2025 December - 158 articles
Background: Early-onset neonatal sepsis (EONS), defined as systemic infection occurring within the first 72 hours of life, remains a major cause of morbidity and mortality in preterm infants. Increasing evidence indicates that the gut may play an act...
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene, leading to multi-system impairment. Sleep respiratory disorders (SRDs) are frequent in individuals with CF—even in those with normal or mildly impaired lung functi...
Background: Postoperative hemorrhage (POH) is a rare yet serious complication of cranial surgery, potentially resulting in extended hospitalization, neurological impairment, or death. Existing predictive models often encompass diverse cranial patholo...
Uganda is home to a rich diversity of bats, which carry high ecological and socioeconomic value through the ecosystem services that they provide. However, critical bat habitats, including caves, are facing increasing anthropogenic pressures, and the...
Background: Recently various plants have attracted considerable scientific interest as potential therapeutic alternatives to known drugs used in anti-inflammatory therapy. Therefore, we have investigated the possible anti-inflammatory and analgesic e...
Pharyngeal airway morphology is closely linked to craniofacial development, and children with Class II malocclusion—often characterized by mandibular retrusion—may present reduced airway dimensions and a higher risk of obstructive sleep a...
Beans are widely consumed worldwide and are a good source of amino acids and micronutrients; however, they contain anti-nutrients, such as lectins, tannins, protein inhibitors, saponins, and phytic acid, among others, which can reduce the food’...
Background: Umbilical venous catheter (UVC) placement is common in neonates but carries risks of migration and infection. This study evaluates safety of a novel fixation technique using the umbilical cord clamp after a side-entry insertion. Methods:...
Background: Aural fullness is a common symptom in routine otolaryngological practice. Although it is most commonly attributed to cerumen impaction, other, less frequent conditions may present similar symptoms and are often initially misdiagnosed as c...
Intrinsic aging and external stimuli such as UV exposure contribute to heightened MMP-1 expression, leading to collagen deterioration and weakening of the skin’s structural framework, hallmarks of aging tissue. Peucedanum japonicum, a plant con...
Cyanobacterial blooms pose significant threats to aquatic ecosystems and drinking water safety, primarily through the release of diverse secondary metabolites. This study systematically explored the dynamics of secondary metabolites in Microcystis ae...
Personalized exercise prescriptions require identifying inter-individual differences in exercise intervention effects. This review examined whether true inter-individual differences exist after accounting for measurement error. PubMed, Web of Science...
Objective: Identifying biomarkers that predict metastatic potential or guide treatment selection is critical for improving breast cancer (BC) management. Previously, we established the Mitotic Network Activity Index (MNAI) as a prognostic marker in B...
Background: The benefit of adjuvant chemotherapy for low-risk, mismatch repair proficient (pMMR) stage IIA colon cancer is uncertain. Surveillance is standard, but some patients relapse. Tegafur-uracil (UFT) is a low-toxicity oral option that may off...
Purpose: This study investigated the effects of dietary bamboo leaf extract (BLE) on milk parameters and intestinal microbiota in lactating Yili mares. Methods: Twenty-four Yili mares of similar age (10 ± 2 years), weight (360.62 ± 15.2...
Background and Objectives: Trauma remains a leading global cause of preventable mortality, and outcome prediction tools are essential for both triage and resource allocation. Timely and effective medical response to trauma patients is of the essence....
Cadmium (Cd) contamination in agricultural soils threatens food security and exacerbates climate change through its impact on greenhouse gas (GHG) (CO2, N2O and CH4) emissions, in which N2O and CO2 are the dominant fluxes of the terrestrial carbon-ni...
Memory constitutes a fundamental cognitive domain, and converging evidence suggests that its dysfunction represents a prominent, though not exclusive, transdiagnostic dimension across major psychiatric disorders. This review aimed to integrate neurob...
The genetic diversity and population structure of Tunisian Arabian horses were assessed using highly polymorphic microsatellite markers, which are critical for conservation and breeding programs. Despite the cultural and economic importance of Arabia...
Fascia research suffers from definitional fragmentation, with no universal agreement about what fascia actually is, why it matters, or how to define it. Researchers often pursue lines of inquiry based on their existing expertise, yet traditional and...
Purpose: This study aimed to investigate the associations between serum per- and polyfluoroalkyl substances (PFAS) and reproductive hormones, including follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), estradiol, and progesterone...
Leukodystrophies (LDs) constitute a heterogeneous group of genetic diseases in which mutations in glial cell genes lead to alterations in myelin formation and/or maintenance, ultimately causing white matter dysfunction. Increasing evidence on the gen...
High-mountain lakes are biodiversity hotspots sensitive to increasing regional and global climate warming. However, their microbial communities remain insufficiently characterized due to their remoteness and limited accessibility. This study aimed to...
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance, particularly to β-lactam antibiotics. This study comprehensively evaluated the natural compound emodin for its anti-MRSA a...
Background: Aging is associated with progressive structural and functional changes in dentin, reducing its mechanical integrity and increasing vulnerability to damage. Among the most important regulators of dentin physiology are extracellular matrix...
Bupropion overdose can result in severe neurological and cardiovascular toxicity. We describe a 16-year-old girl who ingested 4.2 g of extended-release bupropion (90.3 mg/kg), presenting with seizures and out-of-hospital cardiac arrest. After 21 min...
Breast cancer is the most frequent and lethal type of cancer that affects women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer, having high rate of recurrence, metastasis, and mortality, with very limited...
Background: Animal studies remain fundamental to cardiovascular drug and device development, yet their ability to predict human responses is increasingly being questioned. The US Food and Drug Administration (FDA)’s April 2025 roadmap supports...
Purpose: Fetal bovine serum (FBS) is widely used in cell culture due to its rich nutrient and growth factor content, but it poses ethical concerns, biosafety risks, and cost limitations. This study investigates plasma-depleted lyophilized (freeze-dri...
Life is defined by self-governing networks of molecules that change conformation cyclically, converting thermodynamic motion into directional work and structure. A spectrum of scale, from nanoscopic to macroscopic, involves a shift from intracellular...
Objective: This study aimed to identify predictive factors for adherent perinephric fat (APF), or sticky fat, in patients undergoing laparoscopic partial nephrectomy (LPN), with particular emphasis on evaluating male gender as an independent risk fac...
Extracorporeal shockwave therapy (ESWT) represents a form of “mechanotherapy” that operates by delivering acoustic waves to biological tissues [...]
Sarcopenic obesity, the coexistence of excess adiposity with loss of muscle mass and function, is becoming increasingly prevalent. The condition is linked to higher morbidity and mortality but its diagnosis remains limited by reliance on body composi...
Classical branching-process theory, developed by Galton and Watson in the nineteenth century and later refined by Fisher and Haldane, provides the formal framework for quantifying the fate of new mutants, new viral and bacterial pathogens, new coloni...
Chromophobe renal cell carcinoma (chRCC) is a distinct subtype of non–clear cell renal cell carcinoma (ncRCC), arising from intercalated cells of the distal nephron collecting ducts. No standard treatments are specifically approved for chRCC, w...
Background: Acute pancreatitis is a significant global disease. This study investigated the phytochemical composition and potential protective effects of Equisetum arvense L. (horsetail) ethanol extract and Olea europaea L. (olive leaves) aqueous ext...
Agricultural and agro-industrial residues are increasingly recognized as sustainable, low-cost feedstocks for high-performance biomedical materials. This review critically examines the translational potential of polysaccharides, proteins, inorganic c...
Apis cerana is an important native honey bee species in China, and its body size is closely related to its production performance and environmental adaptability. Prpk (TP53-regulating kinase) has been confirmed to regulate cell growth and proliferati...
Background: Stroke is the leading cause of physical disability in adults in Catalonia. Despite this, there is a lack of evidence of physiotherapy interventions on functional capacity during the chronic phase of the pathology. This multicenter clinica...
Background: Airway management forms the most important component of pre-hospital trauma patients’ care. In such a setting, the definitive airways may be difficult to establish. This study aimed to evaluate four newer supraglottic airway devices...
The aim of this study was to investigate the molecular interactions of heparin, diclofenac, and their supramolecular complexes with cyclooxygenase enzymes (COX-1 and COX-2) using computational docking techniques. Diclofenac is a widely used nonsteroi...
Two old cases of adrenocortical tumors with contradictory diagnostic findings and opposite conclusions are revisited in light of the recent WHO guidelines, as follows: a 34-year-old woman and a 15-month-old girl, both with severe virilization and adr...
Background: Although smartphone usage is inevitable and convenient in recent days, numerous potential problems due to excessive smartphone use (ESU) have been highlighted. With the rising concern about ESU, the focus on exploring the relationship bet...
Background: The periodontal pathogen Tannerella forsythia is auxotrophic for muramic acid (MurNAc), a key component of bacterial peptidoglycan, and dependent on an external supply of MurNAc to maintain pure laboratory cultures. The focus of this stud...
Background: Fluid overload (FO) is a frequent ICU complication and an important predictor of adverse outcomes. While classically attributed to resuscitative fluids, recent data emphasize the contribution of non-therapeutic “fluid creep” f...
In the published publication [...]
Climate change significantly impacts natural environments, economies, and human health, with rising global temperatures causing increasingly frequent extreme weather events. Studies have shown that heat exposure accelerates kidney function decline an...
(1) Background: ‘Chaling’ common wild rice (CLWR), one of the two wild rice populations with the northernmost natural distribution worldwide, exhibits excellent cold tolerance. The role of microRNA (miRNA) in regulating cold tolerance in...
Nymphaea ‘Blue Bird’, a tropical water lily prized for its ornamental appeal, has been less explored as a source of bioactive flavonoids. This study developed an efficient extraction and purification protocol for flavonoids from this plan...
Background: Small bowel tumors are rare and biologically diverse, and prognostic assessment remains difficult, particularly regarding proliferative markers such as Ki-67 and tumor size. Objective: To evaluate the clinicopathological and immunohistoch...
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