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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity

edited by Elisa Na

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1111 | Submission Open

Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics

(This special issue belongs to the Section Physiology and Pathology)

Diagnosis and Treatment of Erectile Dysfunction

edited by

Geng-Long Hsu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 912 | Submission Open

Keywords: erectile dysfunction; non-invasive methods; surgical strategies

(This special issue belongs to the Section Physiology and Pathology)

Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment

edited by

Mengliang Zhang

and Hans Hultborn

submission deadline 31 Dec 2025 | 1 articles | Viewed by 762 | Submission Open

Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements

(This special issue belongs to the Section Medical Research)

Conservation Ecology and Management of Mammalian Predators

edited by

Sándor Csányi

and

Miklós Gábor Heltai

submission deadline 31 Dec 2025 | Viewed by 658 | Submission Open

Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions

(This special issue belongs to the Section Animal Science)

Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management

edited by

Yiwen Lin

and I-Han Hsiao

submission deadline 31 Dec 2025 | Viewed by 565 | Submission Open

Keywords: pain; mechanisms; signaling pathways; diagnosis

(This special issue belongs to the Section Physiology and Pathology)

Effects of Exercise and Functional Interventions on Musculoskeletal Health

edited by

Seong-Gil Kim

submission deadline 31 Dec 2025 | 2 articles | Viewed by 535 | Submission Open

Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science

(This special issue belongs to the Section Medical Research)

Advances in Artificial Intelligence for Medical Image Analysis: 2nd Edition

edited by

Xin Jin

submission deadline 31 Dec 2025 | 1 articles | Viewed by 430 | Submission Open

Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion

(This special issue belongs to the Section Medical Research)

Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges

edited by Pei-Ju Chao,

Tsair-Fwu Lee

Peter Elkin

and

Roberto Iezzi

submission deadline 31 Dec 2025 | Viewed by 424 | Submission Open

Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration

(This special issue belongs to the Section Medical Research)

The Interactions Between Cells and Their Microenvironment

edited by

Ping Yang

and

Haitao Nie

submission deadline 31 Dec 2025 | Viewed by 380 | Submission Open

Keywords: cell microenvironment; extracellular matrix; interstitial cells

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides

edited by

Yanchun Deng

and

Xiushi Yang

submission deadline 31 Dec 2025 | Viewed by 307 | Submission Open

Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging

(This special issue belongs to the Section Pharmaceutical Science)

Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease

edited by Anusha Vaddi

submission deadline 31 Dec 2025 | Viewed by 304 | Submission Open

Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology

(This special issue belongs to the Section Medical Research)

Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management

edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla

submission deadline 31 Dec 2025 | Viewed by 244 | Submission Open

Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides

(This special issue belongs to the Section Plant Science)

Move to Thrive: Pioneering Health and Resilience Through Physical Activity

edited by

Silvana Mirella Aliberti

Franca Di Meglio

and

Daria Nurzynska

submission deadline 31 Dec 2025 | Viewed by 210 | Submission Open

Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise

(This special issue belongs to the Section Physiology and Pathology)

Animal Reproduction and Health

edited by

Rachel Moxon

and

Ana Faustino

submission deadline 31 Dec 2025 | Viewed by 190 | Submission Open

Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development

(This special issue belongs to the Section Animal Science)

Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches

edited by Qinggang Zhu and Yaxiu Xu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 170 | Submission Open

Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches

(This special issue belongs to the Section Plant Science)

Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations

edited by Manuel Gil Lozano and Marina Romaní-Pérez

submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open

Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin

(This special issue belongs to the Section Physiology and Pathology)

Plant Adaptation Mechanisms to Abiotic Stresses

edited by Sunchung Park and Ezekiel Ahn

submission deadline 31 Dec 2025 | Viewed by 160 | Submission Open

Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors

(This special issue belongs to the Section Plant Science)

Bioactive Compounds for Medicine and Health

edited by

Christiana Charalambous

and

Alexandru Vasincu

submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open

Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection

(This special issue belongs to the Section Pharmaceutical Science)

Airway Management in Emergency and Intensive Care Medicine

edited by Prashant Nasa and Tonny V. Veenith

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment

(This special issue belongs to the Section Medical Research)

Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine

edited by

Ana Catarina Duarte

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice

edited by

Dimitris Tousoulis

submission deadline 31 Dec 2025 | Viewed by 130 | Submission Open

Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy

(This special issue belongs to the Section Medical Research)

The Biology and Functions of Platelets: Emerging Challenges

edited by

Robert Maitta

and Miriam Andrea Duque

submission deadline 31 Dec 2025 | Viewed by 117 | Submission Open

Keywords: platelet; hemostasis; toll-like receptor; immunity; phagocytosis; transfusions; von Willebrand factor; thrombocyte

(This special issue belongs to the Section Medical Research)

Origin of Life in Chemically Complex Messy Environments: 3rd Edition

edited by

Ranajay Saha

and

Alberto Vázquez-Salazar

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: origin of life; complex chemical systems ; prebiotic chemistry ; prebiotic metabolisms ; chemical evolution ; prebiotic catalysts

(This special issue belongs to the Section Origin of Life)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Leveraging the Power of Enzymes in Biotechnological Applications

edited by

Shengwei Sun

submission deadline 31 Dec 2025 | Viewed by 104 | Submission Open

Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application

Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition

edited by

and

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality

(This special issue belongs to the Section Plant Science)

Advancements in Heart Failure Research: 2nd Edition

edited by Tzu-Hurng Cheng,

Ju-Chi Liu

and

Po-Yuan Chen

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; patient-centered care; therapeutic innovations

(This special issue belongs to the Section Physiology and Pathology)

Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management

edited by

Anna Lisa Montemari

submission deadline 31 Dec 2025 | Viewed by 74 | Submission Open

Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

Traumatic Brain Injury: Epidemiology, Diagnosis, Treatment and Biomarkers

edited by

Jeff Victoroff

and

Alfredo Conti

submission deadline 31 Dec 2025 | Viewed by 72 | Submission Open

Keywords: traumatic brain injury; neurotrauma; epidemiology; rehabilitation; neurological disorders; biomarkers

(This special issue belongs to the Section Physiology and Pathology)

Understanding Brain Disorders Through EEG and AI

edited by Debashis Das Chakladar and

Giuseppe Augusto Chiarenza

submission deadline 31 Dec 2025 | Viewed by 68 | Submission Open

Keywords: EEG; ADHD; Alzheimer’ s; Parkinson’ s; neurological disorders; machine learning; deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities

edited by

Jun Noda

and

Daisuke Tanaka

submission deadline 31 Dec 2025 | Viewed by 65 | Submission Open

Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics

(This special issue belongs to the Section Microbiology)

Non-Conventional Approaches in Modern Biological Analysis and Medical Diagnostics

edited by

Anna Baraniak

and

Paweł Rudnicki-Velasquez

submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open

Keywords: biological samples; non-conventional analytical techniques; life science; diagnostics; proteins

Research Updates in Hematology

edited by

Eleni Gavriilaki

submission deadline 31 Dec 2025 | Viewed by 58 | Submission Open

Keywords: antiphospholipid syndrome; complement; endothelium; hemoglobinopathies; hemophilia; leukemias; lymphomas; multiple myeloma; pediatric hematology; thrombosis

(This special issue belongs to the Section Physiology and Pathology)

Research on Female Reproductive Health and Metabolism

edited by

Alice Bongrani

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: female reproduction; metabolism; nutrition; adipose tissue; hypothalamus– pituitary– gonadal axis; insulin resistance; adipocytokines; reproductive disorders; PCOS

(This special issue belongs to the Section Physiology and Pathology)

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 31 Dec 2025 | Viewed by 55 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

(This special issue belongs to the Section Medical Research)

Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition

edited by

Emma Borrelli

submission deadline 31 Dec 2025 | Viewed by 45 | Submission Open

Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species

(This special issue belongs to the Section Pharmaceutical Science)

Recent Advances in Left Ventricular Unloading Therapy

edited by Mehmet Oezkur

submission deadline 31 Dec 2025 | Viewed by 45 | Submission Open

Keywords: left ventricular unloading therapy; cardiovascular medicine; heart failure; acute myocardial infarction

(This special issue belongs to the Section Medical Research)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 31 Dec 2025 | Viewed by 38 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Update on Clinical Pharmacology

edited by

Ju-Seop Kang

submission deadline 31 Dec 2025 | Viewed by 18 | Submission Open

Keywords: drug efficacy and drug safety; new drug development; therapeutic drug monitoring; clinical trials; pharmacodynamic and pharmacokinetics; pharmacovigilance; clinical toxicology

(This special issue belongs to the Section Pharmaceutical Science)

Topographical Anatomy and Physiological Mechanics of the Musculoskeletal System

edited by

Michael L. Pretterklieber

submission deadline 31 Dec 2025 | Viewed by 4 | Submission Open

Keywords: muscle; bone; joint; peripheral nerve; motor innervation; proprioception; anatomical variant; radiologic imaging; development; comparative anatomy

(This special issue belongs to the Section Medical Research)

Early Prebiotic Reaction Networks

edited by Olga Taran and Paul J. Bracher

submission deadline 31 Dec 2025 | Viewed by 1 | Submission Open

Keywords: thioesters; autocatalytic reactions; redox cycling; chemical fossils; TCA cycle analogues

(This special issue belongs to the Section Origin of Life)

Human Infertility and Reproductive Endocrinology: 2nd Edition

edited by

Giuseppe Grande

submission deadline 6 Jan 2026 | 3 articles | Viewed by 3959 | Submission Open

Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility

(This special issue belongs to the Section Reproductive and Developmental Biology)

Innovations in Dairy Cattle Health and Nutrition Management

edited by Rasa Želvytė and Ingrida Monkevičienė

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers

(This special issue belongs to the Section Animal Science)

Research Progress in Kidney Diseases

edited by Ane Claudia Fernandes Nunes

submission deadline 15 Jan 2026 | Viewed by 225 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics

(This special issue belongs to the Section Physiology and Pathology)

Biological Context of Life in the Middle East and North Africa

edited by

Kanya Godde

submission deadline 15 Jan 2026 | Viewed by 73 | Submission Open

Keywords: biodiversity in the Middle East; biodiversity in North Africa; population genetics in the Middle East; ecology in the Middle East; ecology in North Africa; skeletal variation in the Middle East; skeletal variation in North Africa; dental variation in the Middle East; dental variation in North Africa

New Insights into Allergic Eye Diseases

edited by

De Gaulle I. Chigbu

and

Livio Vitiello

submission deadline 16 Jan 2026 | 2 articles | Viewed by 13721 | Submission Open

Keywords: allergy; IgE; IL-4; IL-5; IL-13; TNF-alpha; mast cells; eosinophils; Th1 cells; Th2 cells; therapeutics; immunopathogenesis; immunopathology; conjunctivitis; keratoconjunctivitis

(This special issue belongs to the Section Medical Research)

Multi-Omics Approaches for Gut Microbiota Research: Implications for Human Nutrition

edited by

Georgia Saxami

and Antonio Benedetti

submission deadline 16 Jan 2026 | Viewed by 466 | Submission Open

Keywords: gut microbiota; multi-omics; metagenomics; metabolomics; host– microbiome interactions; precision nutrition; dietary interventions

(This special issue belongs to the Section Microbiology)

Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine

edited by

Adrian Neagu

submission deadline 18 Jan 2026 | 2 articles | Viewed by 3805 | Submission Open

Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Advances in Vascular Health and Metabolism

edited by Ana Blazquez-Medela

submission deadline 18 Jan 2026 | 2 articles | Viewed by 1585 | Submission Open

Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease

(This special issue belongs to the Section Medical Research)

Knee Bracing in Human Movement: Biomechanics, Artificial Intelligence, and Optimization

edited by

Zixiang Gao

and Liangliang Xiang

submission deadline 20 Jan 2026 | Viewed by 89 | Submission Open

Keywords: knee bracing; sports biomechanics; neuromechanical mechanisms; gait analysis; functional movement adaptation; AI in orthotics; AI for brace performance; musculoskeletal modeling; finite element simulation; real-time monitoring of knees; human-in-the-loop control; robotic exoskeleton integration; human– machine interaction; rehabilitation or injury prevention

(This special issue belongs to the Section Medical Research)

Displaying special issue 301-350 on page 7 of 10.

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