Pharmacotherapy in Critical Care: Clinical Insight and Emerging Strategy

Dear Colleagues,

Pharmacotherapy plays a dynamic role in the management of critically ill patients, where rapid physiological changes and multiple organ dysfunction affect drug response and safety. Critically ill patients frequently experience deep physiological alterations that influence drug absorption, distribution, metabolism, and elimination. The complexity of intensive care medicine requires continuous adaption of pharmacological strategies to ensure efficacy while minimizing adverse effects. The increasing prevalence of multidrug-resistant infections, the complexity of sepsis management, and the increasing use of extracorporeal organ support require innovative and individualized therapeutic approches.

This Special Issue, “Pharmacotherapy in Critical Care: Clinical Insight and Emerging Strategy”, aims to provide an overview of clinical insight and emerging strategies in the pharmacological management of critical ill patients. We invite contributions that address pharmacokinetic and pharmacodynamic variability, drug optimization during organ support, immunomodulatory and anti-infective therapies, and the integration of precision medicine into clinical practice.

By bridging interdisciplinary collaboration among clinicians, pharmacologists and researchers, this Special Issue seeks to promote a multidisciplinary discussion and more personalized and effective pharmacotherapy for the critically ill population.

Prof. Dr. Caterina Aurilio
Guest Editor

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