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Chronic Kidney Disease: Current Challenges and Adverse Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 343

Special Issue Editors


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Guest Editor
Department of Nephrology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
Interests: chronic kidney disease; CKD progression; hemodialysis; cardiovascular complications; vascular calcification; lifestyle; nutrition; bone and mineral disorders; mortality

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Guest Editor
1. Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine “Victor Babes”, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
2. Discipline of Nephrology, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
Interests: chronic kidney disease; hemodialysis; diabetic kidney disease; renal; glomerulonephritis

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) often remains asymptomatic until advanced stages, making early diagnosis difficult. Improved screening and biomarkers are essential to identify CKD earlier and initiate timely interventions. Controlling progression involves comprehensive management, including hypertension, diabetes, and lifestyle factors. Understanding individual patient risk profiles can tailor treatments to slow kidney function decline. CKD leads to complications like cardiovascular disease, anemia, and bone disorders and effective management strategies are needed to reduce adverse outcomes and to improve quality of life. By mobilizing interdisciplinary efforts, we aim to develop improved diagnostics, therapies, and management strategies to reduce CKD adverse outcomes. In this Special Issue, we encourage submissions from clinicians, health experts, and researchers worldwide to share insights and novel approaches to epidemiology, diagnosis, and treatment advances in chronic kidney disease.

Dr. Diana Tania Luminița Moldovan
Prof. Dr. Flaviu Bob
Guest Editors

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Keywords

  • chronic kidney disease
  • CKD progression
  • hemodialysis
  • cardiovascular complications
  • vascular calcification
  • lifestyle
  • nutrition
  • bone and mineral disorders
  • CKD-associated osteoporosis
  • mortality

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Published Papers (1 paper)

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Research

12 pages, 384 KB  
Article
Dental Caries and Erosion in Children with Nephrotic Syndrome on Long-Term Liquid Medications—A Cross-Sectional Observational Study
by Adel N. Radwan, Osama M. Felemban, Jameela A. Kari, Sherif M. El Desoky, Khlood Baghlaf and Heba Mohamed Elkhodhary
J. Clin. Med. 2025, 14(24), 8669; https://doi.org/10.3390/jcm14248669 - 7 Dec 2025
Viewed by 150
Abstract
Objectives: This study aimed to evaluate the experience and consequences of dental caries and erosion in children aged 1–14 years on long-term liquid medications compared to those not on these medications. Methods: A cross-sectional observational study was conducted using a WHO-adapted [...] Read more.
Objectives: This study aimed to evaluate the experience and consequences of dental caries and erosion in children aged 1–14 years on long-term liquid medications compared to those not on these medications. Methods: A cross-sectional observational study was conducted using a WHO-adapted questionnaire, medical surveys, and oral examinations. Participants included children with nephrotic syndrome in two groups: those on long-term liquid medications for at least three months (study group) and those not taking liquid medications (control group). The Decayed, Missing, and Filled Surfaces index (dmfs/DMFS) assessed caries, while the Pulpal Involvement, Ulceration, Fistula, and Abscess index (PUFA/pufa) measured caries consequences. The Basic Erosive Wear Examination index (BEWE) assessed erosion. Results: A total of 64 participants were included, with 33 in the study group and 31 in the control group. The study group had a significantly higher mean dmfs/DMFS of 16.9 ± 12.6 versus 5.2 ± 4.0 in the control group (p < 0.001). The PUFA/pufa index was also higher in the study group (0.8) compared to the control group (0.1) (p = 0.009). Erosion showed a non-significant increase with a BEWE score of 0.2 vs. 0.03 in the control group (p = 0.053). Conclusions: Long-term liquid medication use significantly affects dental caries in children after three months. Full article
(This article belongs to the Special Issue Chronic Kidney Disease: Current Challenges and Adverse Outcomes)
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