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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Psychological Pain and Suicidal Behavior: Clinical Implications
edited by Adrián Alacreu-Crespo
submission deadline 25 Dec 2025 | Viewed by 41 | Submission Open
Keywords: suicidal behavior; psychological pain; pain tolerance; therapeutic interventions; clinical outcomes
(This special issue belongs to the Section Mental Health)
IgA Nephropathy: Clinical Updates and Prospects
edited by
submission deadline 25 Dec 2025 | Viewed by 38 | Submission Open
Keywords: pathogenesis of IgA nephropathy; novel therapies; role of complement system; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification
(This special issue belongs to the Section Nephrology & Urology)
Myocardial Infarction: Clinical Management and Future Options
edited by
submission deadline 25 Dec 2025 | Viewed by 35 | Submission Open
Keywords: myocardial infarction; percutaneous coronary intervention; optimal medical therapy; clinical outcomes; cardiogenic shock; mechanical cardiac support device
(This special issue belongs to the Section Cardiology)
Advances and Innovations in Hand Surgery
edited by David L. Colen, Jason Wink and Anthony Archual
submission deadline 25 Dec 2025 | Viewed by 34 | Submission Open
Keywords: hand surgery; peripheral nerve surgery; shared decision making; microsurgery; arthritis; compression neuropathy; carpal tunnel; cubital tunnel
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Innovations and Future Directions in Valvular Heart Disease: Imaging, Technology, and Translational Research
edited by , Muhammed Gerçek and Felix Rudolph
submission deadline 25 Dec 2025 | Viewed by 27 | Submission Open
Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis; minimally invasive surgery; concomitant valve disease
(This special issue belongs to the Section Cardiology)
Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders
edited by and Jakub Baran
submission deadline 25 Dec 2025 | Viewed by 24 | Submission Open
Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy
(This special issue belongs to the Section Cardiology)
Advances in Anterior Segment Surgery: Second Edition
edited by
submission deadline 25 Dec 2025 | Viewed by 21 | Submission Open
Keywords: lenticule-based surgery; surface ablations; blended vision treatments with laser refractive surgery; corneal inlay procedures; presbyopia management with monovision laser vision correction; refractive lens exchange; premium presbyopia-correcting intraocular lens; refractive solutions for keratoconics; cataract surgery; corneal transplant; biometry
(This special issue belongs to the Section Ophthalmology)
New Insights in Skin Tumors: From Pathogenesis to Therapy
edited by Loredana Ungureanu and Simona C. Şenilǎ
submission deadline 25 Dec 2025 | Viewed by 14 | Submission Open
Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology
(This special issue belongs to the Section Dermatology)
Multifactorial Causation and Therapies of Myopia: 2nd Edition submission deadline 26 Dec 2025 | Viewed by 26 | Submission Open
Keywords: epidemiology; genetics; premyopia; simple and pathological myopia; orthokeratology; lenses for myopia control; blue light and red light; binocular vision and ocular optics; artificial intelligence
(This special issue belongs to the Section Ophthalmology)
Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases submission deadline 28 Dec 2025 | Viewed by 35 | Submission Open
Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research
(This special issue belongs to the Section Ophthalmology)
Current Concepts and Clinical Application of Echocardiography
edited by
submission deadline 29 Dec 2025 | Viewed by 36 | Submission Open
Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology
(This special issue belongs to the Section Cardiology)
Managements of Venous Thromboembolism submission deadline 29 Dec 2025 | Viewed by 15 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Cerebral Palsy: Recent Advances in Clinical Management
edited by Laurie J. Glader and M. Wade Shrader
submission deadline 30 Dec 2025 | Viewed by 347 | Submission Open
Keywords: cerebral palsy; pediatric; neurology; complex care; clinical management
(This special issue belongs to the Section Clinical Pediatrics)
Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction
edited by
submission deadline 30 Dec 2025 | Viewed by 90 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes
(This special issue belongs to the Section Anesthesiology)
Advancements in Emergency Medicine Practices and Protocols
edited by Vincenzo G. Menditto and Beatrice Gasperini
submission deadline 30 Dec 2025 | Viewed by 49 | Submission Open
Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit
(This special issue belongs to the Section Emergency Medicine)
Plastic and Reconstructive Surgery of the Face: Chances and Challenges
edited by and Bogdan Andrei Suciu
submission deadline 30 Dec 2025 | Viewed by 47 | Submission Open
Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice
edited by Mattia Algeri
submission deadline 30 Dec 2025 | Viewed by 41 | Submission Open
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship
(This special issue belongs to the Section Hematology)
Pulmonary Critical Care: Integrating Bedside Physiology and Advanced Monitoring in the Management of Severe Respiratory Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 41 | Submission Open
Keywords: lung monitoring; ARDS; ARF; biomarkers; lung physiology; pneumonia; lung ultrasound; artificial intelligence; COPD; EIT
(This special issue belongs to the Section Respiratory Medicine)
Interventional Cardiology: Recent Developments and Future Challenges
edited by Andreas Mitsis and George Kassimis
submission deadline 30 Dec 2025 | Viewed by 38 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Joint Repair and Replacement: Current Challenges and Opportunities
edited by Bartosz Gonera and Kacper Ruzik
submission deadline 30 Dec 2025 | Viewed by 34 | Submission Open
Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants
(This special issue belongs to the Section Orthopedics)
Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance
edited by Radu Andy Sascau and
submission deadline 30 Dec 2025 | Viewed by 34 | Submission Open
Keywords: cardiac magnetic resonance; cardiomyopathy; tissue characterization; stress perfusion; 4D flow; heart failure; ischemic heart disease; multi-modality imaging; valvular heart disease; T1 mapping; T2 mapping; myocarditis
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Management for Coronary Artery Disease and Revascularization
edited by Mohammad Reza Movahed
submission deadline 30 Dec 2025 | Viewed by 32 | Submission Open
Keywords: coronary artery disease; coronary syndrome; stenting; revascularization; cardiovascular
(This special issue belongs to the Section Cardiovascular Medicine)
Challenges and Opportunities in Colorectal Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 29 | Submission Open
Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 30 Dec 2025 | Viewed by 29 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | Viewed by 28 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology)
Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application
edited by and Alexandros Daponte
submission deadline 30 Dec 2025 | Viewed by 28 | Submission Open
Keywords: ultrasound-guided biopsy; gynecologic tumors; ovarian cancer; biopsy technique; precision diagnosis; endometrial lesions
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Antiphospholipid Syndrome (APS)
edited by
submission deadline 30 Dec 2025 | Viewed by 28 | Submission Open
Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies
(This special issue belongs to the Section Immunology)
Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies
edited by
submission deadline 30 Dec 2025 | Viewed by 25 | Submission Open
Keywords: endometriosis; ovarian endometrioma; polycystic ovary syndrome; reproductive health; cervical; postmenopausal women; hormone replacement therapy; sarcopenia
(This special issue belongs to the Section Obstetrics & Gynecology)
Shoulder Arthroplasty: Clinical Advance and Future Perspective
edited by Vani J. Sabesan
submission deadline 30 Dec 2025 | Viewed by 19 | Submission Open
Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes
(This special issue belongs to the Section Orthopedics)
Cutting-Edge Technologies and Unconventional Therapies in Heart Failure
edited by and Pablo Díez-Villanueva
submission deadline 30 Dec 2025 | Viewed by 15 | Submission Open
Keywords: heart failure; new technologies; artificial intelligence; treatment; advanced heart failure
(This special issue belongs to the Section Cardiology)
Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions
edited by Cosmin Sinescu, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 9727 | Submission Open
Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 31 Dec 2025 | Viewed by 1279 | Submission Open
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Acute Kidney Injury: Latest Advances and Prospects
edited by and Kianoush Kashani
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1258 | Submission Open
Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach
(This special issue belongs to the Section Nephrology & Urology)
Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine submission deadline 31 Dec 2025 | 1 articles | Viewed by 407 | Submission Open
Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 31 Dec 2025 | Viewed by 112 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | Viewed by 101 | Submission Open
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 83 | Submission Open
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | Viewed by 72 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Orthopedic Oncology Updates and Controversial Issues
edited by Yehuda Kollender and Ron Batash
submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy
(This special issue belongs to the Section Orthopedics)
Innovations in Psychosis and Schizophrenia: New Findings and Implications
edited by
submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open
Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions
(This special issue belongs to the Section Mental Health)
Oral Health and Dental Care: Current Advances and Future Options
edited by , and Alessia Bramanti
submission deadline 31 Dec 2025 | Viewed by 46 | Submission Open
Keywords: oral health; dental care; technologies; innovation; dental materials
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | Viewed by 45 | Submission Open
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives submission deadline 31 Dec 2025 | Viewed by 40 | Submission Open
Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery
(This special issue belongs to the Section Respiratory Medicine)
The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open
Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine
(This special issue belongs to the Section Cardiovascular Medicine)
Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health
edited by and Anne-Marie Iselin
submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open
Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms
(This special issue belongs to the Section Mental Health)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | Viewed by 31 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 31 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 30 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Paradigms, Advances and Future Directions in Oral Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 25 | Submission Open
Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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