Ocular Diseases: Mechanisms, Diagnostics, and Emerging Therapeutic Strategies

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 891

Special Issue Editor


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Guest Editor
Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-093 Lublin, Poland
Interests: retinal diseases; macular diseases; age-related macular degeneration (AMD); intravitreal injections; retinal surgery

Special Issue Information

Dear Colleagues,

Vision is one of our most vital senses, yet ocular diseases continue to threaten sight and quality of life for millions of people worldwide. The growing prevalence of retinal degenerations, diabetic retinopathy, glaucoma, and corneal disorders highlights the urgent need for innovative strategies to improve early diagnosis, prevention, and treatment. While remarkable progress has been made in surgical techniques, imaging, and pharmacotherapy, many unanswered questions remain, and new approaches are needed to address unmet clinical challenges.

This Special Issue of Life, entitled “Ocular Diseases: Mechanisms, Diagnostics, and Emerging Therapeutic Strategies”, invites researchers, clinicians, and innovators to contribute their latest work to advance our understanding of eye disease and push the boundaries of current practice. We welcome submissions across a wide range of topics, including the following:

  • Cellular and molecular mechanisms driving ocular pathology;
  • Novel diagnostic biomarkers and next-generation imaging technologies;
  • Gene- and cell-based therapies, pharmacological interventions, and drug delivery innovations;
  • Advances in surgical procedures, regenerative medicine, and tissue engineering;
  • Personalized and precision approaches to patient care in ophthalmology.

Our goal is to create a vibrant forum where cutting-edge discoveries and translational insights converge, offering fresh perspectives that will shape the future of ocular health. By sharing your work in this Special Issue, you will join a community dedicated to advancing vision science and improving outcomes for patients worldwide.

We warmly encourage you to submit your latest findings and be part of this important endeavor.

Dr. Joanna Dolar-Szczasny
Guest Editor

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Keywords

  • molecular mechanisms of eye disease
  • oxidative stress and inflammation
  • neurodegeneration in vision
  • ocular biomarkers
  • pharmacological therapies
  • gene therapy
  • stem cell and regenerative approaches
  • precision/personalized ophthalmology

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Published Papers (1 paper)

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Research

16 pages, 2432 KB  
Article
The Clinical Significance of the Early Screening of Keratoconus and Its Impact on Maintaining Quality of Life
by Mimoza Ismaili
Life 2026, 16(1), 124; https://doi.org/10.3390/life16010124 - 14 Jan 2026
Viewed by 693
Abstract
Background: This study focuses on the diagnosis and treatment of keratoconus in the early stage and aims to identify the environmental and risk factors that contribute to its progression. Methods: This retrospective investigation was carried out at the University Clinical Center of Kosovo [...] Read more.
Background: This study focuses on the diagnosis and treatment of keratoconus in the early stage and aims to identify the environmental and risk factors that contribute to its progression. Methods: This retrospective investigation was carried out at the University Clinical Center of Kosovo (UCCK) and comprised 131 patients newly diagnosed with keratoconus (KC). All procedures adhered to the Declaration of Helsinki, and the University of Pristina ethics committee approved this study before its initiation (Ref.Nr.104/2023). The confidentiality and anonymity of the surveyed patients were respected. The patients’ data consisted of gender, age, and race. Results: There were significant differences in the K1 distribution between groups, as the normal group (41.4 ± 0.5) was significantly lower than the suspect group (45.0 ± 3.2) and the degree of keratoconus (p < 0.001). There were significant differences in K2 between the groups, as the normal group (44.7 ± 5.1) was significantly lower than the suspect group (47.1 ± 2.8) and the other grades of keratoconus (p < 0.001). There were significant differences between groups regarding Kmax, as the normal group (44.5 ± 3.1) was significantly lower than the suspect group (46.9 ± 1.6) and the other grades of keratoconus (where p < 0.001). Statistically meaningful differences were detected between the groups with respect to subtlety, as the normal group (504.0 ± 27.6) was significantly higher than the suspect group (499.0 ± 48.1) and the other degrees of keratoconus (p < 0.001). Conclusions: Disease progression can significantly affect vision; therefore, early screening enables timely treatment (CXL). The evolution of this technique has contributed to preventing and slowing disease progression. Full article
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