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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1300 | Submission Open
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
Recent Progress and Future Directions in Orthopedic Oncology
edited by and Carmine Zoccali
submission deadline 31 Dec 2025 | 1 articles | Viewed by 909 | Submission Open
Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology
(This special issue belongs to the Section Orthopedics)
Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 898 | Submission Open
Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery
(This special issue belongs to the Section Respiratory Medicine)
Innovations in Psychosis and Schizophrenia: New Findings and Implications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 774 | Submission Open
Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions
(This special issue belongs to the Section Mental Health)
Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions
edited by Pietro C. Dattolo and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 713 | Submission Open
Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction submission deadline 31 Dec 2025 | 1 articles | Viewed by 482 | Submission Open
Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations
(This special issue belongs to the Section Ophthalmology)
Orthopedic Oncology Updates and Controversial Issues
edited by Yehuda Kollender and Ron Batash
submission deadline 31 Dec 2025 | Viewed by 344 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy
(This special issue belongs to the Section Orthopedics)
Paradigms, Advances and Future Directions in Oral Medicine
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 337 | Submission Open
Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Gene Therapy for Retinal Diseases
edited by Tahreem Aman Mir
submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open
Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Diagnostic Radiology
edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen
submission deadline 31 Dec 2025 | Viewed by 192 | Submission Open
Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications
(This special issue belongs to the Section Nuclear Medicine & Radiology)
The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open
Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine
(This special issue belongs to the Section Cardiovascular Medicine)
Progress in the Multimodal Treatment of Pancreatic Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 149 | Submission Open
Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management
edited by Adam Gwozdz
submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open
Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery
(This special issue belongs to the Section Vascular Medicine)
Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment
edited by
submission deadline 5 Jan 2026 | 1 articles | Viewed by 2714 | Submission Open
Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted
(This special issue belongs to the Section Mental Health)
Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition
edited by
submission deadline 9 Jan 2026 | 3 articles | Viewed by 3182 | Submission Open
Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Pancreatobiliary Diseases
edited by
submission deadline 9 Jan 2026 | 1 articles | Viewed by 890 | Submission Open
Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention
edited by Anbukarasi Maran and Kevin Croce
submission deadline 9 Jan 2026 | Viewed by 136 | Submission Open
Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology  
(This special issue belongs to the Section Cardiovascular Medicine)
Heart Disease and Chronic Inflammatory Conditions: New Insights
edited by Ofer Kobo and Gilad Margolis
submission deadline 10 Jan 2026 | 4 articles | Viewed by 13188 | Submission Open
Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease
(This special issue belongs to the Section Cardiology)
Clinical Guidelines in Critical Care Medicine
edited by , and Daniela Bandic-Pavlovic
submission deadline 10 Jan 2026 | 3 articles | Viewed by 6329 | Submission Open
Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging
(This special issue belongs to the Section Intensive Care)
Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities submission deadline 10 Jan 2026 | 3 articles | Viewed by 4417 | Submission Open
Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
From Acute Injury to Personalized Prevention—Developing Modern Strategies submission deadline 10 Jan 2026 | 2 articles | Viewed by 2077 | Submission Open
Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention
(This special issue belongs to the Section Orthopedics)
Advancements in Spinal Oncology: The Current Landscape
edited by Aladine Elsamadicy and
submission deadline 10 Jan 2026 | 1 articles | Viewed by 1859 | Submission Open
Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors
(This special issue belongs to the Section Clinical Neurology)
Pelvic Organ Prolapse: Clinical Advances and Challenges submission deadline 10 Jan 2026 | 1 articles | Viewed by 353 | Submission Open
Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment
(This special issue belongs to the Section Obstetrics & Gynecology)
Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders submission deadline 10 Jan 2026 | Viewed by 162 | Submission Open
Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Vascular and Endovascular Surgery: Second Edition
edited by and Afshin Assadian
submission deadline 11 Jan 2026 | 4 articles | Viewed by 3462 | Submission Open
Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders submission deadline 15 Jan 2026 | 10 articles | Viewed by 28277 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Physical Therapy in Neurorehabilitation submission deadline 15 Jan 2026 | 8 articles | Viewed by 21488 | Submission Open
Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders
(This special issue belongs to the Section Clinical Neurology)
Innovative Systemic Treatments for Atopic Dermatitis
edited by
submission deadline 15 Jan 2026 | 5 articles | Viewed by 16775 | Submission Open
Keywords: atopic dermatitis; atopic eczema; JAK inhibitors; anti-IL-4; anti-IL-13; dupilumab; tralokinumab; lebrikizumab; abrocitinib; upadacitinib; baricitinib
(This special issue belongs to the Section Dermatology)
Clinical Application of Biomarkers in Cancers
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 14396 | Submission Open
Keywords: cancer biomarkers; early detection; personalized therapy; biomarker validation; advanced technologies; clinical implementation
(This special issue belongs to the Section Clinical Laboratory Medicine)
Current Trends and Prospects of Critical Emergency Medicine
edited by Quincy K. Tran
submission deadline 15 Jan 2026 | 8 articles | Viewed by 8668 | Submission Open
Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes
(This special issue belongs to the Section Emergency Medicine)
Advances in Pulmonary Disease Management and Innovation in Treatment submission deadline 15 Jan 2026 | 5 articles | Viewed by 7445 | Submission Open
Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Assessment Measures and Theoretical Models of Caregivers' Sensitivity and Contingency: 2nd Edition
edited by
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4855 | Submission Open
Keywords: clinical caregiving; sensitivity assessment; contingency modeling; caregiver– patient interactions; mental health outcomes; novel assessment measures; therapeutic responsiveness; caregiver interventions; clinical well-being; care recipient support
(This special issue belongs to the Section Intensive Care)
Pulmonary Embolism—Current and Novel Approaches
edited by Roy Beigel and Shlomi Matetzky
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4839 | Submission Open
Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Minimally Invasive Urologic Surgery
edited by , Fabio Crocerossa and
submission deadline 15 Jan 2026 | 3 articles | Viewed by 4084 | Submission Open
Keywords: urology; uro-oncology; uro-gynecology; robotic surgery; laparoscopy; robot-assisted; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Safety in Spinal Surgery
edited by Simon B. Roberts and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 4037 | Submission Open
Keywords: spinal surgery; patients with spinal deformity; inherent risks; risk management; surgery safety
(This special issue belongs to the Section General Surgery)
Clinical Management and Treatment of Psoriasis
edited by
submission deadline 15 Jan 2026 | 2 articles | Viewed by 3677 | Submission Open
Keywords: psoriasis; biological drugs; personalized medicine; comorbidities; real-world evidence
(This special issue belongs to the Section Dermatology)
Clinical Advances in the Diagnosis and Treatment of Cardiac Arrhythmias
edited by Fabrizio Guarracini and
submission deadline 15 Jan 2026 | 3 articles | Viewed by 3214 | Submission Open
Keywords: cardiac arrhythmias; antiarrhythmic agents; pacemakers; cardiac resynchronization; catheter ablation; electrophysiology
(This special issue belongs to the Section Cardiology)
Up-to-Date Research in Liver Transplantation
edited by
submission deadline 15 Jan 2026 | 1 articles | Viewed by 2445 | Submission Open
Keywords: liver transplantation; acute or chronic liver diseases; hepatitis C virus infection; hepatocellular carcinoma (HCC); cirrhosis; intrahepatic (ICCA); perihilar (PCCA) cholangiocarcinoma; unresectable liver metastases; acute or chronic liver failure (ACLF); acute alcoholic hepatitis (AAH)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders submission deadline 15 Jan 2026 | 3 articles | Viewed by 2081 | Submission Open
Keywords: diagnosis; management; treatment; kidney disorders; chronic kidney disease; biomarkers; genetic testing; kidney; children; newborn
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis and Management of Aortic Diseases: Drafting from Theoretical Aspects to Clinical Practice—2nd Edition submission deadline 15 Jan 2026 | 2 articles | Viewed by 1913 | Submission Open
Keywords: aortic disease; aortic aneurysm; aortic dissection; aortic surgery; diagnosis and management
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Jan 2026 | 2 articles | Viewed by 1810 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Intracranial Hemorrhage: Advances in Diagnosis, Management and Treatment
edited by Hitoshi Fukuda
submission deadline 15 Jan 2026 | 1 articles | Viewed by 1011 | Submission Open
Keywords: intracerebral hemorrhage; subarachnoid hemorrhage; traumatic hemorrhage; prehospital care; less invasive surgery; vascular malformation; antihypertensive drug; intracranial pressure elevation; decompressive craniectomy; neurocritical care; nursing care; rehabilitation
(This special issue belongs to the Section Clinical Neurology)
Pediatric Urology: How to Adapt Current Knowledge to the New Era
edited by Simona Gerocarni Nappo and
submission deadline 15 Jan 2026 | 1 articles | Viewed by 805 | Submission Open
Keywords: pediatric urology; telemedicine; telesurgery; artificial intelligence; 3D-models; congenital urinary diseases; pediatric oncology
(This special issue belongs to the Section Clinical Pediatrics)
Advances in Oculoplastic Surgery and Ocular Surface Diseases
edited by Michael T. Yen, Francesco Quaranta Leoni and
submission deadline 15 Jan 2026 | Viewed by 221 | Submission Open
Keywords: ocular surface disease; corneal neurotization; neurotrophic keratopathy; eyelid malposition; facial nerve palsy; thyroid eye disease; oculoplastic surgery; hemocomponents; dry anophthalmic socket; corneal pathology; ocular surface reconstruction; exposure keratopathy
(This special issue belongs to the Section Ophthalmology)
Chronic Kidney Disease: Current Challenges and Adverse Outcomes
edited by and Flaviu Bob
submission deadline 15 Jan 2026 | Viewed by 164 | Submission Open
Keywords: chronic kidney disease; CKD progression; hemodialysis; cardiovascular complications; vascular calcification; lifestyle; nutrition; bone and mineral disorders; CKD-associated osteoporosis; mortality
(This special issue belongs to the Section Nephrology & Urology)
Advances in Minimally Invasive Cardiothoracic Surgery: Current Techniques and Future Innovations submission deadline 15 Jan 2026 | Viewed by 150 | Submission Open
Keywords: cardiothoracic surgery; lung cancer; cardiac imaging; minimally invasive surgery; thoracic oncology
(This special issue belongs to the Section Cardiovascular Medicine)
Pulmonary Critical Care: Diagnosis and Treatment of Respiratory System Diseases
edited by Yaron Bar-Lavie
submission deadline 15 Jan 2026 | Viewed by 149 | Submission Open
Keywords: acute respiratory distress syndrome (ARDS); mechanical ventilation; chronic obstructive pulmonary disease (COPD); sepsis-induced lung injury; pulmonary fibrosis; bronchoscopy in critical care
(This special issue belongs to the Section Intensive Care)
Insights into Acute Pancreatitis: Pathogenesis, Diagnosis, and Management
edited by Gil Nissim Bachar and Ram Dickman
submission deadline 15 Jan 2026 | Viewed by 140 | Submission Open
Keywords: acute pancreatitis; pancreatic inflammation; necrotizing pancreatitis; clinical outcomes; ultrasound examination
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Epilepsy Researches submission deadline 15 Jan 2026 | Viewed by 138 | Submission Open
Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers
(This special issue belongs to the Section Clinical Neurology)
Artificial Intelligence in Gastrointestinal Disorders: Current Updates from Theory to Clinical Practice submission deadline 15 Jan 2026 | Viewed by 137 | Submission Open
Keywords: artificial intelligence; gastroenterology; medical imaging; endoscopy; prognostic modeling; ethical considerations
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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