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Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 147

Special Issue Editors


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Guest Editor
Department of Oral and Maxillofacial Surgery, School of Dentistry, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece
Interests: skin cancer; head and neck cancer; melanoma; clinical pharmacology; patient-reported outcome measures; clinical biomarkers; prognostic factors; epidemiology; oral and maxillofacial surgery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
Interests: skin cancer; melanoma; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; dermatoscopy; artificial intelligence; immunotherapy; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin cancer incidence is increasing. Different forms of skin cancer include melanoma, basal cell carcinoma, and squamous cell carcinoma, each with varying degrees of severity and treatment requirements. The economic impact of skin cancer is substantial, as it involves not only the direct expenses associated with diagnosis and treatment, but also the long-term management of survivors and the prevention efforts required to reduce its incidence. Consequently, healthcare systems require considerable financial resources, specialized personnel, and infrastructure to meet the growing demand for skin cancer care and mitigate its profound impact on patients and society as a whole. Skin cancer can significantly impact the quality of life of individuals, as it may lead to physical discomfort, disfigurement, emotional distress, and limitations in daily activities due to the disease itself or the necessary treatments. The treatment outcomes are important as new treatments emerge that need to be administered to patients on the grounds of sufficient evidence. Quality of life (QoL) outcome research in dermatology focuses on understanding how skin conditions impact a patient's overall well-being, including physical and psychological. This research utilizes patient-reported outcome measures (PROMs), such as questionnaires, to assess the effects of dermatological conditions and their treatments. Accordingly, a Special Issue called “Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes” is announced. This Special Issue calls for original research and systematic reviews that investigate clinical, dermoscopic, diagnostic, or therapeutic features of skin cancers and their impact on patients’ outcomes.

Dr. Athanassios A. Kyrgidis
Prof. Dr. Aimilios Lallas
Guest Editors

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Keywords

  • skin cancer
  • melanoma
  • squamous cell carcinoma
  • basal cell carcinoma
  • clinical biomarkers
  • dermoscopy
  • quality of life

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Published Papers (1 paper)

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9 pages, 1537 KB  
Case Report
Verrucous Carcinoma of the Lower Lip: A Rare Case Mimicking Benign Lesion
by Dong Gyu Kim and Kyung Ah Lee
J. Clin. Med. 2025, 14(24), 8763; https://doi.org/10.3390/jcm14248763 - 11 Dec 2025
Abstract
Background: Verrucous carcinoma (VC) is a rare, well-differentiated subtype of squamous cell carcinoma characterized by slow growth and local invasiveness. Although it can arise in various anatomical regions, involvement of the lip is uncommon. Because VC may clinically resemble benign verrucous lesions such [...] Read more.
Background: Verrucous carcinoma (VC) is a rare, well-differentiated subtype of squamous cell carcinoma characterized by slow growth and local invasiveness. Although it can arise in various anatomical regions, involvement of the lip is uncommon. Because VC may clinically resemble benign verrucous lesions such as squamous cell papilloma, accurate diagnosis is often delayed. This case report aims to illustrate the diagnostic pitfalls encountered when lower-lip VC is managed as a benign verrucous lesion and to emphasize the need for adequately deep or excisional biopsy in persistent lesions that fail to respond to conservative treatment. Methods: We report the case of a 75-year-old man who presented with a persistent, cauliflower-like lesion on the lower lip initially diagnosed as verruca. Despite repeated cryotherapy, the lesion enlarged. Wide local excision was performed under general anesthesia, and frozen biopsy suggested malignancy. The resultant defect was reconstructed using a step-ladder advancement flap designed to preserve lip symmetry and function. Results: Histopathologic examination revealed a well-differentiated squamous epithelium with parakeratinized invaginations extending into the stroma, confirming VC. The postoperative course was uneventful, with preserved oral competence and no evidence of recurrence during follow-up. Conclusions: Verrucous carcinoma of the lip can be misdiagnosed as a benign papillomatous or verrucous lesion, particularly when only a superficial biopsy is obtained and management relies on prolonged conservative therapy such as repeated cryotherapy. Persistent verrucous lesions of the lip that do not respond to an apparently adequate course of treatment should prompt reconsideration of the diagnosis and performance of an adequately deep or excisional biopsy. Complete excision with negative margins remains the treatment of choice, and increased clinical awareness, together with careful histopathologic evaluation, are essential for early detection and appropriate management, ultimately improving patient outcomes and minimizing morbidity. Full article
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