Intracerebral Hemorrhage: Advances and Perspectives
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 25
Special Issue Editor
Interests: cerebral microhemorrhages
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The spectrum of cerebral hemorrhage is wide. The association between vascular risk factors and the progression of cerebral diseases remains partially unknown and has been the subject of many studies. Along with this, small vessel disorders are being better identified with the advancement of imaging technologies, especially magnetic resonance imaging (MRI).
From failures in the blood–brain barrier (BBB), which is the structure that regulates the transport of substances between the blood and the central nervous system, to morphofunctional dysfunctions, hemorrhages can present themselves in different ways.
The BBB, other than controling the entry of toxic substances and excess plasma hormones, also has an important role in the flow of blood cell elements. In this context, cerebral microhemorrhage (CMB) is a potential marker for the diagnosis and prognosis of cerebral damage. These focal deposits of hemosiderin indicate prior microhemorrhages around small vessels, and can be related to either ruptured atherosclerotic microvessels or amyloid angiopathy.
With more severe outcomes, intracerebral hemorrhage (ICH), in turn, is caused by bleeding within brain tissue itself, in a life-threatening type of stroke. Deprivation of oxygen and blood supply associated with ICH is most commonly caused by hypertension, arteriovenous malformations, or head trauma.
In addition to the previously mentioned pathophysiological disorders, cerebral hemorrhages can also be a reflection of morphoanatomical changes, such as microangiopathy. This microvessel disease, with small blood vessels in the microcirculation, also called microvascular dysfunction, microvascular disease, or small vessel disease (SVD), may be responsible for bleeding situations not necessarily related to biomolecular factors.
That said, this Special Issue of Life is intended to be a collection of reviews and original studies, containing up-to-date and innovative research on brain hemorrhages and their outcomes.
Dr. Ane Claudia Fernandes Nunes
Guest Editor
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Keywords
- intracerebral hemorrhage
- microangiopathic disease
- cerebral microhemorrhages blood–brain barrier
- small vessel disease
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