The Roles and Regulation of RECK in Cell Behavior, Animal Development, and Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 31 October 2026
Special Issue Editors
Interests: cancer; angiogenesis; neural development
Interests: cancer; inflammatory; carcinogens; inflammatory bowel diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
RECK was first discovered as a transformation suppressor gene by cDNA expression screening. Subsequent studies indicate that RECK downregulation is widely found in human cancer and is causally involved in carcinogenesis. RECK was also found to be involved in multiple events during mammalian embryogenesis. Moreover, recent studies indicate the involvement of RECK in several diseases other than cancer. RECK encodes a relatively large (~125 kDa), extracellular, membrane-anchored glycoprotein with two distinct molecular functions: (1) matrix metalloproteases regulator and (2) a ligand-binding component of the WNT7 receptor. We still do not know, however, whether all the RECK biological activities discovered so far are attributable to these two molecular functions. We believe it is important to continue to collect more information on the molecular properties of the RECK protein, the mechanisms regulating its expression and activities, the mechanisms by which RECK regulates gene expression and cellular behavior, the mechanisms by which RECK affects animal development, and the mechanisms by which RECK affects various diseases. We expect that such studies focusing on this unique, interesting, and still mysterious macromolecule will bring us fresh insights and breakthroughs in biology and medicine.
Prof. Dr. Makoto Noda
Prof. Dr. David B. Alexander
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- metastasis
- cell migration
- angiogenesis
- neurogenesis
- extracellular matrix
- disease models
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
