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Journal of Clinical Medicine, Volume 14, Issue 13

July-1 2025 - 424 articles

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Cover Story: Venous thromboembolism (VTE) is a major source of preventable morbidity in neurocritically ill patients, yet the optimal timing and agent for pharmacologic thromboprophylaxis (PTP) remain uncertain. In this review of 90 studies, including 669,725 patients with traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or spinal cord injury, or those requiring neurosurgical intervention, early PTP (within 24–72 hours) was generally associated with reduced VTE risk without a consistently increased risk of bleeding. Enoxaparin showed potential benefits over unfractionated heparin in certain subgroups. Safety may be improved in some injury types, with early repeat imaging suggesting stable bleeding. Despite variability in study designs and quality, this updated assessment of the literature supports early, individualized PTP strategies. View this paper

Articles (424)

  • Article
  • Open Access
2,988 Views
12 Pages

Ophthalmic Artery Doppler Indices at 11–13 Weeks of Gestation in Relation to Early and Late Preeclampsia

  • Nicoleta Gana,
  • Savia Pittokopitou,
  • Filippos Solonos,
  • Alina Perdeica,
  • Marina Fitiri and
  • Kypros H. Nicolaides

7 July 2025

Background/Objective: Preeclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. Early prediction is crucial for timely intervention and management. The ophthalmic artery (OA) Doppler assessment in the first trimester ha...

  • Article
  • Open Access
1,179 Views
14 Pages

Comparison of Validity and Reliability of Manual Consensus Grading vs. Automated AI Grading for Diabetic Retinopathy Screening in Oslo, Norway: A Cross-Sectional Pilot Study

  • Mia Karabeg,
  • Goran Petrovski,
  • Katrine Holen,
  • Ellen Steffensen Sauesund,
  • Dag Sigurd Fosmark,
  • Greg Russell,
  • Maja Gran Erke,
  • Vallo Volke,
  • Vidas Raudonis and
  • Rasa Verkauskiene
  • + 4 authors

7 July 2025

Background: Diabetic retinopathy (DR) is a leading cause of visual impairment worldwide. Manual grading of fundus images is the gold standard in DR screening, although it is time-consuming. Artificial intelligence (AI)-based algorithms offer a faster...

  • Article
  • Open Access
1 Citations
1,403 Views
13 Pages

7 July 2025

Background: Emotional dysregulation (ED) is a transdiagnostic feature of multiple adolescent psychiatric disorders and a predictor of functional impairment and self-harming behaviors. Despite its clinical relevance, pharmacological treatments targeti...

  • Systematic Review
  • Open Access
1 Citations
3,688 Views
15 Pages

7 July 2025

Background/Objectives: Robotic-assisted gait training (RAGT) is a promising adjunct to conventional rehabilitation for stroke survivors. However, its additive benefit over standard therapy remains to be fully clarified. This systematic review and met...

  • Article
  • Open Access
662 Views
10 Pages

7 July 2025

Background: Klippel–Trenaunay syndrome (KTS) is a congenital vascular malformation syndrome characterized by low-flow vascular anomalies, including venous malformation (VM) and lymphatic involvement. These anomalies may lead to limb asymmetry d...

  • Review
  • Open Access
1,931 Views
20 Pages

7 July 2025

Oncoplastic breast-conserving surgery (OBCS), or oncoplastic surgery, has revolutionized the surgical management of breast cancer by integrating oncologic principles with reconstructive techniques to optimize both cancer control and aesthetic outcome...

  • Review
  • Open Access
886 Views
16 Pages

7 July 2025

Aberrant activation of Wnt/β-catenin signaling, frequently caused by oncogenic mutations, plays a crucial role in the development, progression, and therapy resistance of gastric, esophageal, hepatic, pancreatic, and colorectal cancers. Concurren...

  • Systematic Review
  • Open Access
1 Citations
1,396 Views
33 Pages

Pregestational Diabetes Mellitus and Adverse Perinatal Outcomes: A Systematic Review and Meta-Analysis

  • Dionysios Gazis,
  • Antigoni Tranidou,
  • Antonios Siargkas,
  • Aikaterini Apostolopoulou,
  • Georgia Koutsouki,
  • Dimitrios G. Goulis,
  • Christos Tsakalidis,
  • Ioannis Tsakiridis and
  • Themistoklis Dagklis

7 July 2025

Background/Objectives: As the incidence of diabetes mellitus (DM) is increasing rapidly worldwide, it is anticipated that an increasing number of women will enter pregnancy with pregestational diabetes mellitus (PGDM) in the future. Compelling eviden...

  • Article
  • Open Access
1 Citations
943 Views
14 Pages

Impact of RSV Infection in Transplant and Immunocompromised Population: Incidence and Co-Infections: Retrospective Analysis of a Single Centre

  • Paolo Solidoro,
  • Antonio Curtoni,
  • Sara Minuto,
  • Nour Shbaklo,
  • Francesco Giuseppe De Rosa,
  • Alessandro Bondi,
  • Francesca Sidoti,
  • Filippo Patrucco,
  • Elisa Zanotto and
  • Silvia Corcione
  • + 4 authors

7 July 2025

Respiratory syncytial virus (RSV) represents one of the main respiratory infections found among immunocompromised patients. Objective: The study analyzes the incidence of RSV infection in different populations of immunocompromised patients as organ t...

  • Article
  • Open Access
1,161 Views
14 Pages

Hepatic Artery Thrombosis After Orthotopic Liver Transplant: A 20-Year Monocentric Series

  • Vincenzo Tondolo,
  • Gianluca Rizzo,
  • Giovanni Pacini,
  • Luca Emanuele Amodio,
  • Federica Marzi,
  • Giada Livadoti,
  • Giuseppe Quero and
  • Fausto Zamboni

7 July 2025

Background/Objectives: Hepatic artery thrombosis (HAT) is a serious vascular complication in patients undergoing orthotopic liver transplantation (OLT). It is associated with a high risk of graft loss, re-transplantation (re-OLT), and mortality. This...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license