Innovations in Critical Care and Anesthesiology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 2 October 2026 | Viewed by 122

Special Issue Editor

Special Issue Information

Dear Colleagues,

Critical care and anesthesiology have undergone remarkable transformations in recent years, driven by technological advances, evolving clinical protocols, and lessons learned from global health challenges. This Special Issue aims to showcase cutting-edge innovations that are reshaping perioperative medicine and intensive care practice.

We invite contributions exploring novel monitoring technologies, artificial intelligence applications in critical care decision-making, advanced ventilation strategies, and personalized approaches to sedation and analgesia. Papers addressing point-of-care diagnostics, enhanced recovery protocols, organ support innovations, and telemedicine applications in ICU settings are particularly welcome. We also encourage submissions on emerging pharmacological agents, non-invasive monitoring techniques, and quality improvement initiatives that enhance patient safety and outcomes.

This collection seeks to bridge the gap between technological innovation and clinical implementation, highlighting translational research that directly impacts patient care. We welcome original research articles, comprehensive reviews, case studies demonstrating novel techniques, and perspective pieces on future directions in the field. By bringing together diverse perspectives from clinicians, researchers, and biomedical engineers, this Special Issue aims to provide a comprehensive overview of the current landscape and future horizons in critical care and anesthesiology.

Dr. Luigi La Via
Guest Editor

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Keywords

  • artificial intelligence in ICU
  • point-of-care monitoring
  • enhanced recovery protocols
  • precision anesthesia
  • mechanical ventilation
  • organ support systems
  • perioperative medicine
  • critical care innovations

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Published Papers (1 paper)

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Research

16 pages, 1462 KB  
Article
Fluid Creep as an Independent Predictor of Fluid Overload and Mortality in Critically Ill Patients: A Cohort Study
by George Briassoulis, Theodora Antonopoulou, Joanna Velegraki, Stavroula Ilia and Eumorfia Kondili
Life 2025, 15(12), 1900; https://doi.org/10.3390/life15121900 - 12 Dec 2025
Abstract
Background: Fluid overload (FO) is a frequent ICU complication and an important predictor of adverse outcomes. While classically attributed to resuscitative fluids, recent data emphasize the contribution of non-therapeutic “fluid creep” from medication diluents and carrier infusions. This study examined associations between fluid [...] Read more.
Background: Fluid overload (FO) is a frequent ICU complication and an important predictor of adverse outcomes. While classically attributed to resuscitative fluids, recent data emphasize the contribution of non-therapeutic “fluid creep” from medication diluents and carrier infusions. This study examined associations between fluid creep, FO, acute kidney injury (AKI), and mortality, and explored the predictive value of the modified Renal Angina Index (mRAI) for AKI risk stratification and FO; Methods: A retrospective cohort of 250 critically ill adults (ICU stay ≥72 h) admitted to a mixed medical–surgical ICU between May 2021 and November 2024 was analyzed. All fluids administered during the first 72 h were categorized and indexed to ideal body weight. Fluid creep included drug diluents, carriers, and flushes. FO% was calculated as [(Cumulative Fluid Balance)/IBW] × 100; Results: Fluid creep was higher in non-survivors (5183 ± 2541 vs. 4354 ± 2171 mL; p = 0.008) and correlated with FO, cumulative balance, and total input (r = 0.41 to 0.43; p < 0.001). Creep and FO independently predicted ICU mortality. Abnormal mRAI scores were associated with FO and early AKI; Conclusions: Fluid creep and FO were independent mortality predictors. Routine monitoring and minimization of creep, along with structured de-resuscitation protocols, may improve outcomes in critically ill adults. Full article
(This article belongs to the Special Issue Innovations in Critical Care and Anesthesiology)
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