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Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 10 October 2025 | Viewed by 393

Special Issue Editors


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Guest Editor
1. Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy
2. Dental and Maxillo-Facial Surgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy
Interests: oral and maxillofacial surgery; MRONJ management; orthognathic surgery; temporomandibular joint disorders; reconstructive surgery; bone regeneration; head and neck cancer; dental implants;zygomatic implants; guided surgery; biomaterials; tissue engineering; CAD/CAM methods; virtual surgical planning

E-Mail Website
Guest Editor
1. Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy
2. Dental and Maxillo-Facial Surgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy
Interests: oral surgery; MRONJ management; temporomandibular joint disorders; reconstructive surgery; bone regeneration; dental implants; zygomatic implants; guided surgery; biomaterials; tissue engineering; CAD/CAM methods; virtual surgical planning
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy
2. Dental and Maxillo-Facial Surgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy
Interests: oral and maxillofacial surgery; MRONJ management; temporomandibular joint disorders; bone regeneration; head and neck cancer; dental implants; zygomatic implants; guided surgery; biomaterials; tissue engineering; CAD/CAM methods; virtual surgical planning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a new Special Issue entitled “Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions”.

Oral and maxillofacial surgery is one the most challenging disciplines in the field of medicine due to the complex anatomy of the region and the wide array of conditions that may involve different types of tissues. Furthermore, in this region, both aesthetics and function are crucial factors, and achieving successful treatment results mostly depends on a precise diagnosis and an appropriate personalized approach.

This Special Issue aims to publish articles concerning the novel methods and protocols employed in the management of dentoalveolar and maxillofacial disorders, head and neck diseases, facial trauma, TMJ disorders, medication related osteonecrosis, and oral cancer.

In this Special Issue, all kinds of original research articles, systematic reviews and reviews are welcome. Research areas may include oral and maxillofacial surgery; MRONJ management; orthognathic surgery; temporomandibular joint disorders; maxillofacial deformities; maxillofacial trauma; dental implants; bone graft; maxillofacial reconstruction surgery; head and neck cancer; and oral and maxillofacial reconstruction and rehabilitation.

We look forward to receiving your contributions.

Dr. Funda Göker
Dr. Gianluca M. Tartaglia
Prof. Dr. Massimo Del Fabbro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral and maxillofacial reconstructive surgery
  • MRONJ management
  • temporomandibular joint disorders
  • sental implants
  • zygomatic implants
  • guided surgery
  • alveolar bone regeneration
  • maxillofacial deformities
  • bone regeneration
  • head and neck cancer

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Published Papers (1 paper)

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17 pages, 1072 KiB  
Systematic Review
Mesenchymal Stem Cells in Oral and Maxillofacial Surgery: A Systematic Review of Clinical Applications and Regenerative Outcomes
by Gianna Dipalma, Grazia Marinelli, Irene Palumbo, Mariafrancesca Guglielmo, Lilla Riccaldo, Roberta Morolla, Francesco Inchingolo, Andrea Palermo, Alessio Danilo Inchingolo and Angelo Michele Inchingolo
J. Clin. Med. 2025, 14(11), 3623; https://doi.org/10.3390/jcm14113623 - 22 May 2025
Abstract
Aim: This systematic review aims to evaluate the use of mesenchymal stem cells, particularly those derived from bone marrow, adipose tissue, and dental pulp in maxillofacial and oral surgery, focusing on their regenerative potential, clinical applications, and integration with biomaterials. Introduction: [...] Read more.
Aim: This systematic review aims to evaluate the use of mesenchymal stem cells, particularly those derived from bone marrow, adipose tissue, and dental pulp in maxillofacial and oral surgery, focusing on their regenerative potential, clinical applications, and integration with biomaterials. Introduction: Mesenchymal stem cells are multipotent stem cells known for their immunomodulatory and regenerative abilities. Their low immunogenicity and differentiation capacity make them ideal for treating craniofacial defects and enhancing soft tissue repair. Materials and Methods: The review followed PRISMA guidelines and was registered in PROSPERO. The literature was searched across PubMed, Scopus, and Web of Science from 2009 to 2024. Twelve studies met the inclusion criteria and were analyzed for clinical efficacy and methodological quality. Results: Clinical trials demonstrated the safety and regenerative benefits of mesenchymal stem cell in bone and soft tissue reconstruction. Adipose-derived stem cell and dental pulp stem cell showed favorable outcomes in angiogenesis and healing, while bone marrow’s cell proved effective in bone regeneration, particularly when combined with scaffolds. Discussion and Conclusions: Although results are promising, limitations remain in consistency and long-term outcomes. Optimizing scaffold integration, preservation methods, and delivery techniques is crucial. Mesenchymal stem cell-based therapies represent a powerful, minimally invasive alternative to traditional grafting in oral and maxillofacial surgery. Full article
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