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Intracranial Aneurysms: Diagnostics and Current Treatment
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Intracranial Aneurysms: Diagnostics and Current Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 533

Special Issue Editors

Dr. Vincenzo Antonelli

E-Mail Website
Guest Editor
Department of Neurosurgery, Hospital M. Bufalini—AUSL della Romagna, Cesena, Italy
Interests: neurosurgery; vascular suregry; brain injury; neuroncology, cranial base
Dr. Roberto Colasanti

E-Mail Website
Guest Editor
Department of Neurosurgery, Hospital M. Bufalini—AUSL della Romagna, Cesena, Italy
Interests: neurosurgery; vascular suregry; brain Injury; neuroncology; cranial base
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurovascular diseases remain one of the leading causes of global morbidity and mortality, thus representing a major public health threat. In the last few decades, various advancements have progressively improved the diagnosis of intracranial aneurysms, as well as their clinical and surgical management. In addition, advancements in artificial intelligence and related technologies could optimize early and precise detection methodologies and enhance treatment algorithms. However, challenges still remain.

The aim of this Special Issue is to highlight the current research and progress for every aspect of the management of intracranial aneurysms (primary and secondary prevention, when possible, diagnostic imaging, acute inpatient care, endovascular and/or surgical treatment, complication management, rehabilitation and recovery, as well as progress in translational science). Our goal is to provide a detailed overview of key discoveries, novel diagnostic and innovative treatment methods and improved application of established approaches, while shedding light on emerging research areas and future perspectives.

We eagerly anticipate contributions on ruptured and un-ruptured aneurysms (e.g., diagnosis, treatment algorithms, current endovascular and surgical management, intensive care, clinical prevention and treatment of vasospasm and other potential complications, postoperative rehabilitation, etc.). In addition, we encourage interdisciplinary collaborations, inviting contributions from neurosurgeons, neuroradiologists, neurologists, neurorehabilitation specialists, and other allied healthcare professionals.

Dr. Vincenzo Antonelli
Dr. Roberto Colasanti
Guest Editors

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Keywords

  • neurovascular diseases
  • aneurysms
  • vascular malformations
  • diagnostic imaging
  • minimally invasive approaches
  • surgical techniques
  • endovascular interventions
  • treatment algorithms
  • subarachnoid hemorrhage
  • neurorehabiltation

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Published Papers (1 paper)

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16 pages, 4980 KiB  
Case Report
Complex Anatomy, Advanced Techniques: Microsurgical Clipping of a Ruptured Hypophyseal Artery Aneurysm
by Corneliu Toader, Matei Serban, Nicolaie Dobrin, Razvan-Adrian Covache-Busuioc, Mugurel Petrinel Radoi, Alexandru Vlad Ciurea and Octavian Munteanu
J. Clin. Med. 2025, 14(7), 2361; https://doi.org/10.3390/jcm14072361 - 29 Mar 2025
Viewed by 365
Abstract
Background: Ruptured intracranial aneurysms remain the subject of debate in their management, but the management of lesions located at high-risk locations, such as the hypophyseal artery, continue to prove to be a challenge in anatomical orientation and proximity to vascular structures. While endovascular [...] Read more.
Background: Ruptured intracranial aneurysms remain the subject of debate in their management, but the management of lesions located at high-risk locations, such as the hypophyseal artery, continue to prove to be a challenge in anatomical orientation and proximity to vascular structures. While endovascular therapies have changed the treatment paradigms, microsurgical clipping is the gold standard for wide-necked aneurysms for which endovascular techniques may be suboptimal. The successful treatment of a ruptured hypophyseal artery aneurysm in an elderly patient is described in this report, which highlights the importance of advanced imaging, careful technique, and new understanding of personalized aneurysm management. Methods: An 82-year-old woman was admitted with a thunderclap headache, alteration of consciousness and meningeal signs, suggestive of subarachnoid hemorrhage (SAH). A non-contrast computed tomography (CT) and digital subtraction angiography (DSA) confirmed a saccular 12 × 10 mm aneurysm with a broad 3.13 mm neck arising from the hypophyseal artery. The location and morphology of the aneurysm required microsurgical clipping, which was performed through a right pterional craniotomy. Results: Correct clip placement, complete exclusion of the aneurysm, and resorption of the subarachnoid blood were both observed on postoperative imaging. The neurological examination was completely normal, with no complications. Follow-up imaging at three months demonstrated stable, marked cerebral atrophy with compensatory ventricular enlargement without evidence of recurrence. Conclusions: This case illustrates the important role of micro-surgical clipping in anatomically complex aneurysms and its sustainable outcome and accuracy in cases where endovascular practices would have limitations. Advanced imaging, like three-dimensional DSA and intraoperative tools, have revolutionized precision surgery, allowing achievement of optimal outcomes, even for more-complicated cases. With an evolving, dynamic field and exciting new technologies coming to the fore—such as artificial intelligence to predict rupture risk and augmented reality navigation—decision-making and treatment of complex aneurysms will be optimized along secure pathways towards tailored, high-resolution treatment in the sense of personalized and yet high-precision care. Full article
(This article belongs to the Special Issue Intracranial Aneurysms: Diagnostics and Current Treatment)
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