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Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 610

Special Issue Editors

Dr. Salvatore Troisi

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Guest Editor
Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Scuola Medica Salernitana-U.O.C. di Oftalmologia, 84131 Salerno, SA, Italy
Interests: ophthalmology; ocular surface pathologies; keratitis; conjunctivitis; dry eye; glaucoma; keratoconus; cornea; cataract surgery; refractive surgery; corneal cross-linking
Special Issues, Collections and Topics in MDPI journals
Dr. Livio Vitiello

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Guest Editor
Eye Unit, “Luigi Curto” Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy
Interests: ophthalmology; ocular ultrasound; medical retina; retinal diseases; glaucoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ocular surface disease (OSD) encompasses a wide range of conditions, including dry eye disease, blepharitis, and ocular allergies, that result in progressive histopathologic and clinical alterations to the ocular surface, along with tear film instability, symptoms of discomfort, and visual abnormalities which significantly impact patients' quality of life.

This Special Issue aims to explore recent breakthroughs in the understanding, diagnosis, and treatment of OSD. It will feature original research and reviews on innovative diagnostic tools such as tear biomarkers, advanced imaging techniques, and artificial intelligence in OSD assessment. Moreover, the issue will highlight novel therapeutic strategies, including biologics, regenerative medicine approaches, and next-generation lubricants. A strong emphasis will be placed on integrating these advancements into patient-centered care, addressing real-world challenges such as accessibility, adherence, and personalized treatment regimens. Contributions will also examine the psychosocial impact of OSD, providing a holistic perspective on managing this multifaceted condition. By bridging clinical research and practical application, this Special Issue aims to enhance the understanding of OSD and promote strategies that improve patient outcomes and quality of care.

You may choose our Joint Special Issue in JCTO.

Dr. Salvatore Troisi
Dr. Livio Vitiello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dry eye disease
  • ocular surface
  • corneal disease
  • conjunctival disease
  • ocular biomarkers
  • patient-centered care
  • advanced diagnostics
  • regenerative medicine
  • artificial intelligence
  • therapeutic innovations

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Published Papers (1 paper)

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Research

11 pages, 389 KB  
Article
Impact of Lid Wipes and Tear Substitutes on Symptoms and Signs of Ocular Surface Disease After Cataract Surgery—A Real-Life Study
by Giulia Coco, Laura Antonia Meliante, Francesca Di Stefano, Livio Vitiello and Giuseppe Giannaccare
J. Clin. Med. 2025, 14(22), 8140; https://doi.org/10.3390/jcm14228140 - 17 Nov 2025
Viewed by 305
Abstract
Objective: To evaluate the efficacy of lid wipes and tear substitutes, in addition to standard postoperative treatment, in alleviating signs and symptoms of ocular surface disease (OSD) following cataract surgery. Methods: Retrospective study on patients who underwent cataract surgery and received either standard [...] Read more.
Objective: To evaluate the efficacy of lid wipes and tear substitutes, in addition to standard postoperative treatment, in alleviating signs and symptoms of ocular surface disease (OSD) following cataract surgery. Methods: Retrospective study on patients who underwent cataract surgery and received either standard postoperative treatment (topical antibiotics, corticosteroids, and nonsteroidal anti-inflammatory drugs) or the same regimen supplemented with lid wipes and tear substitutes. Preoperatively and one month postoperatively, symptoms were evaluated using the 5-item Dry Eye Questionnaire (DEQ-5) and the Ocular Surface Disease Index (OSDI), while noninvasive keratograph break-up time (NIKBUT), tear meniscus height (TMH), conjunctival hyperemia, and infrared meibography were measured by the Oculus Keratograph. Results: A total of 63 patients (mean age 75.1 ± 6.3 years) were analyzed. Patients receiving standard treatment showed no significant changes in OSDI (+2 ± 32.7; p = 0.859) or DEQ-5 scores (+1.7 ± 5.4; p = 0.204). Conversely, those receiving the adjunct of lid wipes and tear substitutes demonstrated significant improvement in OSDI scores (−19.4 ± 15.9; p < 0.0001), a trend toward improvement in DEQ-5 scores (−1.9 ± 5.5; p = 0.059), and a reduction in the meibography score of the inferior eyelid (−0.24 ± 0.60; p = 0.023). Intergroup comparisons showed significantly greater improvements in both OSDI and DEQ-5 scores in patients receiving treatment for the ocular surface. Multivariate regression analysis confirmed the association between the use of wipes and tear substitutes and improvements in OSDI (p = 0.010) and DEQ-5 scores (p = 0.015). No significant postoperative changes in objective OSD parameters were observed in either group. Conclusions: The addition of lid wipes and tear substitutes to the standard postoperative regimen significantly improved patient-reported symptoms of ocular discomfort after cataract surgery, while no significant changes were observed in objective signs of ocular surface disease. These findings support the routine use of lid wipes and tear substitutes as an effective strategy for managing postoperative ocular surface discomfort. Full article
(This article belongs to the Special Issue Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction)
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