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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endocarditis: Clinical Updates on Diagnosis, Treatment and Management
edited by Katarzyna Holcman
submission deadline 25 Mar 2026 | Viewed by 95 | Submission Open
Keywords: infective endocarditis; PET; SPECT; echocardiography; antimicrobial therapy; cardiac surgery; multimodality imaging
(This special issue belongs to the Section Cardiology)
Osteosarcoma: New Insights into Diagnosis and Treatment
edited by Lars M. Wagner
submission deadline 25 Mar 2026 | Viewed by 94 | Submission Open
Keywords: osteosarcoma; tyrosine kinase inhibitors; immunotherapy; clinical trial design; intratumoral heterogeneity; liquid biopsy; metastasectomy; deep learning; translational research; targeted therapy
(This special issue belongs to the Section Oncology)
Advances in Schizophrenia and Related Psychotic Disorders
edited by Giovanni Camardese and Michele Ribolsi
submission deadline 25 Mar 2026 | Viewed by 92 | Submission Open
Keywords: psychosis; schizophrenia; severe mental illness; psychopharmacology; negative symptoms; antipsychotics
(This special issue belongs to the Section Mental Health)
Artificial Intelligence in Acute Care Surgery and Trauma Health Care
edited by and Daniel Stephens
submission deadline 25 Mar 2026 | Viewed by 87 | Submission Open
Keywords: artificial neural networks; robotic surgery; virtual reality; augmented reality; artificial intelligence; virtual reality; deep learning
(This special issue belongs to the Section Emergency Medicine)
Diagnosis and Treatment for Hearing Loss: Expert Views
edited by and John L. Dornhoffer
submission deadline 25 Mar 2026 | Viewed by 81 | Submission Open
Keywords: hearing loss; cochlear implants; hearing aid technology; regenerative medicine; diagnostic audiology
(This special issue belongs to the Section Otolaryngology)
Contemporary Trends in Cardiovascular Prevention
edited by Alessandro Durante and
submission deadline 25 Mar 2026 | Viewed by 81 | Submission Open
Keywords: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia
(This special issue belongs to the Section Cardiovascular Medicine)
Pulmonary Embolism: Bridging Cutting-Edge Research and Clinical Practice
edited by and Vivian Lee Bishay
submission deadline 25 Mar 2026 | Viewed by 77 | Submission Open
Keywords: pulmonary embolism; catheter-directed thrombectomy; catheter-directed thrombolysis; post-pulmonary embolism syndrome; chronic thromboembolic disease; chronic thromboembolic pulmonary hypertension
(This special issue belongs to the Section Respiratory Medicine)
Clinical Management of Vestibular Disorders
edited by and Sun-Young Oh
submission deadline 25 Mar 2026 | Viewed by 75 | Submission Open
Keywords: vestibular disorders; vertigo; dizziness; balance; BPPV; vestibular rehabilitation; telemedicine; multidisciplinary care
(This special issue belongs to the Section Otolaryngology)
From Heart to Brain: Interdisciplinary Perspectives on Cerebral Infarction
edited by and Jean-Claude Deharo
submission deadline 25 Mar 2026 | Viewed by 72 | Submission Open
Keywords: ischemic stroke; cardioembolic stroke; atrial fibrillation; heart– brain axis; neurocardiology; post-stroke cardiac dysfunction; stroke prevention; cerebral infarction; cardiac monitoring in stroke; secondary stroke prevention
(This special issue belongs to the Section Clinical Neurology)
Hematologic Malignancies: Treatment Strategies and Future Challenges: 2nd Edition
edited by Masaaki Noguchi
submission deadline 25 Mar 2026 | Viewed by 61 | Submission Open
Keywords: hematologic malignancies; relapse; refractory; drug resistance; therapeutic strategies; new target; biomarkers; new insights
(This special issue belongs to the Section Hematology)
Dentistry and Oral Surgery: Current Status and Future Prospects submission deadline 26 Mar 2026 | 3 articles | Viewed by 6571 | Submission Open
Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Ocular Surface, Retina, and Choroid as Mirrors of Systemic and Genetic Diseases submission deadline 27 Mar 2026 | 4 articles | Viewed by 9527 | Submission Open
Keywords: ocular surface; retina; choroid; systemic diseases; genetic conditions; biomarkers; diagnostic imaging; neuroretina; infectious diseases
(This special issue belongs to the Section Ophthalmology)
Current Progress in the Treatment of Cornea and Ocular Surface Diseases
edited by Marco Messina and
submission deadline 27 Mar 2026 | 2 articles | Viewed by 2969 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis
(This special issue belongs to the Section Ophthalmology)
Vascular and Endovascular Surgery: Current Progress and Future Challenges
edited by Michael Keese and Martin Sigl
submission deadline 28 Mar 2026 | 5 articles | Viewed by 7155 | Submission Open
Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary
(This special issue belongs to the Section Vascular Medicine)
Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition
edited by and Danielle Elizabeth Greig
submission deadline 28 Mar 2026 | 5 articles | Viewed by 3822 | Submission Open
Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies
(This special issue belongs to the Section Orthopedics)
Degenerative Cervical Myelopathy and Traumatic Spinal Cord Injury: Recent Advances and Future Directions
edited by Nader Hejrati, and Maryam Seif
submission deadline 28 Mar 2026 | 1 articles | Viewed by 1667 | Submission Open
Keywords: degenerative cervical myelopathy; traumatic spinal cord injury; clinical assessment; surgical management; non-operative management; neuroprotective therapies; neuroregenerative therapies; outcome prediction
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Cholecystitis and Complications
edited by Dimitrios Balalis, and Nikolaos Vassos
submission deadline 28 Mar 2026 | 1 articles | Viewed by 763 | Submission Open
Keywords: gallbladder; cholecystitis; right upper quadrant pain; ultrasound; laparoscopic approach
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Novel Research in the Management of Cardiac Arrest
edited by Giovanni Babini and
submission deadline 28 Mar 2026 | Viewed by 743 | Submission Open
Keywords: cardiac arrest; post-cardiac arrest syndrome; resuscitation; temperature control; target temperature management; neuroprotection; neuroprognostication; defibrillation; extracorporeal life support
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition
edited by and
submission deadline 28 Mar 2026 | Viewed by 225 | Submission Open
Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis
(This special issue belongs to the Section Oncology)
Mitral Valve Stenosis or Aortic Valve Stenosis: Progress from Diagnosis to Treatment
edited by Francesco Melillo
submission deadline 28 Mar 2026 | Viewed by 106 | Submission Open
Keywords: aortic stenosis; mitral stenosis; TAVI
(This special issue belongs to the Section Cardiology)
Management of Female Pelvic Floor Disorders and Incontinence
edited by Luis López Fando
submission deadline 28 Mar 2026 | Viewed by 105 | Submission Open
Keywords: pelvic floor disorders; urinary incontinence; pelvic organ prolapse; reconstructive urology; voiding dysfunction; multidisciplinary care; surgical techniques; urodynamics; patient-centered outcomes; digital learning in urology
(This special issue belongs to the Section Nephrology & Urology)
Challenges in Minimally Invasive Colorectal and Abdominal Wall Surgery
edited by Francesco Ferrara and
submission deadline 31 Mar 2026 | 2 articles | Viewed by 3768 | Submission Open
Keywords: colorectal surgery; laparoscopy; abdominal wall surgery; hernia; diastasis recti; surgical oncology; rectal tumor; colon tumor; colorectal neoplasia
(This special issue belongs to the Section General Surgery)
Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition submission deadline 31 Mar 2026 | 2 articles | Viewed by 1291 | Submission Open
Keywords: perioperative care; enhanced recovery after surgery; prehabilitation; minimally invasive surgery; patient-related outcome measures; colorectal surgery; general surgery; thoracic surgery; vascular surgery; optimal functional recovery
(This special issue belongs to the Section General Surgery)
Recent Clinical Perspective in Kidney Transplantation
edited by Nikolina Bašić-Jukić
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1175 | Submission Open
Keywords: kidney transplantation; outcomes; desensitization; xenotransplantation; transplant nephropathology; multiorgan transplantations; post-transplant complications; inequities in transplantation
(This special issue belongs to the Section Nephrology & Urology)
Acute Trauma and Trauma Care in Orthopedics: 2nd Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 1019 | Submission Open
Keywords: orthopedics; trauma; injury; musculoskeletal; surgery; knee; osteoarthritis; spinal deformity; fracture; joint replacement; hip fractur; fragility fracture; minimally invasive surgery; post-traumatic care and rehabilitation; pain management; emergency assessment
(This special issue belongs to the Section Orthopedics)
Artificial Intelligence in Women’s Health and Medicine: Improving Clinical Practice, Diagnosis, Treatment Management and Patient Experiences
edited by and Nasibeh Zanjirani Farahani
submission deadline 31 Mar 2026 | 1 articles | Viewed by 979 | Submission Open
Keywords: women’ s health; artificial intelligence; machine learning; personalized medicine; reproductive health; health equity; social determinants of health; mental health; cancer; cardiovascular disease
(This special issue belongs to the Section Epidemiology & Public Health)
Paradigm Changes in Cardiac Surgery and Interventional Cardiology
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 799 | Submission Open
Keywords: cardiac surgery; trans-catheter interventions; ischaemic heart disease; structural heart disease; electrophysiological interventions; state-of-the-art techniques; golden standards; therapeutic guidelines
(This special issue belongs to the Section Cardiology)
JSOPB 2025–2026 Congress Special Issue–Update on Organ Preservation and Transplantation submission deadline 31 Mar 2026 | 1 articles | Viewed by 793 | Submission Open
Keywords: organ preservation; transplantation; pharmacology; engineering; stem cell therapy
(This special issue belongs to the Section General Surgery)
Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition
edited by and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 619 | Submission Open
Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms
(This special issue belongs to the Section Cardiology)
New Insights into Clinical Application of Embolization Techniques
edited by and Yan Epelboym
submission deadline 31 Mar 2026 | 1 articles | Viewed by 608 | Submission Open
Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy
(This special issue belongs to the Section Vascular Medicine)
Advancements in Lumbar Spine Surgery: Modern Strategies and Techniques
edited by Christian von der Brelie and Frank Beyer
submission deadline 31 Mar 2026 | 1 articles | Viewed by 247 | Submission Open
Keywords: lumbar spine; spine surgery; new techniques; robotics; minimally-invasive; artificial intelligence (AI); navigation
(This special issue belongs to the Section Orthopedics)
Pregnancy and Delivery Complications: Bridging Research and Clinical Practice
edited by , Andrei Mihai Malutan and Răzvan Ciortea
submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: maternal– fetal medicine; obstetric complications; perinatal health; pelvic floor disorders; childbirth perineal trauma; risk stratification; patient-reported outcomes; patient-reported outcome measures
(This special issue belongs to the Section Obstetrics & Gynecology)
Latest Advances in Glaucoma, Cataracts, and Refractive Surgery
edited by , Felix Wagner and
submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open
Keywords: glaucoma; cataract surgery; refractive surgery; minimally invasive glaucoma surgery (MIGS); laser vision correc-tion (LVC); keratorefractive lenticule extraction (KLEx); lenticule implantation; multifocal IOLs; extended depth-of-focus (EDOF) lenses; ocular imaging; optical coherence tomography (OCT); artificial intelligence in ophthalmology; corneal biomechanics; surgical innovation
(This special issue belongs to the Section Ophthalmology)
Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications
edited by
submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open
Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation
(This special issue belongs to the Section Oncology)
Endodontic Diseases: Prevalence, Risk Factors, and Treatment Outcomes
edited by Iris Slutzky-Goldberg, Shlomo Matalon and
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: cone beam computed tomography (cbct); diagnostic tools; endodontic therapy; peri-radicular pathologies; regenerative endodontics; risk factors; systemic disease; treatment outcome; vital pulp therapy
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Laser Dentistry: Emerging Therapeutic Concepts
edited by and Risako Mikami
submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open
Keywords: laser dentistry; dental treatment guidelines; refractory endodontic infection; root canal therapy; minimally invasive endodontics; anatomy; cone-beam computed tomography
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Oral Biology: Advances of Translating Experimental Findings into Clinical Dentistry and Oral Medicine
edited by
submission deadline 31 Mar 2026 | Viewed by 84 | Submission Open
Keywords: oral surgery; biomaterials; tissue engineering; regenerative medicine; dentistry dentin graft; growth factors; ad-vances orthodontics; skeletal anchorage with miniscrews; TADS; MADS; MARPE; aligner
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Current Emerging Treatment Options in Atrial Fibrillation
edited by Hoang Nhat Pham and Amitoj Singh
submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open
Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants
(This special issue belongs to the Section Cardiology)
Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities
edited by and Flavio Giuseppe Biccirè
submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open
Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy
(This special issue belongs to the Section Cardiology)
Current Challenges and Updates in Therapeutic Advancements of Prostatectomy submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Cardiovascular Radiology
edited by Amalia Lupi and Riccardo Cau
submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open
Keywords: CMR; tissue characterization; 4Dflow; CCTA; photon counting CT; plaque characterization
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Acute Care Surgery: The Evolution of a Modern Specialty
edited by Mayur Narayan
submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open
Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making
(This special issue belongs to the Section Emergency Medicine)
Glaucoma: Diagnosis and Management Insights
edited by and Eythimios Karmiris
submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open
Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management
(This special issue belongs to the Section Ophthalmology)
Geriatric Diseases: Management and Epidemiology
edited by
submission deadline 5 Apr 2026 | 9 articles | Viewed by 18152 | Submission Open
Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults
(This special issue belongs to the Section Geriatric Medicine)
Clinical Advances in Inflammatory Bowel Disease: 2nd Edition
edited by
submission deadline 5 Apr 2026 | 1 articles | Viewed by 621 | Submission Open
Keywords: inflammatory bowel diseases; IBD; Crohn’ s disease; ulcerative colitis; biomarkers; biologics; anti-JAKs; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity
edited by
submission deadline 5 Apr 2026 | Viewed by 107 | Submission Open
Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions
(This special issue belongs to the Section Respiratory Medicine)
Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition submission deadline 10 Apr 2026 | 7 articles | Viewed by 9099 | Submission Open
Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices
(This special issue belongs to the Section Clinical Neurology)
Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions
edited by Funda Göker, and
submission deadline 10 Apr 2026 | 2 articles | Viewed by 3734 | Submission Open
Keywords: oral and maxillofacial reconstructive surgery; MRONJ management; temporomandibular joint disorders; sental implants; zygomatic implants; guided surgery; alveolar bone regeneration; maxillofacial deformities; bone regeneration; head and neck cancer
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
COVID-19 and Endocrine Complications
edited by
submission deadline 10 Apr 2026 | 2 articles | Viewed by 1544 | Submission Open
Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Management of Patients with Heart Failure: 3rd Edition
edited by
submission deadline 10 Apr 2026 | 1 articles | Viewed by 562 | Submission Open
Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
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