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JCM
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Recent Clinical Advances in Percutaneous Coronary Intervention
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Recent Clinical Advances in Percutaneous Coronary Intervention

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 499

Special Issue Editors

Prof. Dr. Lampson Fan

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Guest Editor
Cardiothoracic Directorate, Heart and Lung Center, New Cross Hospital, Royal Wolverhampton Trust, Wolverhampton WV10 0QP, UK
Interests: coronary artery disease; coronary artery intervention; atherosclerosis; left ventricular assist device; complex intervention; coronary physiology; microvascular disease; interventional cardiology
Dr. Luke Pickup

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Guest Editor
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
Interests: cardiovascular disease; coronary artery disease; interventional cardiology

Special Issue Information

Dear Colleagues,

There has been significant progress in the field of Percutanous Coronary Intervention (PCI) due to the development of new technologies and advances in research. Complex coronary artery diseases that were previously only treatable with coronary artery bypass grafting, including chronic total occlusion and left main stem disease, are now successfully treated with PCI, with comparable outcomes. Furthermore, advances in mechanical circulatory support, such as Impella, have further improved the safety and success rate of complex PCI. In this Special Issue, we invite authors to submit papers on recent clinical advances in PCI. 

Prof. Dr. Lampson Fan
Dr. Luke Pickup
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • complex PCI
  • calcium modification
  • left main stem
  • stent
  • coronary artery disease
  • atherectomy
  • mechanical circula-tory support device
  • Impella
  • DCB
  • intra-coronary imaging
  • IVUS
  • OCT

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

10 pages, 985 KiB  
Article
Safety of Ticagrelor Compared to Clopidogrel in the Contemporary Management Through Invasive or Non-Invasive Strategies of Elderly Patients Presenting with Acute Coronary Syndromes
by Anum Nazir, Smrthi Shetty Ujjar, Seemi Saba, Neil Ruparelia, Nicos Spyrou and Lampson Fan
J. Clin. Med. 2025, 14(16), 5629; https://doi.org/10.3390/jcm14165629 - 8 Aug 2025
Viewed by 400
Abstract
Background: ESC recommends ticagrelor over clopidogrel for the treatment of acute coronary syndrome (ACS) but the lack of evidence for elderly patients (≥75) and concerns over bleeding has led to significant variability in its use within the UK. Our aim is, therefore, to [...] Read more.
Background: ESC recommends ticagrelor over clopidogrel for the treatment of acute coronary syndrome (ACS) but the lack of evidence for elderly patients (≥75) and concerns over bleeding has led to significant variability in its use within the UK. Our aim is, therefore, to compare the safety of ticagrelor compared to clopidogrel in real-world elderly patients admitted with ACS and managed either medically or through percutaneous intervention. Methods: Unselected elderly patients (≥75) admitted to Royal Berkshire Hospital with ACS (2013–2015) were identified and followed for 1 year. The primary outcomes were bleeding events (TIMI criteria), all-cause mortality, cardiovascular mortality, ischemic stroke, angina, NSTEMI and STEMI. Results: A total of 288 patients with ACS were discharged with aspirin and either clopidogrel (137) or ticagrelor (151). In total, 152 of these patients underwent invasive angiography and revascularization. The baseline clinical characteristics and crusade bleeding score were similar between the groups receiving ticagrelor or clopidogrel. There were no significant differences in all-cause mortality (8.8% vs. 10.6%), cardiovascular mortality (2.9% vs. 2.0%), ischemic stroke (0.7% vs. 2.0%), angina (6.6% vs. 5.3%) or STEMI (2.2% vs. 1.3%). Patients on clopidogrel, however, had increased events of NSTEMI compared to ticagrelor (8.0% vs. 2.0%, OR 4.481, 95% CI 1.223–16.42) and overall MI (10.2% vs. 3.3%, p = 0.030). No difference was observed in either major (8.8 vs. 8.6%) or minor TIMI bleeding (18.2% vs. 20.5%) and after propensity score matching (minor bleeding p = 0.39, major bleeding p = 0.76). Conclusions: In this real-world analysis, ticagrelor did not increase major or fatal bleeding compared to clopidogrel in elderly patients. In view of the mortality benefit in the large trials, additional cardiovascular benefit of ticagrelor should not be withheld on the basis of age as a perceived risk factor for bleeding in ACS. Full article
(This article belongs to the Special Issue Recent Clinical Advances in Percutaneous Coronary Intervention)
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