Machine Learning for Biomedical and Clinical Informatics: From Data-Driven Methods to Translational Medical Research

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 299

Editors


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Guest Editor
School of Information, Florida State University, Tallahassee, FL, USA
Interests: biomedical informatics; clinical data science; electronic health records; machine learning; natural language processing; large language models; causal inference
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biomedical Informatics and Data Science, School of Medicine, Yale University, New Haven, CT, USA
Interests: natural language processing; machine learning; deep learning; gpt; bioinformatics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in machine learning (ML) and artificial intelligence (AI) are rapidly transforming biomedical and clinical informatics by enabling scalable analysis of complex, high-dimensional health data. This Special Issue focuses on methodological innovations and real-world applications of ML and AI that advance medical research, clinical decision-making, and population health. Emphasis is placed on informatics-driven approaches that integrate heterogeneous data sources, including electronic health records (EHRs), clinical narratives, biomedical literature, medical imaging, laboratory results, genomics, and other multi-omics data.

We invite original research, reviews, and methodological studies addressing both foundational and applied aspects of biomedical and clinical informatics. Topics of interest include, but are not limited to, predictive modeling, deep learning, natural language processing, large language models, causal inference, explainable AI, and fairness-aware modeling in healthcare. Studies demonstrating translational impact, such as improving diagnosis, prognosis, treatment selection, risk stratification, clinical workflow optimization, and patient-centered decision support, are particularly encouraged.

This Special Issue aims to bridge the gap between algorithmic development and clinical utility by highlighting reproducible, interpretable, and ethically responsible ML approaches. By bringing together interdisciplinary perspectives from informatics, medicine, data science, and public health, this Special Issue seeks to advance the responsible adoption of AI-driven methods in biomedical and clinical research.

Dr. Balu Bhasuran
Dr. Kalpana Raja
Guest Editors

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Keywords

  • biomedical informatics
  • translational medical research
  • clinical informatics
  • causal inference in health data
  • machine learning in healthcare
  • electronic health records (EHR)
  • natural language processing
  • large language models
  • artificial intelligence in medicine
  • explainable and trustworthy AI

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Published Papers (1 paper)

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Research

23 pages, 7222 KB  
Article
A Wearable Infrared Sensor for Detecting Non-ST Segment Elevation Acute Coronary Syndromes
by Partho P. Sengupta, Ankush D. Jamthikar, Naveena Yanamala, Kameswari Maganti, Jitto Titus, Sanjeev P. Bhavnani, Lori B. Daniels, William F. Peacock and Shantanu Sengupta
Life 2026, 16(7), 1155; https://doi.org/10.3390/life16071155 - 13 Jul 2026
Abstract
Background: Non-ST segment elevation acute coronary syndrome (NSTE-ACS) is conventionally diagnosed using electrocardiography and serial blood biomarker measurements. We investigated a noninvasive, bloodless, and electrode-free diagnostic strategy using a wrist-worn infrared spectrophotometric biosensor (Infrasensor). Results: In a prospective multicenter study of 595 patients [...] Read more.
Background: Non-ST segment elevation acute coronary syndrome (NSTE-ACS) is conventionally diagnosed using electrocardiography and serial blood biomarker measurements. We investigated a noninvasive, bloodless, and electrode-free diagnostic strategy using a wrist-worn infrared spectrophotometric biosensor (Infrasensor). Results: In a prospective multicenter study of 595 patients with suspected NSTE-ACS enrolled across 13 sites in two countries, participants were stratified into five analytical cohorts. With 200 multi-ethnic controls and a leave-one-cohort-out external validation, a machine learning model detected high-grade coronary obstruction with an area under the receiver operating characteristic curve (AUC) of 0.87 (95% CI: 0.84–0.90), 90% specificity, and 84% positive predictive value—surpassing standard risk scores. A secondary model predicted freedom from NSTE-ACS and adverse outcomes over 30 days with an AUC of 0.89 (95% CI: 0.87–0.92), 99% sensitivity, and 96% negative predictive value. Conclusions: The Infrasensor demonstrated high diagnostic accuracy for high-grade coronary obstruction and 30-day adverse outcome prediction, surpassing conventional risk scores across a prospective, multi-ethnic, multicenter cohort. These findings support its potential as a rapid, noninvasive point-of-care tool for early NSTE-ACS risk stratification. Full article
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