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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition

edited by

Jose Alberto De Agustín

submission deadline 20 Apr 2026 | Viewed by 171 | Submission Open

Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques

edited by Argyrios Tzamalis

submission deadline 20 Apr 2026 | Viewed by 162 | Submission Open

Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided

Clinical Advances in Musculoskeletal Pain

edited by

Dariusz Kosson

Barbara Lisowska

and

Paweł Łęgosz

submission deadline 20 Apr 2026 | Viewed by 123 | Submission Open

Keywords: musculoskeletal pain; chronic pain; primary musculoskeletal pain; secondary chronic musculoskeletal pain; multi-disciplinary pain treatment; imaging in interventional pain management

(This special issue belongs to the Section Orthopedics)

Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes

edited by Athanassios A. Kyrgidis and

Aimilios Lallas

submission deadline 20 Apr 2026 | Viewed by 119 | Submission Open

Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life

(This special issue belongs to the Section Dermatology)

Clinical Management for Anesthesia Critical Care

edited by Gianluca Zani

submission deadline 20 Apr 2026 | Viewed by 112 | Submission Open

Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills

(This special issue belongs to the Section Anesthesiology)

The Latest Research on Male Infertility

edited by Gianmaria Salvio and Nicola delli Muti

submission deadline 20 Apr 2026 | Viewed by 109 | Submission Open

Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Advances in Minimally Invasive Spinal Treatment: 2nd Edition

edited by

Akihiko Hiyama

Haruki Funao

and

Masayuki Ishihara

submission deadline 20 Apr 2026 | Viewed by 102 | Submission Open

Keywords: robotic-assisted spine surgery; artificial intelligence (AI); machine learning (ML); cement-augmented pedicle screws; cement leakage risk stratification; osteoporosis pharmacotherapy; surgical navigation systems; image-guided spine surgery; predictive analytics in spine care; spine technology innovation

(This special issue belongs to the Section Orthopedics)

Heart Failure: Treatment and Clinical Perspectives

edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni

submission deadline 20 Apr 2026 | Viewed by 100 | Submission Open

Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis

(This special issue belongs to the Section Cardiology)

Hip and Knee Arthroplasty: Update on Clinical Management

edited by Maximilian F. Kasparek

submission deadline 20 Apr 2026 | Viewed by 99 | Submission Open

Keywords: total hip arthroplasty (THA); total knee arthroplasty (TKA); revision arthroplasty; implant fixation; cemented; cementless; hybrid; alignment in TKA; mechanical alignment; kinematic alignment; restricted kinematic alignment; functional alignment; navigation; robotic-assisted surgery; patient-specific instrumentation; additive manufacturing; 3D printing; personalized implant

(This special issue belongs to the Section Orthopedics)

Advances and Challenges in Head and Neck Reconstructive Surgery

edited by

Valeria Navach

Olindo Massarelli

and Luca Calabrese

submission deadline 20 Apr 2026 | Viewed by 97 | Submission Open

Keywords: reconstructive surgery; head and neck; innovation; microsurgery; virtual surgical planning; 3D-printed implants; tissue engineering

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Myocardial Infarction: The Latest Advances and Prospects

edited by

Stylianos Daios

and Antonios Ziakas

submission deadline 20 Apr 2026 | Viewed by 95 | Submission Open

Keywords: coronary artery disease; myocardial infarction; PPCI; echocardiography; antiplatelet agents; radial access; global longitudinal strain

(This special issue belongs to the Section Cardiology)

Innate Immunity in Overdrive: Novel Insights into Autoinflammatory Syndromes

edited by Alessandro Conforti

submission deadline 20 Apr 2026 | Viewed by 94 | Submission Open

Keywords: autoinflammatory diseases; innate immunity; inflammasome; cytokines; Interleukin-1; monogenic syndromes; polygenic autoinflammatory disorders; adult-onset Still’ s disease; Behç et’ s disease; targeted therapy; disease registries; real-world evidence; VEXAS syndrome; UBA1 mutations; precision medicine; biomarkers; outcome assessment

(This special issue belongs to the Section Immunology & Rheumatology)

New Insights into Retinal Diseases

edited by Fabio Scarinci and Giulio Pocobelli

submission deadline 20 Apr 2026 | Viewed by 94 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow

(This special issue belongs to the Section Ophthalmology)

Pharmacotherapy of Mental Diseases: Latest Developments

edited by

Lavinia Maria Hogea

and

Laura Alexandra Nussbaum

submission deadline 20 Apr 2026 | Viewed by 92 | Submission Open

Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases

(This special issue belongs to the Section Mental Health)

New Insights in Joint Arthroplasty—2nd Edition

edited by

Richard Lass

submission deadline 20 Apr 2026 | Viewed by 91 | Submission Open

Keywords: total hip arthroplasty; total knee arthroplasty; robotic-assisted technology and navigation; modern implant materials; modern implant fixation techniques; alignment in TKA; spinopelvic alignment in THA

(This special issue belongs to the Section Orthopedics)

Advances in the Management of Pediatric Neuromuscular Diseases

edited by Nicolas Deconinck

submission deadline 20 Apr 2026 | Viewed by 91 | Submission Open

Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines

(This special issue belongs to the Section Clinical Neurology)

Vertebral Fractures and Spinal Cord Injury: Advances in Management

edited by

Marc Dreimann

and Martin Stangenberg

submission deadline 20 Apr 2026 | Viewed by 90 | Submission Open

Keywords: fracture management; spinal cord injuries; artificial intelligence; machine learning; spinal trauma

(This special issue belongs to the Section Orthopedics)

Schizophrenia and Psychotic Disorders: Clinical Updates

edited by Octavian Vasiliu and

Adela Magdalena Ciobanu

submission deadline 20 Apr 2026 | Viewed by 89 | Submission Open

Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities

(This special issue belongs to the Section Mental Health)

Recent Management and Future Perspectives on Knee Arthroplasty

edited by

Georgios Komnos

submission deadline 20 Apr 2026 | Viewed by 88 | Submission Open

Keywords: knee arthroplasty; individualized approach; implant designs; robotic-assisted; knee alignment

(This special issue belongs to the Section Orthopedics)

Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis

edited by Francescamaria Donati

submission deadline 20 Apr 2026 | Viewed by 87 | Submission Open

Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly

edited by

Oded Hershkovich

and

Raphael Lotan

submission deadline 20 Apr 2026 | Viewed by 81 | Submission Open

Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty

(This special issue belongs to the Section Orthopedics)

Coronary Artery Disease: Recent Developments and Emerging Trends

edited by

Attila Kardos

and Tarun Mittal

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: coronary atherosclerosis; diagnostic strategies; therapeutic options; timing of intervention; artificial intelligence; novel therapeutic pathways

(This special issue belongs to the Section Cardiology)

Peritoneal Dialysis and Hemodialysis: Early and Late Outcomes

edited by Keren Cohen-Hagai and

David Pereg

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: peritoneal dialysis; dialysis; hemodialysis; chronic kidney disease; end-stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Novel Advances in Lower Limb Trauma and Orthopaedic Surgery

edited by Konstantinos Tsikopoulos and

Panagiotis Givissis

submission deadline 20 Apr 2026 | Viewed by 79 | Submission Open

Keywords: lower limb orthopedic surgery; trauma; infection; research

(This special issue belongs to the Section Orthopedics)

Geriatric Fracture Care: Bridging Orthopedics and Gerontology

edited by Tom Knauf and Daphne Asimenia Eschbach

submission deadline 20 Apr 2026 | Viewed by 78 | Submission Open

Keywords: geriatric fracture; proximal femur fractures; hip fracture; geriatric trauma patient; ortho-geriatric treatment; periprosthetic fracture; end of life decision; orthopedic surgery in the elderly

(This special issue belongs to the Section Geriatric Medicine)

Advancements in Minimally Invasive Neurosurgery

edited by Sanjeeva Jeyaretna and Kumar Abhinav

submission deadline 20 Apr 2026 | Viewed by 78 | Submission Open

Keywords: minimally invasive surgery; skull base surgery; neurosurgery; transorbital; endoscopic transnasal

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Endodontic Dentistry

edited by

Luciano Giardino

and

Luigi Generali

submission deadline 20 Apr 2026 | Viewed by 73 | Submission Open

Keywords: antimicrobial agents; biofilm; confocal laser scanning microscopy; endodontic materials; irrigants; microbiome; micro-CT; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Female Infertility: Clinical Diagnosis and Treatment—Second Edition

edited by

Laurie Henry

submission deadline 20 Apr 2026 | Viewed by 72 | Submission Open

Keywords: infertility; assisted reproductive techniques; diagnosis; implantation; gametes

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Risk Minimization Through Robot-Assisted Surgery

edited by Radko Komadina

submission deadline 20 Apr 2026 | Viewed by 71 | Submission Open

Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy

(This special issue belongs to the Section General Surgery)

New Advances in Orthopedic Knee Joint Preserving and Reconstructive Surgery

edited by

Dong Jin Ryu

and

Sung-Sahn Lee

submission deadline 20 Apr 2026 | Viewed by 68 | Submission Open

Keywords: cartilage regeneration; patient-specific instrumentation; knee robotic surgery; patient-specific surgical device; future orthopedics

(This special issue belongs to the Section Orthopedics)

Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 63 | Submission Open

Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing

(This special issue belongs to the Section Cardiology)

New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team

edited by

Marco Materazzo

and

Antonia Girardi

submission deadline 20 Apr 2026 | Viewed by 63 | Submission Open

Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment

(This special issue belongs to the Section Oncology)

New Sights in Retinal Diseases Therapeutics: Innovation and Clinical Practice

edited by

Giacomo Boscia

Pasquale Viggiano

, Stefano Dore and Alfonso Savastano

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: retinal diseases; central serous chorioretinopathy; age-related macular degeneration; eye diseases; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition

edited by Adriaan A. Lammertsma

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Research on Pulmonary Hypertension and Its Complications

edited by Gabor G. Kovacs and

Anna Birnhuber

submission deadline 20 Apr 2026 | Viewed by 59 | Submission Open

Keywords: pulmonary hypertension; PH; pulmonary arterial pressure; different diagnostic; therapeutic challenges

(This special issue belongs to the Section Respiratory Medicine)

Clinical Cardiac Rehabilitation: Integrating Multidimensional Approaches for Enhanced Cardiovascular Health

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 57 | Submission Open

Keywords: cardiac rehabilitation; multidimensional approach; integrating approach; cardiovascular health; primary and secondary prevention

(This special issue belongs to the Section Clinical Rehabilitation)

Innovations in Surgical and Medical Approaches of Urologic Oncology

edited by

Sung Han Kim

submission deadline 20 Apr 2026 | Viewed by 55 | Submission Open

Keywords: urologic oncology; robotic surgery; immunotherapy; targeted therapy; image-guided techniques; personalized medicine; minimally invasive surgery; focal therapy

(This special issue belongs to the Section Nephrology & Urology)

New Challenges and Perspectives in Surgical Treatment of Spinal Deformity

edited by Jung-Hee Lee

submission deadline 20 Apr 2026 | Viewed by 51 | Submission Open

Keywords: adult spinal deformity; decompensation; kyphosis; lateral lumbar interbody fusion; orthopedic surgery; osteotomy; proximal junctional kyphosis; rod fracture

(This special issue belongs to the Section Orthopedics)

Spinal Cord Injury in Elderly People: Prevention of Complications

edited by Vaidyanathan Subramanian

submission deadline 20 Apr 2026 | Viewed by 50 | Submission Open

Keywords: spinal cord injury; demography; morbidities; complications; spinal injuries; patients; family members; caregivers; general practitioners; discharge; elderly

(This special issue belongs to the Section Geriatric Medicine)

Aiming for Early Detection and Prevention of Pulmonary Diseases

edited by

Nektarios Anagnostopoulos

and

Kostas A. Papavassiliou

submission deadline 20 Apr 2026 | Viewed by 40 | Submission Open

Keywords: early diagnosis; prevention strategies; respiratory diseases; artificial intelligence; asthma; chronic obstructive pulmonary disease (COPD); interstitial lung disease; sleep-disordered breathing

(This special issue belongs to the Section Respiratory Medicine)

What Part Do Circulating Tumor Cells Play in Cancers？

edited by

Monika Pizon

and

Katharina Pachmann

submission deadline 20 Apr 2026 | Viewed by 23 | Submission Open

Keywords: circulating tumor cells (CTCs); circulating cancer stem cells (cCSCs); liquid biopsy; therapy monitoring; metastasis; cancer progression

(This special issue belongs to the Section Oncology)

Genitourinary Tumors and Radiation Therapy: Current Advances and Future Directions

edited by Shalini Moningi

submission deadline 20 Apr 2026 | Viewed by 16 | Submission Open

Keywords: cancer; prostate cancer; bladder cancer; kidney cancer; radiation therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Management of Knee Arthroplasty

edited by

Sang-Hoon Park

submission deadline 21 Apr 2026 | 1 articles | Viewed by 699 | Submission Open

Keywords: knee surgery; knee arthroplasty; knee joint replacement; osteoarthritis; knee arthritis

(This special issue belongs to the Section Orthopedics)

Controversies in Hidradenitis Suppurativa: Bridging Gaps in Science and Practice

edited by Hadar Lev-Tov and Tammy González

submission deadline 21 Apr 2026 | Viewed by 98 | Submission Open

Keywords: hidradenitis suppurativa (HS); inflammatory skin disorder; controversies; treatment strategies; science and practice

(This special issue belongs to the Section Dermatology)

Paediatric Anaesthesia: Clinical Updates and Perspectives

edited by Peter Marhofer, Philipp Opfermann and Markus Zadrazil

submission deadline 24 Apr 2026 | 7 articles | Viewed by 8574 | Submission Open

Keywords: pediatric anesthesia; anesthesia; conduction; ultrasonography; conscious sedation; deep sedation; drug-related side effects and adverse reactions; neurotoxicity syndromes

(This special issue belongs to the Section Anesthesiology)

Challenges and Advances in Geriatrics and Gerontology

edited by Elisa Fabbri

submission deadline 24 Apr 2026 | 3 articles | Viewed by 1782 | Submission Open

Keywords: aging; geriatric medicine; frailty; multimorbidity; sarcopenia; cognition; personalized-care; healthy longevity; decision making-management; prevention; artificial intelligence

(This special issue belongs to the Section Geriatric Medicine)

Advances in Spine Surgery: Current Innovations and Future Directions

edited by

Gonzalo Mariscal

and Jesús Burgos

submission deadline 24 Apr 2026 | Viewed by 120 | Submission Open

Keywords: spine; clinical studies; robotics; minimally invasive; complications; patient-reported outcomes; reviews

(This special issue belongs to the Section Orthopedics)

Innovations and Challenges in Clinical Toxicology and Therapeutic Drug Monitoring

edited by Zhicheng Jin

submission deadline 25 Apr 2026 | 2 articles | Viewed by 19514 | Submission Open

Keywords: toxicology screen; therapeutic drug monitoring; mass spectrometry; immunoassays; pain management; opioids

(This special issue belongs to the Section Pharmacology)

General Anesthesia: Recent Developments and Emerging Trends

edited by Basavana Goudra

submission deadline 25 Apr 2026 | 3 articles | Viewed by 15489 | Submission Open

Keywords: general anesthesia; recent advances; drug development; memory and awareness; brain monitoring; sugammadex; tegileridine

(This special issue belongs to the Section Anesthesiology)

Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition

edited by

Antonella Polimeni

and

Iole Vozza

submission deadline 25 Apr 2026 | 7 articles | Viewed by 13575 | Submission Open

Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 1151-1200 on page 24 of 31.

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