Organization estimates that about 15% of couples in their adult years in industrialized countries experience infertility, which is described as the inability of a sexually active and non-contraceptive couple to achieve spontaneous pr...

  • Systematic Review
  • Open Access
194 Views
20 Pages

22 January 2026

Cervical spinal cord injury causes severe functional impairment with limited spontaneous recovery, and while spinal cord stimulation has emerged as a promising neuromodulatory strategy, evidence for cervical applications remains fragmented. To addres...

  • Article
  • Open Access
122 Views
12 Pages

Monocyte Distribution Width as a Biomarker for Predicting Bacteremia: A Retrospective Study in the Emergency Department

  • Tse-Hao Chen,
  • Yu-Jang Su,
  • Wei-Hsiang Liao,
  • Weide Tsai,
  • Ding-Kuo Chien,
  • Wen-Han Chang and
  • Chyi-Huey Bai

22 January 2026

Blood culture is the diagnostic gold standard for bacteremia in the emergency department (ED), but its turnaround time can delay appropriate antimicrobial therapy, highlighting the need for rapid, accessible biomarkers. We retrospectively analyzed ad...

  • Article
  • Open Access
128 Views
12 Pages

Erythema Protection Efficacy of Plant-Derivative Compounds in Mice Based on Narrow-Band Reflectance Spectroscopy Data

  • Diego Armando Villamizar Mantilla,
  • Luis Alberto Nuñez,
  • Elena E. Stashenko,
  • María Pilar Vinardell and
  • Jorge Luis Fuentes

21 January 2026

Background: Plants represent an important source of photoprotective compounds that are capable of protecting human skin from solar-induced damage. In this study we investigated the suitability of a murine model for estimating the Erythema Protection...

  • Article
  • Open Access
124 Views
21 Pages

21 January 2026

Air pollution has been one of the major threats to public health. The study aimed to determine latent patterns of geographical distribution of health-related air pollutants across the USA and to evaluate real-world cumulative effects of these pattern...

  • Review
  • Open Access
227 Views
58 Pages

Medicinal Plants and Phytochemicals in Cardioprotection—Mechanistic Pathways and Translational Roadmap

  • Diana Maria Morariu-Briciu,
  • Alex-Robert Jîjie,
  • Sorin Lucian Bolintineanu,
  • Ana-Maria Pah,
  • Sorin Dan Chiriac,
  • Adelina Chevereșan,
  • Victor Dumitrașcu,
  • Cătălin Prodan Bărbulescu and
  • Radu Jipa

21 January 2026

Despite major advances in guideline-directed cardiovascular therapy, residual cardiovascular risk persists, partly driven by oxidative stress, chronic inflammation, endothelial dysfunction, and mitochondrial injury not fully addressed by current drug...

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Life - ISSN 2075-1729