Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases
edited by Amosy Ephreim M’Koma
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4282 | Submission Open
Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment
(This special issue belongs to the Section Physiology and Pathology)
Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents
edited by Po-Jen Chen, and Shun-Hua Chen
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3041 | Submission Open
Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)
(This special issue belongs to the Section Pharmaceutical Science)
New Insights into Parkinson’s Disease: From Molecular Basis to Therapy submission deadline 30 Nov 2025 | 2 articles | Viewed by 2368 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; genes; GWAs; polygenic risk score; therapy; precision medicine; pathways; pharmacogenetics; surgicogenomics
(This special issue belongs to the Section Medical Research)
Pharmacokinetic and Pharmacogenetic Approaches in Personalized Medicine
edited by and Giuliana Abbadessa
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1042 | Submission Open
Keywords: pharmacogenetics; pharmacokinetics; sex; gender; drugs; personalization
(This special issue belongs to the Section Pharmaceutical Science)
Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 385 | Submission Open
Keywords: glioblastoma; chemotherapeutic resistance; glioblastoma stem cells; immunosuppression; brain– blood barrier
(This special issue belongs to the Section Physiology and Pathology)
Gender Medicine: Current Knowledge and Future Perspectives
edited by
submission deadline 30 Nov 2025 | Viewed by 270 | Submission Open
Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare
(This special issue belongs to the Section Medical Research)
New Horizons: Autoimmune-Related Thrombosis
edited by and
submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open
Keywords: chronic or transient autoantibodies; autoimmune thrombosis; lupus anticoagulant (LA); thrombotic thrombocytopenic Purpura (TTP); anti-phospholipid syndrome (APS); heparin induced thrombocytopenia/and thrombosis (HIT/HITT); vaccine induced thrombotic thrombocytopenia (VITT)
(This special issue belongs to the Section Medical Research)
Sports Biomechanics, Injury, and Physiotherapy
edited by Manos Stefanakis
submission deadline 30 Nov 2025 | Viewed by 90 | Submission Open
Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play
(This special issue belongs to the Section Physiology and Pathology)
Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-related Disease
edited by Laura Cianfruglia and
submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open
Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer
(This special issue belongs to the Section Physiology and Pathology)
Advanced Research in Exercise Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open
Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation
(This special issue belongs to the Section Physiology and Pathology)
Prostate Cancer: 4th Edition submission deadline 30 Nov 2025 | Viewed by 84 | Submission Open
Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling
(This special issue belongs to the Section Medical Research)
Total Joint Arthroplasty and Joint Replacement submission deadline 30 Nov 2025 | Viewed by 72 | Submission Open
Keywords: robotic and technology-assisted joint replacement; periprosthetic joint infection— prevention; diagnosis; and therapeutics; biomaterials and implant design; tissue engineering; muscle strengthening and conditioning; implant designs; edema and pain
(This special issue belongs to the Section Medical Research)
Pleural and Pulmonary Fibrosis: Pathogenesis and Possible Treatment Strategies
edited by Oluwaseun Adeyanju
submission deadline 30 Nov 2025 | Viewed by 66 | Submission Open
Keywords: pulmonary fibrosis; pleural fibrosis; pathogenesis; therapeutic strategies; inflammation
(This special issue belongs to the Section Physiology and Pathology)
Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases submission deadline 30 Nov 2025 | Viewed by 59 | Submission Open
Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery
(This special issue belongs to the Section Medical Research)
Advanced Research in Chronic Obstructive Pulmonary Disease: Physiology and Pathology
edited by
submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); biomarkers; inflammation; genomics; microbiome; air pollution
(This special issue belongs to the Section Medical Research)
Sleep and Sleep Apnea: Impacts, Mechanisms, and Interventions
edited by Yung-An Tsou and Wen-Dien Chang
submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open
Keywords: obstructive sleep apnea; sleep medicine; sleep surgery; sleep quality; insomnia
(This special issue belongs to the Section Physiology and Pathology)
Environment, Genetics, and Cardiovascular Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics
(This special issue belongs to the Section Medical Research)
Update on Obstructive Sleep Apnea (OSA) submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open
Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea
(This special issue belongs to the Section Physiology and Pathology)
Etiology, Diagnosis, and Treatment of Coeliac Diseases
edited by Paul J Ciclitira
submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open
Keywords: coeliac disease; blood tests; dietary treatment; etiology
(This special issue belongs to the Section Medical Research)
Coagulation and Its Disorders: Physiology and Pathological Mechanisms submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open
Keywords: coagulation; bleeding disorders; thrombotic mechanisms; animal models; molecular mechanisms; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammatory response; thrombin generation; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations
(This special issue belongs to the Section Physiology and Pathology)
Advances in Biomedical Frontier Technologies and Disease Diagnosis
edited by
submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open
Keywords: nanomedicine  ; biomaterials  ; gene therapy  ; drug delivery  ; bacteriotherapy  ; nanobiotechnology  ; hereditary diseases  ; bioinformatics  ; personalized medicine  ; smart biomaterials
(This special issue belongs to the Section Medical Research)
Endocrinology and Metabolic Syndrome: Epidemiology
edited by Roman Junik and
submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open
Keywords: metabolic syndrome; obesity; hypertension; diabetes; dyslipidemia; endocrinology
(This special issue belongs to the Section Epidemiology)
Prosthetic Joint Infections: A Multidisciplinary Approach
edited by
submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open
Keywords: orthoplastic approach; prosthetic joint infection; diagnosis and management of PJI; antibiotic therapy in periprosthetic infections
Innovative Cardiovascular Interventions: From Imaging to Precision Therapies submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open
Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies
(This special issue belongs to the Section Physiology and Pathology)
Advances in Millimeter-Wave-Based Pain Therapy
edited by and David Crouzier
submission deadline 30 Nov 2025 | Viewed by 8 | Submission Open
Keywords: millimetric waves; pain therapy; pain management; electromagnetic radiations; biophysics
Investigations of Circular RNAs in Plants submission deadline 1 Dec 2025 | Viewed by 49 | Submission Open
Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development
(This special issue belongs to the Section Plant Science)
Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation
edited by and Gelu Onose
submission deadline 2 Dec 2025 | 4 articles | Viewed by 4836 | Submission Open
Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions
(This special issue belongs to the Section Medical Research)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 253 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Unusual Genomic Traits in Their Evolutionary Context
edited by Miguel Naranjo-Ortiz
submission deadline 15 Dec 2025 | Viewed by 100 | Submission Open
Keywords: unusual genomes; genomic traits; comparative genomics; descriptive genomics; evolutionary genomics; non-model organisms; methodological limitations in genomics
(This special issue belongs to the Section Genetics and Genomics)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 17 Dec 2025 | 3 articles | Viewed by 1724 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origin of Life)
Innovative Approaches in Dermatological Therapies and Diagnostics submission deadline 26 Dec 2025 | 4 articles | Viewed by 2715 | Submission Open
Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Advances in Diagnostic Imaging for Systemic Disorders
edited by Christoph Strolz
submission deadline 29 Dec 2025 | Viewed by 72 | Submission Open
Keywords: high-resolution computed tomography (HRCT); diffusion-weighted imaging (DWI); dual-energy CT in musculoskeletal imaging; high-resolution ultrasonography; SPECT/CT; PET/CT modalities
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Current Views on Knee Osteoarthritis: 3rd Edition submission deadline 30 Dec 2025 | Viewed by 106 | Submission Open
Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine
(This special issue belongs to the Section Medical Research)
Advances in the Pathology of Dialysis: Insights into Peritoneal and Hemodialysis-Related Complications
edited by
submission deadline 30 Dec 2025 | Viewed by 19 | Submission Open
Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication
(This special issue belongs to the Section Physiology and Pathology)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 31 Dec 2025 | 21 articles | Viewed by 22921 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations
edited by
submission deadline 31 Dec 2025 | 15 articles | Viewed by 18235 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
New Trends in Otorhinolaryngology submission deadline 31 Dec 2025 | 6 articles | Viewed by 11434 | Submission Open
Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery
(This special issue belongs to the Section Medical Research)
Clinical Management and Prevention of Adverse Pregnancy Outcomes submission deadline 31 Dec 2025 | 5 articles | Viewed by 7275 | Submission Open
Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies
(This special issue belongs to the Section Reproductive and Developmental Biology)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6589 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics Through Small Mammal Monitoring and Research: 2nd Edition submission deadline 31 Dec 2025 | 7 articles | Viewed by 6279 | Submission Open
Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities
(This special issue belongs to the Section Diversity and Ecology)
Recent Advances in Functional Genomics
edited by Katerina R. Katsani and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4731 | Submission Open
Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics
(This special issue belongs to the Section Genetics and Genomics)
New Insights into Breast Cancer: Current Controversies and Future Perspectives
edited by , Angela Bucaro and Flavia de Lauretis
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4133 | Submission Open
Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition submission deadline 31 Dec 2025 | 3 articles | Viewed by 4028 | Submission Open
Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment
(This special issue belongs to the Section Medical Research)
Trends in Clinical Research 2025 submission deadline 31 Dec 2025 | 3 articles | Viewed by 2873 | Submission Open
Keywords: artificial intelligence; biomedical research; digital health; evidence-based medicine; health policy; new therapies; new drugs; patient-centered research; personalized medicine; translational medicine
(This special issue belongs to the Section Medical Research)
Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 31 Dec 2025 | 2 articles | Viewed by 2485 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
(This special issue belongs to the Section Medical Research)
Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition
edited by and Fang He
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1702 | Submission Open
Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1622 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Antimicrobial Innovations
edited by and Miho Nakamura
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1504 | Submission Open
Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety
(This special issue belongs to the Section Microbiology)
Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 1105 | Submission Open
Keywords: obstetrics; gynecology; translational research; translational medicine
(This special issue belongs to the Section Medical Research)
Feature Papers in Animal Science: 4th Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 782 | Submission Open
Keywords: fish; microbial ecology; lipid nutrition; electron microscopy; gut microbiota; proteomics; next-generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; Kunitz; tick; insect; vector– host interaction; innate immunity; shellfish immunology; bivalve molluscs; transcriptomics; diseases; hemocytes; microscopy
(This special issue belongs to the Section Animal Science)
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