Advancements in Spinal Oncology: The Current Landscape

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1113

Special Issue Editors


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Guest Editor
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
Interests: neurosurgery; spine outcomes; spine deformity; spinal oncology; spine surgery

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Guest Editor
Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center, North Shore University Hospital, Northwell Health, Manhasset, NY 11030, USA
Interests: spinal oncology; chordoma; predictive calculators and machine learning; perioperative optimization; adult spinal deformity; machine learning in spine surgery
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Special Issue Information

Dear Colleagues,

As the patient population ages, the number of patients presenting with a spinal oncological pathology has been increasing. While surgical consideration is a component of treatment, these pathologies require a multidisplinary approach. Therefore, there is a need for better understanding an evolving treatment paradigm as the landscape continues to change with advances in surgical techniques and adjunct therapies. In the present Special Issue for the Journal of Clinical Medicine, we aim to highlight current research focused on the management of spinal oncology, including both primary and metastatic pathologies. We welcome a broad approach for this Special Issue from, but not limited to, surgical considerations, patient optimization, imaging advances, and multidisciplinary treatment advances.

Dr. Aladine Elsamadicy
Prof. Dr. Daniel M. Sciubba
Guest Editors

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Keywords

  • spinal oncology
  • patient outcomes
  • primary bone tumor
  • spine metastases
  • intradural tumors

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Published Papers (1 paper)

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13 pages, 68362 KiB  
Technical Note
Indocyanine Green as a Marker for Tissue Ischemia in Spinal Tumor Resections and Extended Revisions: A Technical Note
by Max Ward, Daniel Schneider, Ethan D. L. Brown, Apratim Maity, Barnabas Obeng-Gyasi, Roee Ber, Aladine A. Elsamadicy, Daniel M. Sciubba, Denis Knobel and Sheng-Fu Larry Lo
J. Clin. Med. 2025, 14(3), 914; https://doi.org/10.3390/jcm14030914 - 30 Jan 2025
Viewed by 752
Abstract
Background/Objectives: The increasing complexity of spinal oncology procedures, particularly in en-bloc tumor resections, creates challenges in tissue perfusion assessment due to extended operative times and extensive surgical dissection. Real-time visualization of tissue perfusion can be achieved with ICG using commercially available handheld imaging [...] Read more.
Background/Objectives: The increasing complexity of spinal oncology procedures, particularly in en-bloc tumor resections, creates challenges in tissue perfusion assessment due to extended operative times and extensive surgical dissection. Real-time visualization of tissue perfusion can be achieved with ICG using commercially available handheld imaging systems, offering potential advantages in spinal oncology cases. This study assessed the utility of ICG in analyzing soft-tissue viability during complex spine procedures extending beyond 7.5 h, with a particular focus on oncologic resections. Methods: Three cases that required over 7.5 h of operative time were chosen for ICG utilization. These cases included an en-bloc malignant peripheral nerve sheath tumor resection, an en-bloc resection of a malignant epithelioid neoplasm, and a long-segment fusion revision for pseudoarthrosis. At the conclusion of the critical portion of the procedure, a handheld intraoperative fluorescence camera was utilized to visualize the tissue penetration of intravenous ICG. Results: Prior to injecting ICG, devascularized tissue was not clearly visible. Injecting ICG allowed clear separation of vascularized (fluorescing) and devascularized (non-fluorescing) tissues. One region of non-florescent tissue was later confirmed to be devascularized with MRI and experienced postoperative infection. Conclusions: As the complexity of spinal oncology procedures increases, ICG fluorescence imaging offers a novel method for real-time assessment of tissue perfusion. This technique may be particularly valuable in extensive tumor resections, post-radiation cases, and revision surgeries where tissue viability is at risk. Further investigation in the spinal oncology population could help establish whether early identification of poorly perfused tissues impacts wound healing outcomes. Full article
(This article belongs to the Special Issue Advancements in Spinal Oncology: The Current Landscape)
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