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Degenerative Cervical Myelopathy and Traumatic Spinal Cord Injury: Recent Advances and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 28 March 2026 | Viewed by 13

Special Issue Editors


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Guest Editor
Department of Neurosurgery and Spine Center, HOCH health Ostschweiz, Cantonal Hospital of St. Gallen, 9000 St. Gallen, Switzerland
Interests: traumatic spinal cord Injury; degenerative cervical myelopathy (DCM); cervical spine surgery; degenerative lumbar spine disease; tumors

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Guest Editor
Division of Neurosurgery and Spine Program, Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada
Interests: traumatic spinal cord injury; degenerative cervical myelopathy (DCM); cervical spine surgery; clinical trials; stem cells; spine tumors

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Guest Editor
Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland
Interests: structural and functional MRI; brain and spinal cord imaging; degenerative cervical myelopathy (DCM); spinal cord injury (SCI)

Special Issue Information

Dear Colleagues,

Degenerative cervical myelopathy (DCM) and traumatic spinal cord injury (SCI) are among the most significant spinal cord disorders, affecting millions worldwide and causing substantial physical, social, and economic burdens. While differing in etiology and demographics, these conditions share key pathophysiological characteristics. Over the past decades, advances in clinical assessment, imaging, non-surgical and surgical interventions, and rehabilitation have significantly improved patient care. Despite the development of clinical practice guidelines by leading spine organizations, many uncertainties persist, underscoring the need for continued research. Although numerous neuroprotective and neuroregenerative trials have been conducted, their overall efficacy has remained limited. However, the coming years promise a paradigm shift in DCM and SCI management, driven by high-quality evidence, combinatorial therapies, and a personalized medicine approach. This Special Issue of the Journal of Clinical Medicine highlights recent advances in managing these conditions, identifies key knowledge gaps, including outcome prediction, and explores potential therapeutic targets for future breakthroughs.

Dr. Nader Hejrati
Dr. Michael G. Fehlings
Dr. Maryam Seif
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • degenerative cervical myelopathy
  • traumatic spinal cord injury
  • clinical assessment
  • surgical management
  • non-operative management
  • neuroprotective therapies
  • neuroregenerative therapies
  • outcome prediction

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Published Papers

This special issue is now open for submission.
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