Myeloproliferative Neoplasms: From Biology to Practice
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 9
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue, “Myeloproliferative Neoplasms: From Biology to Practice”, aims to address key unmet needs in the diagnosis, risk stratification, and management of classic BCR::ABL1‑negative myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia, and myelofibrosis. Despite major advances in molecular profiling and targeted therapies, many patients continue to face significant symptom burdens, thrombotic and hemorrhagic complications, clonal evolution, and reduced survival, underscoring the need for better translational and clinical strategies.
The objective of this Special Issue is to highlight knowledge gaps and research priorities across the MPN continuum, from disease initiation and clonal architecture to the progression to myelofibrosis or acute leukemia. We welcome original research, clinical trials, real‑world data, translational and basic science studies, as well as state‑of‑the‑art reviews. Topics of interest include molecular pathogenesis, novel prognostic models, symptom assessment and patient‑reported outcomes, innovative therapeutic approaches (including combinations and next‑generation agents), and long‑term outcomes after allogeneic transplantation or disease‑modifying interventions. Studies on health economics, survivorship, and education or training initiatives in MPN care are also encouraged, with a view to informing practice and guiding future research in this rapidly evolving field.
Dr. Adrian Duek
Guest Editor
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Keywords
- polycythemia vera
- essential thrombocythemia
- primary myelofibrosis
- JAK2 V617F calreticulin
- MPL
- next-generation sequencing
- risk factor scores
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