Osteosarcoma: New Insights into Diagnosis and Treatment
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 21
Special Issue Editor
Special Issue Information
Dear Colleagues,
For the last three decades, therapies and outcomes for patients with osteosarcoma have remained largely unchanged. However, recent advances in understanding tumor biology coupled with the availability of novel therapies and methods for improved prognostication and response assessment are reshaping our approach to this disease. The goal of this Special Issue is to provide clinicians with an update on (1) the most current therapy options, including tyrosine kinase inhibitors and immunotherapy, (2) new strategies for clinical trial design, (3) controversies and new advances in surgical resection of lung metastases, (4) genetic characterization of tumors and its potential therapeutic impact, (5) use of liquid biopsies and deep learning for prognosis and response assessment, and (6) how preclinical discoveries regarding intratumoral heterogeneity, treatment resistance, and development of metastases can be translated to the clinic. With input from established leaders in each area, we hope this broad array of timely topics will inform treating physicians and inspire further discovery that can lead to improved outcomes for children, adolescents, and young adults with osteosarcoma.
Prof. Dr. Lars M. Wagner
Guest Editor
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Keywords
- osteosarcoma
- tyrosine kinase inhibitors
- immunotherapy
- clinical trial design
- intratumoral heterogeneity
- liquid biopsy
- metastasectomy
- deep learning
- translational research
- targeted therapy
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