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Myocarditis and Pericarditis: Clinical Advances and Current Challenges
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Myocarditis and Pericarditis: Clinical Advances and Current Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 1708

Editors

Dr. Ankit Agrawal

E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA
Interests: myocarditis; pericarditis; intracardiac thrombus; aortic stenosis; machine learning
Dr. Tom Kai Ming Wang

E-Mail Website
Guest Editor
Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA
Interests: cardiovascular Imaging; valvular heart disease; coronary heart disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pericarditis and myocarditis are at the forefront of cardiovascular research and clinical attention. These inflammatory cardiac conditions span a diverse range of etiologies—from idiopathic and viral to autoimmune and immune-mediated causes, including those related to cancer immunotherapies. Despite increased recognition, significant diagnostic and management challenges remain.

This Special Issue is dedicated to exploring the clinical advances and persistent challenges in the fields of pericarditis and myocarditis. It brings together a curated collection of original studies, comprehensive reviews, and expert insights addressing key developments in diagnosis, risk stratification, imaging, and treatment strategies. We delve into the evolving role of multimodal imaging, novel treatments, and a multidisciplinary approach towards the management of these complex diseases.

The issue aims to provide clinicians, researchers, and trainees with an updated, practical framework to approach these conditions while also highlighting gaps in evidence and areas needing further investigation. We hope the content will foster greater awareness, early recognition, and multidisciplinary management to improve patient outcomes.

Dr. Ankit Agrawal
Dr. Tom Kai Ming Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pericarditis
  • myocarditis
  • pericardial effusion
  • cardiac tamponade
  • interleukin-1 inhibitors
  • pericardium

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Published Papers (1 paper)

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Review

18 pages, 1221 KB  
Review
Contemporary Review of Clinical Features, Multi-Modality Imaging, and Management of Pericardial Cysts
by Ankit Agrawal, Mohab Elnashar, Keshav Garg, Ahmad Mustafa, Akiva Rosenzveig, Aro Daniela Arockiam, Elio Haroun, Rishabh Khurana, Allan L. Klein and Tom Kai Ming Wang
J. Clin. Med. 2026, 15(4), 1585; https://doi.org/10.3390/jcm15041585 - 18 Feb 2026
Viewed by 1287
Abstract
Pericardial cysts (PCs) are rare, benign congenital abnormalities that are encountered as mediastinal lesions. Despite their rarity, they remain clinically important due to their potential to mimic other mediastinal or cardiac pathologies and their capacity, in select cases, to cause significant complications. PCs [...] Read more.
Pericardial cysts (PCs) are rare, benign congenital abnormalities that are encountered as mediastinal lesions. Despite their rarity, they remain clinically important due to their potential to mimic other mediastinal or cardiac pathologies and their capacity, in select cases, to cause significant complications. PCs are typically identified incidentally on imaging studies such as chest x-ray or transthoracic echocardiography, as most patients remain asymptomatic throughout their lives. When symptoms do occur, they are often nonspecific and related to compression of adjacent structures. Serious complications—including infection, rupture, and, rarely, cardiac tamponade—have been reported, underscoring the importance of accurate diagnosis and appropriate follow-up. Definitive characterization of PCs is best achieved using advanced imaging modalities such as cardiac computed tomography or cardiac magnetic resonance imaging, which help differentiate PCs from other mediastinal masses. While many PCs remain stable or even regress spontaneously, intervention may be warranted for symptomatic patients, enlarging cysts, or when the diagnosis remains uncertain. Therapeutic options include percutaneous aspiration, which carries a risk of recurrence, and surgical resection, which offers definitive treatment with excellent outcomes. This review provides a comprehensive overview of the etiology, clinical manifestations, diagnostic evaluation, differential diagnosis, complications, and management strategies for PCs. Full article
(This article belongs to the Special Issue Myocarditis and Pericarditis: Clinical Advances and Current Challenges)
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