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Life, Volume 15, Issue 12

December 2025 - 158 articles

Cover Story: Extreme environments harbour an unexplored treasure trove of extremophile microorganisms, adapted to harsh conditions. Extremophiles produce unique compounds which exhibit antioxidant, anti-inflammatory, photoprotective, and regenerative properties. The integration of extremophile-derived bioactives into cosmeceuticals and nutricosmetics provides a new means of improving skin health through both topical and systemic approaches. Extremophile-derived ingredients combine biological efficacy with environmental sustainability, positioning them as key assets for next-generation skincare. Future directions include clinical validation, regulatory harmonization, and the development of personalized, microbiome-friendly formulations. View this paper
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Articles (158)

  • Article
  • Open Access
357 Views
24 Pages

Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study

  • Evgenii Kukaev,
  • Olga Krogh-Jensen,
  • Natalia Starodubtseva,
  • Alisa Tokareva,
  • Irina Nikitina,
  • Anna Lenyushkina,
  • Vladimir Frankevich and
  • Gennady Sukhikh

18 December 2025

Background: Early-onset neonatal sepsis (EONS), defined as systemic infection occurring within the first 72 hours of life, remains a major cause of morbidity and mortality in preterm infants. Increasing evidence indicates that the gut may play an act...

  • Article
  • Open Access
335 Views
13 Pages

Long-Term Effects of Elexacaftor/Tezacaftor/Ivacaftor on Nocturnal Cardiorespiratory Polygraphy Parameters in Patients with Cystic Fibrosis: A Prospective Study

  • Monica Tosto,
  • Giuseppe Fabio Parisi,
  • Santiago Presti,
  • Maria Papale,
  • Giulia Pecora,
  • Enza Mulè,
  • Vittorio Ornato,
  • Donatella Aloisio,
  • Sara Manti and
  • Salvatore Leonardi

18 December 2025

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to multi-system impairment. Sleep respiratory disorders (SRDs) are frequent in individuals with CF—even in those with normal or mildly impaired lung functi...

  • Article
  • Open Access
318 Views
11 Pages

The Influence of Demographic Characteristics, Pre-Existing Conditions and Laboratory Parameters on Postoperative Hemorrhage After Brain Tumor Surgery

  • Anatoli Pinchuk,
  • Nikolay Tonchev,
  • Anna Schaufler,
  • Claudia A. Dumitru,
  • Klaus-Peter Stein,
  • Belal Neyazi,
  • I. Erol Sandalcioglu and
  • Ali Rashidi

18 December 2025

Background: Postoperative hemorrhage (POH) is a rare yet serious complication of cranial surgery, potentially resulting in extended hospitalization, neurological impairment, or death. Existing predictive models often encompass diverse cranial patholo...

  • Article
  • Open Access
708 Views
20 Pages

Bat Cave Vulnerability to Anthropogenic Factors: Status and Priorities for Conservation Within the Mount Elgon Region, Uganda

  • Aggrey Siya,
  • Benard Matovu,
  • Lillian Nalukenge,
  • Micheal Mutebi,
  • Betty Nalikka,
  • Kevin Castle,
  • Tanya Dewey,
  • Kalani M. Williams,
  • Natalie R. Wickenkamp and
  • Emma K. Harris
  • + 5 authors

18 December 2025

Uganda is home to a rich diversity of bats, which carry high ecological and socioeconomic value through the ecosystem services that they provide. However, critical bat habitats, including caves, are facing increasing anthropogenic pressures, and the...

  • Article
  • Open Access
312 Views
16 Pages

In Vivo Assessment of Anti-Inflammatory Effects of Aqueous Extracts of Nepeta nuda ssp. nuda L. in Experimental Model of Peripheral Inflammation in Male Long Evans Rats

  • Milena Keremidarska-Markova,
  • Veneta Evtimova-Koeva,
  • Tsvetozar Penchev,
  • Dilyana Doncheva-Stoimenova,
  • Miroslava Zhiponova,
  • Mariela Chichova and
  • Bilyana Ilieva

18 December 2025

Background: Recently various plants have attracted considerable scientific interest as potential therapeutic alternatives to known drugs used in anti-inflammatory therapy. Therefore, we have investigated the possible anti-inflammatory and analgesic e...

  • Article
  • Open Access
573 Views
21 Pages

Pharyngeal Airway Changes After Functional Orthodontic Treatment in Growing Class II Patients: A Retrospective Cephalometric Comparison of Twin Block, RPE and AMCOP®

  • Alessio Danilo Inchingolo,
  • Angelo Michele Inchingolo,
  • Irene Palumbo,
  • Daniela Di Venere,
  • Cinzia Maspero,
  • Francesco Inchingolo,
  • Filippo Cardarelli,
  • Grazia Marinelli and
  • Gianna Dipalma

18 December 2025

Pharyngeal airway morphology is closely linked to craniofacial development, and children with Class II malocclusion—often characterized by mandibular retrusion—may present reduced airway dimensions and a higher risk of obstructive sleep a...

  • Article
  • Open Access
262 Views
15 Pages

Assessment of Genotoxicity and Cytotoxicity of Tepary Bean (Phaseolus acutifolius) Seed Protein Extract

  • Carmen Valadez-Vega,
  • Lizbeth Ortigoza-Fonseca,
  • Gabriel Betanzos-Cabrera,
  • Raúl Velasco-Azorsa,
  • Víctor Manuel Muñoz-Pérez,
  • José A. Morales-González,
  • Belinda Patricia Velázquez-Morales,
  • Aurea Bernardino-Nicanor,
  • Leopoldo González-Cruz and
  • Diego Estrada-Luna
  • + 1 author

18 December 2025

Beans are widely consumed worldwide and are a good source of amino acids and micronutrients; however, they contain anti-nutrients, such as lectins, tannins, protein inhibitors, saponins, and phytic acid, among others, which can reduce the food’...

  • Article
  • Open Access
357 Views
12 Pages

The Umbilical Cord Clamp Method—Procedural Description and Safety Assessment of a Novel Method of Umbilical Catheter Fixation After Side Entry Insertion

  • Anna Tomaszkiewicz,
  • Piotr Kruczek,
  • Piotr Szymański,
  • Piotr Teplicki,
  • Rita Abu Faraj-Batko,
  • Alina Sobczak,
  • Sonia Kahtan,
  • Boris W. Kramer and
  • Jan Mazela

18 December 2025

Background: Umbilical venous catheter (UVC) placement is common in neonates but carries risks of migration and infection. This study evaluates safety of a novel fixation technique using the umbilical cord clamp after a side-entry insertion. Methods:...

  • Article
  • Open Access
343 Views
7 Pages

Outpatient Management of Aural Fullness: A Retrospective Case Series of 100 Patients with Cerumen Impaction, Keratosis Obturans, and External Auditory Canal Cholesteatoma

  • Giovanni Motta,
  • Domenico Testa,
  • Giuseppe Barba,
  • Rosa Grassia,
  • Francesco Chiari,
  • Arianna Di Stadio and
  • Giuseppe Tortoriello

18 December 2025

Background: Aural fullness is a common symptom in routine otolaryngological practice. Although it is most commonly attributed to cerumen impaction, other, less frequent conditions may present similar symptoms and are often initially misdiagnosed as c...

  • Article
  • Open Access
273 Views
14 Pages

18 December 2025

Intrinsic aging and external stimuli such as UV exposure contribute to heightened MMP-1 expression, leading to collagen deterioration and weakening of the skin’s structural framework, hallmarks of aging tissue. Peucedanum japonicum, a plant con...

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Life - ISSN 2075-1729