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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mind–Body Connection: The Impact of Mental Health on Physical Well-Being

edited by

Mario Pinto

submission deadline 30 Jan 2026 | Viewed by 175 | Submission Open

Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare

(This special issue belongs to the Section Mental Health)

Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes

edited by

Damiano Caputo

Roberto Cammarata

and Federica Giordano

submission deadline 30 Jan 2026 | Viewed by 114 | Submission Open

Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile

(This special issue belongs to the Section Oncology)

Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs

edited by

Silvius Alexandru Pescariu

Felix Bratosin

and

Cristian Mornos

submission deadline 30 Jan 2026 | Viewed by 88 | Submission Open

Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care

(This special issue belongs to the Section Cardiology)

Clinical Outcomes in Bipolar and Depressive Disorders

edited by

Luca J. Steardo

and Francesco Monaco

submission deadline 30 Jan 2026 | Viewed by 75 | Submission Open

Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology

(This special issue belongs to the Section Mental Health)

Current Advances in General and Regional Anesthesia

edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi

submission deadline 30 Jan 2026 | Viewed by 56 | Submission Open

Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety

(This special issue belongs to the Section Anesthesiology)

Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends

edited by Michail Pitiakoudis

submission deadline 30 Jan 2026 | Viewed by 52 | Submission Open

Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology

(This special issue belongs to the Section General Surgery)

Clinical Management, Diagnosis and Treatment of Thoracic Diseases: 2nd Edition

edited by

Damiano D’Ardes

and

Andrea Boccatonda

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1358 | Submission Open

Keywords: lung; thorax; pneumonia; chest; imaging; ultrasound

(This special issue belongs to the Section Respiratory Medicine)

Diagnosis and Treatment of Obstetrics and Gynecology Cancers

edited by

Gaspare Cucinella

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1320 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radio-therapy; systemic treatment; immunotherapy; sentinel lymph node biopsy; minimally invasive surgery; fertility preservation; gestational trophoblastic disease

(This special issue belongs to the Section Obstetrics & Gynecology)

Thoracic Surgery: Updates and New Trends

edited by

Monica Casiraghi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 801 | Submission Open

Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations

edited by

Yoichi Morofuji

submission deadline 31 Jan 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery

(This special issue belongs to the Section Clinical Neurology)

Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment

edited by Pierre Sabouret,

Giuseppe Andò

and

Elad Asher

submission deadline 31 Jan 2026 | 1 articles | Viewed by 581 | Submission Open

Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification

(This special issue belongs to the Section Cardiology)

Diagnosis and Treatment of Aortic Dissection: Experts' Views

edited by Marja K Hedman and Annastiina Husso

submission deadline 31 Jan 2026 | 1 articles | Viewed by 533 | Submission Open

Keywords: aortic diseases; aortic type A dissection; aortic growth rate; aortic length; aortic imaging

(This special issue belongs to the Section Cardiology)

Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments

edited by

Niccola Funel

, Paolo Domenico Parchi and Andrea del Chiaro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 500 | Submission Open

Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis; osteoarthritis; musculoskeletal disorder; pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches

(This special issue belongs to the Section Orthopedics)

Application of Artificial Intelligence in Gastric Cancer

edited by

Lorena Torroni

and

Maria Bencivenga

submission deadline 31 Jan 2026 | Viewed by 136 | Submission Open

Keywords: artificial intelligence (AI); gastric cancer; AI-assisted endoscopy; radiomics; robotic surgery; gastrointestinal diseases; digital pathology; translational research; innovation in healthcare

(This special issue belongs to the Section Oncology)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management

edited by István Szokodi and

Attila Kónyi

submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open

Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders

(This special issue belongs to the Section Cardiology)

Clinical Challenges and Advances in Periodontology and Oral Surgery: 2nd Edition

edited by

Glauco Chisci

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: oral surgery; third molar; periodontitis; antibiotics; infection; pain; research; advances; complications; dental implants; bone regeneration; maxillofacial surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Innovations in Spine Care: Advancing Clinical Solutions and Emerging Technologies

edited by

Luca Ambrosio

Fabrizio Russo

, Gianluca Vadalà and Vincenzo Denaro

submission deadline 31 Jan 2026 | Viewed by 99 | Submission Open

Keywords: artificial intelligence; AI; minimally invasive spine surgery; MIS; endoscopic spine surgery; intervertebral disc regeneration; precision medicine; spine care; spine fusion; osteobiologics

(This special issue belongs to the Section Orthopedics)

Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases

edited by

Makoto Hibino

submission deadline 31 Jan 2026 | Viewed by 93 | Submission Open

Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures

(This special issue belongs to the Section Cardiovascular Medicine)

Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

edited by

Konstantinos Stathogiannis

submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open

Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Management of Ligaments and Tendons Injuries

edited by Vivek Kumar Morya

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: tendinopathy; ligaments; tendons; anterior cruciate ligament (ACL); rotator cuff

(This special issue belongs to the Section Orthopedics)

Cardiothoracic and Vascular Anesthesia—Clinical Management and Challenges

edited by Marko Zdravković and

Vlatka Sotosek

submission deadline 31 Jan 2026 | Viewed by 68 | Submission Open

Keywords: cardiac anesthesia; thoracic anesthesia; vascular anesthesia; innovation; perioperative medicine; healthcare; outcomes; challenges

(This special issue belongs to the Section Anesthesiology)

Anesthesia and Pain Management for Women: 2nd Edition

edited by Gaetano Draisci and Stefano Catarci

submission deadline 31 Jan 2026 | Viewed by 65 | Submission Open

Keywords: anesthesia; women; gender differences; acute pain; chronic pain; hormonitoring; pain perception; fibromyalgia; migraine; monitoring; obstetrics; cesarean section; gynecologic surgery

(This special issue belongs to the Section Anesthesiology)

Strategies to Optimize Efficiency of Clear Aligners and Fixed Appliances in the Digital Orthodontics Era

edited by

Maciej Jedliński

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: clear aligners; fixed orthodontic appliances; digital orthodontics; orthodontic treatment planning; tooth movement efficiency; patient-centered care; treatment modality selection

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Skin Cancer: From Diagnosis to Personalized Treatment

edited by

Anthony J. Dixon

submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open

Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery

(This special issue belongs to the Section Dermatology)

Update on Acute Severe Respiratory Infections: 2nd Edition

edited by

Jean-Francois Timsit

submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open

Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition

edited by Senthil Sambandam

submission deadline 31 Jan 2026 | Viewed by 51 | Submission Open

Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening

(This special issue belongs to the Section Orthopedics)

Clinical Updates on Dyslipidemia

edited by

Nathan Wong

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: dyslipidemia; cardiovascular disease; prevention; treatment; risk factors

(This special issue belongs to the Section Cardiovascular Medicine)

Trauma Surgery: Strategies, Challenges and Vision of the Future

edited by Shai Factor and Yaniv S. Warschawski

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: orthopaedic surgery; fractures; injuries; upper limb; trauma

(This special issue belongs to the Section Clinical Research Methods)

Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine

edited by

Cíntia França

and

Élvio Gouveia

submission deadline 3 Feb 2026 | Viewed by 150 | Submission Open

Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery

(This special issue belongs to the Section Sports Medicine)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a Global but Not Liver-Limited Health Challenge—from Disease Pathogenesis to Therapeutic Targets

edited by Beata Kasztelan-Szczerbinska and Halina Cichoż-Lach

submission deadline 5 Feb 2026 | 3 articles | Viewed by 4564 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); non-alcoholic fatty liver disease (NAFLD); hepatic steatosis; multiorgan metabolic interactions; liver-related morbidity; liver-related mortality; lipid metabolism; cardiovascular metabolic complications; metabolic dysfunction-related cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Cardiothoracic Surgery

edited by Hee-Jung Kim and

Seung-Hyun Lee

submission deadline 5 Feb 2026 | Viewed by 62 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence

(This special issue belongs to the Section General Surgery)

Physical Therapy in Neurorehabilitation: Innovations, Challenges and Opportunities

edited by

Daphne Bakalidou

Maria Gabriella Ceravolo

and

Pinelopi Vlotinou

submission deadline 6 Feb 2026 | Viewed by 44 | Submission Open

Keywords: neurorehabilitation; physical activity; neurocognitive rehabilitation; neurogenic bladder; fatigue; sexual dysfunction; accessibility

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates and Perspectives of Implant Dentistry

edited by

Renzo Guarnieri

and

Rodolfo Reda

submission deadline 10 Feb 2026 | 1 articles | Viewed by 5649 | Submission Open

Keywords: osseointegration; soft tissue integration; peri-implant diseases

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Challenges and Advancements in Lateral Skull Base Surgery

edited by Alessia Rubini

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1093 | Submission Open

Keywords: lateral skull base; neurotology; jugular foramen; cerebellopontine angle; petrous apex; inner ear; acoustic neuroma; jugular paraganglioma; transtemporal approaches; infratemporal approaches

(This special issue belongs to the Section Otolaryngology)

Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective

edited by

Roberto Cuomo

and

Ishith Seth

submission deadline 10 Feb 2026 | 1 articles | Viewed by 622 | Submission Open

Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Application of Anticoagulation and Antiplatelet Therapy

edited by

Rossella Marcucci

and

Martina Berteotti

submission deadline 10 Feb 2026 | 1 articles | Viewed by 508 | Submission Open

Keywords: antiplatelets; anticoagulants; atherothrombosis; coronary artery disease; peripheral artery disease; cerebral artery disease; vitamin K antagonists; direct oral anticoagulants; clopidogrel; aspirin; ticagrelor; prasugrel

(This special issue belongs to the Section Cardiovascular Medicine)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 10 Feb 2026 | Viewed by 217 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence

edited by

Massimiliano Creta

submission deadline 10 Feb 2026 | Viewed by 141 | Submission Open

Keywords: extracorporeal shock wave lithotripsy; lasers; percutaneous lithotripsy; robotic surgery; ureteroscopy; urolithiasis

(This special issue belongs to the Section Nephrology & Urology)

Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition

edited by

George K. Psillas

submission deadline 10 Feb 2026 | Viewed by 79 | Submission Open

Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in Pediatric Critical Care Medicine

edited by

Lama Elbahlawan

submission deadline 10 Feb 2026 | Viewed by 76 | Submission Open

Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction

(This special issue belongs to the Section Clinical Pediatrics)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | Viewed by 73 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section Infectious Diseases)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Feb 2026 | Viewed by 72 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools

(This special issue belongs to the Section Mental Health)

Management of Congenital Heart Disease (CHD)

edited by Sarah Nordmeyer and Marie Schafstedde

submission deadline 10 Feb 2026 | Viewed by 66 | Submission Open

Keywords: congenital heart disease; imaging; diagnostics; surgical innovations; minimally invasive interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Concepts in Ovarian Cancer: Epidemiology, Diagnosis, Treatment and Quality of Life

edited by Giulia Scotto and

Giorgio Valabrega

submission deadline 10 Feb 2026 | Viewed by 66 | Submission Open

Keywords: ovarian cancer; quality of life; multidisciplinary care; personalized medicine; PARP inhibitors

(This special issue belongs to the Section Oncology)

Clinical Advances in Spine Disorders—2nd Edition

edited by

Sokol Trungu

and

Luca Ricciardi

submission deadline 10 Feb 2026 | Viewed by 65 | Submission Open

Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Pain Management

edited by Jamal Hasoon and Omar Viswanath

submission deadline 13 Feb 2026 | 5 articles | Viewed by 6546 | Submission Open

Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures

(This special issue belongs to the Section Anesthesiology)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 15 Feb 2026 | 4 articles | Viewed by 2441 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

edited by Cristian George Ţieranu and

Adrian Saftoiu

submission deadline 15 Feb 2026 | Viewed by 2068 | Submission Open

Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiac Electrophysiology: Focus on Clinical Practice

edited by

Andreas Müssigbrodt

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1409 | Submission Open

Keywords: cardiomyopathy; arrhythmia; heart rhythm; atrial fibrillation; ventricular tachycardia; sudden cardiac death; mapping; ablation; pulsed field ablation (PFA); device; pacemaker; left bundle branch area pacing (LBBAP); conduction system pacing (CSP); implantable cardioverter-defibrillator (ICD); leadless pacing; extraction

(This special issue belongs to the Section Cardiology)

Displaying special issue 1001-1050 on page 21 of 30.

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