Biomarkers in Ischemic Stroke: From Discovery to Clinical Applications
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 36
Special Issue Editor
Special Issue Information
Dear Colleagues,
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide; it is caused by complex interactions among vascular occlusion, metabolic stress, and neuroinflammatory cascades. Recent progress in biomarker research has deepened our understanding of the molecular and cellular events underlying ischemic brain injury and recovery, providing critical tools for early diagnosis, prognostic assessment, and therapeutic monitoring.
Emerging circulating biomarkers—such as neurofilament light chain (NfL), matrix metalloproteinases (MMPs), and inflammatory mediators—reflect neuronal injury, oxidative stress, and blood–brain barrier disruption. In parallel, imaging-based and genomic biomarkers have advanced precision in patient stratification, enabling individualized therapeutic approaches. The integration of multi-omics profiling, neuroimaging signatures, and clinical indicators represents a major step toward personalized medicine in stroke care.
This Special Issue aims to highlight cutting-edge research spanning biomarker discovery, validation, and clinical translation in ischemic stroke. We welcome studies that bridge basic mechanisms and clinical implementation, including novel diagnostic, prognostic, and therapeutic biomarkers, that may enhance treatment efficacy and improve long-term neurological outcomes.
Dr. Hock-Kean Liew
Guest Editor
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Keywords
- ischemic stroke
- biomarkers
- neuroinflammation
- oxidative stress
- excitotoxicity
- thrombolysis
- mechanical thrombectomy
- blood–brain barrier
- neuroprotection
- precision medicine
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