From Hyperfunction to Insufficiency: A Comprehensive Look at Adrenal Disorders
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 39
Special Issue Editors
Interests: cardiovascular risk and endocrine hypertension; adrenal disorders; hydroelectrolyte disroders; primary aldosteronism; clinical endocrinology
Special Issue Information
Dear Colleagues,
Functional adrenal disorders comprise a heterogeneous group of conditions, ranging from hormone excess (such as Cushing’s syndrome and primary aldosteronism) to adrenal insufficiency. These conditions often present with nonspecific symptoms, and many cases remain undiagnosed or are misdiagnosed for years. Advances in biochemical testing, imaging, and genetics have improved detection and understanding, yet major challenges remain in diagnosis, risk stratification, and long-term management.
The burden of adrenal disorders is significant, affecting cardiovascular, metabolic, and bone health and often requiring lifelong treatment. Subclinical forms, such as mild autonomous cortisol or aldosterone secretion, are increasingly recognized, but their natural history and optimal management are still debated. On the other end of the spectrum, adrenal insufficiency continues to carry risks of under-replacement and adrenal crisis, despite established therapies, while hypoaldosteronism remains underdetected and its clinical implications largely unexplored.
This Special Issue will explore the full clinical and pathophysiological spectrum of adrenal disorders through original research and review articles, aiming to address current gaps and improve patient care.
Dr. Jorge Gabriel Ruiz-Sánchez
Dr. Patricia Y. Fechner
Guest Editors
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Keywords
- primary aldosteronism
- hypoaldosteronism
- hypercortisolism
- adrenal insufficiency
- autonomous cortisol secretion
- cushing syndrome
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